FZD1 (fzd1_human)
FAMILY
Class F (Frizzled) Protein receptors Frizzled FZD1
GENE
FZD1
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Frizzled-1, Fz-1, hFz1, FzE1
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
E
|
E
|
E
|
A
|
P
|
K
|
K
|
S
|
10 |
R
|
A
|
A
|
G
|
G
|
G
|
A
|
S
|
W
|
E
|
20 |
L
|
C
|
A
|
G
|
A
|
L
|
S
|
A
|
R
|
L
|
30 |
A
|
E
|
E
|
G
|
S
|
G
|
D
|
A
|
G
|
G
|
40 |
R
|
R
|
R
|
P
|
P
|
V
|
D
|
P
|
R
|
R
|
50 |
L
|
A
|
R
|
Q
|
L
|
L
|
L
|
L
|
L
|
W
|
60 |
L
|
L
|
E
|
A
|
P
|
L
|
L
|
L
|
G
|
V
|
70 |
R
|
A
|
Q
|
A
|
A
|
G
|
Q
|
G
|
P
|
G
|
80 |
Q
|
G
|
P
|
G
|
P
|
G
|
Q
|
Q
|
P
|
P
|
90 |
P
|
P
|
P
|
Q
|
Q
|
Q
|
Q
|
S
|
G
|
Q
|
100 |
Q
|
Y
|
N
|
G
|
E
|
R
|
G
|
I
|
S
|
V
|
110 |
P
|
D
|
H
|
G
|
Y
|
C
|
Q
|
P
|
I
|
S
|
120 |
I
|
P
|
L
|
C
|
T
|
D
|
I
|
A
|
Y
|
N
|
130 |
Q
|
T
|
I
|
M
|
P
|
N
|
L
|
L
|
G
|
H
|
140 |
T
|
N
|
Q
|
E
|
D
|
A
|
G
|
L
|
E
|
V
|
150 |
H
|
Q
|
F
|
Y
|
P
|
L
|
V
|
K
|
V
|
Q
|
160 |
C
|
S
|
A
|
E
|
L
|
K
|
F
|
F
|
L
|
C
|
170 |
S
|
M
|
Y
|
A
|
P
|
V
|
C
|
T
|
V
|
L
|
180 |
E
|
Q
|
A
|
L
|
P
|
P
|
C
|
R
|
S
|
L
|
190 |
C
|
E
|
R
|
A
|
R
|
Q
|
G
|
C
|
E
|
A
|
200 |
L
|
M
|
N
|
K
|
F
|
G
|
F
|
Q
|
W
|
P
|
210 |
D
|
T
|
L
|
K
|
C
|
E
|
K
|
F
|
P
|
V
|
220 |
H
|
G
|
A
|
G
|
E
|
L
|
C
|
V
|
G
|
Q
|
230 |
N
|
T
|
S
|
D
|
K
|
G
|
T
|
P
|
T
|
P
|
240 |
S
|
L
|
L
|
P
|
E
|
F
|
W
|
T
|
S
|
N
|
250 |
P
|
Q
|
H
|
G
|
G
|
G
|
G
|
H
|
R
|
G
|
260 |
G
|
F
|
P
|
G
|
G
|
A
|
G
|
A
|
S
|
E
|
270 |
R
|
G
|
K
|
F
|
S
|
C
|
P
|
R
|
A
|
L
|
280 |
K
|
V
|
P
|
S
|
Y
|
L
|
N
|
Y
|
H
|
F
|
290 |
L
|
G
|
E
|
K
|
D
|
C
|
G
|
A
|
P
|
C
|
300 |
E
|
P
|
T
|
K
|
V
|
Y
|
G
|
L
|
M
|
Y
|
310 |
TM1 | |||||||||
F
|
G
|
P
|
E
|
E
|
L
|
R
|
F
|
S
|
R
|
320 |
T
|
W
|
I
|
G
|
I
|
W
|
S
|
V
|
L
|
C
|
330 |
C
|
A
|
S
|
T
|
L
|
F
|
T
|
V
|
L
|
T
|
340 |
ICL1 | |||||||||
Y
|
L
|
V
|
D
|
M
|
R
|
R
|
F
|
S
|
Y
|
350 |
TM2 | |||||||||
P
|
E
|
R
|
P
|
I
|
I
|
F
|
L
|
S
|
G
|
360 |
C
|
Y
|
T
|
A
|
V
|
A
|
V
|
A
|
Y
|
I
|
370 |
ECL1 | |||||||||
A
|
G
|
F
|
L
|
L
|
E
|
D
|
R
|
V
|
V
|
380 |
C
|
N
|
D
|
K
|
F
|
A
|
E
|
D
|
G
|
A
|
390 |
R
|
T
|
V
|
A
|
Q
|
G
|
T
|
K
|
K
|
E
|
400 |
TM3 | |||||||||
G
|
C
|
T
|
I
|
L
|
F
|
M
|
M
|
L
|
Y
|
410 |
F
|
F
|
S
|
M
|
A
|
S
|
S
|
I
|
W
|
W
|
420 |
V
|
I
|
L
|
S
|
L
|
T
|
W
|
F
|
L
|
A
|
430 |
ICL2 | TM4 | ||||||||
A
|
G
|
M
|
K
|
W
|
G
|
H
|
E
|
A
|
I
|
440 |
E
|
A
|
N
|
S
|
Q
|
Y
|
F
|
H
|
L
|
A
|
450 |
A
|
W
|
A
|
V
|
P
|
A
|
I
|
K
|
T
|
I
|
460 |
ECL2 | |||||||||
T
|
I
|
L
|
A
|
L
|
G
|
Q
|
V
|
D
|
G
|
470 |
D
|
V
|
L
|
S
|
G
|
V
|
C
|
F
|
V
|
G
|
480 |
TM5 | |||||||||
L
|
N
|
N
|
V
|
D
|
A
|
L
|
R
|
G
|
F
|
490 |
V
|
L
|
A
|
P
|
L
|
F
|
V
|
Y
|
L
|
F
|
500 |
I
|
G
|
T
|
S
|
F
|
L
|
L
|
A
|
G
|
F
|
510 |
V
|
S
|
L
|
F
|
R
|
I
|
R
|
T
|
I
|
M
|
520 |
ICL3 | TM6 | ||||||||
K
|
H
|
D
|
G
|
T
|
K
|
T
|
E
|
K
|
L
|
530 |
E
|
K
|
L
|
M
|
V
|
R
|
I
|
G
|
V
|
F
|
540 |
S
|
V
|
L
|
Y
|
T
|
V
|
P
|
A
|
T
|
I
|
550 |
V
|
I
|
A
|
C
|
Y
|
F
|
Y
|
E
|
Q
|
A
|
560 |
F
|
R
|
D
|
Q
|
W
|
E
|
R
|
S
|
W
|
V
|
570 |
A
|
Q
|
S
|
C
|
K
|
S
|
Y
|
A
|
I
|
P
|
580 |
ECL3 | |||||||||
C
|
P
|
H
|
L
|
Q
|
A
|
G
|
G
|
G
|
A
|
590 |
P
|
P
|
H
|
P
|
P
|
M
|
S
|
P
|
D
|
F
|
600 |
TM7 | |||||||||
T
|
V
|
F
|
M
|
I
|
K
|
Y
|
L
|
M
|
T
|
610 |
L
|
I
|
V
|
G
|
I
|
T
|
S
|
G
|
F
|
W
|
620 |
H8 | |||||||||
I
|
W
|
S
|
G
|
K
|
T
|
L
|
N
|
S
|
W
|
630 |
R
|
K
|
F
|
Y
|
T
|
R
|
L
|
T
|
N
|
S
|
640 |
C-term | ||||||
K
|
Q
|
G
|
E
|
T
|
T
|
V
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
Wnt-7b, Wnt-5a, Wnt-1, Wnt-2, Wnt-3a
STRUCTURE MODELS
STRUCTURES
No structures available