CCRL2 (ccrl2_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors CCRL2
GENE
CCRL2 (CCR11, CCR6, CKRX, CRAM, HCR)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C-C chemokine receptor-like 2, Chemokine receptor CCR11, Chemokine receptor X, Putative MCP-1 chemokine receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
N
|
Y
|
T
|
L
|
A
|
P
|
E
|
D
|
10 |
E
|
Y
|
D
|
V
|
L
|
I
|
E
|
G
|
E
|
L
|
20 |
E
|
S
|
D
|
E
|
A
|
E
|
Q
|
C
|
D
|
K
|
30 |
TM1 | |||||||||
Y
|
D
|
A
|
Q
|
A
|
L
|
S
|
A
|
Q
|
L
|
40 |
V
|
P
|
S
|
L
|
C
|
S
|
A
|
V
|
F
|
V
|
50 |
I
|
G
|
V
|
L
|
D
|
N
|
L
|
L
|
V
|
V
|
60 |
ICL1 | |||||||||
L
|
I
|
L
|
V
|
K
|
Y
|
K
|
G
|
L
|
K
|
70 |
TM2 | |||||||||
R
|
V
|
E
|
N
|
I
|
Y
|
L
|
L
|
N
|
L
|
80 |
A
|
V
|
S
|
N
|
L
|
C
|
F
|
L
|
L
|
T
|
90 |
L
|
P
|
F
|
W
|
A
|
H
|
A
|
G
|
G
|
D
|
100 |
ECL1 | TM3 | ||||||||
P
|
M
|
C
|
K
|
I
|
L
|
I
|
G
|
L
|
Y
|
110 |
F
|
V
|
G
|
L
|
Y
|
S
|
E
|
T
|
F
|
F
|
120 |
N
|
C
|
L
|
L
|
T
|
V
|
Q
|
R
|
Y
|
L
|
130 |
ICL2 | |||||||||
V
|
F
|
L
|
H
|
K
|
G
|
N
|
F
|
F
|
S
|
140 |
TM4 | |||||||||
A
|
R
|
R
|
R
|
V
|
P
|
C
|
G
|
I
|
I
|
150 |
T
|
S
|
V
|
L
|
A
|
W
|
V
|
T
|
A
|
I
|
160 |
L
|
A
|
T
|
L
|
P
|
E
|
F
|
V
|
V
|
Y
|
170 |
ECL2 | |||||||||
K
|
P
|
Q
|
M
|
E
|
D
|
Q
|
K
|
Y
|
K
|
180 |
C
|
A
|
F
|
S
|
R
|
T
|
P
|
F
|
L
|
P
|
190 |
TM5 | |||||||||
A
|
D
|
E
|
T
|
F
|
W
|
K
|
H
|
F
|
L
|
200 |
T
|
L
|
K
|
M
|
N
|
I
|
S
|
V
|
L
|
V
|
210 |
L
|
P
|
L
|
F
|
I
|
F
|
T
|
F
|
L
|
Y
|
220 |
V
|
Q
|
M
|
R
|
K
|
T
|
L
|
R
|
F
|
R
|
230 |
ICL3 | TM6 | ||||||||
E
|
Q
|
R
|
Y
|
S
|
L
|
F
|
K
|
L
|
V
|
240 |
F
|
A
|
I
|
M
|
V
|
V
|
F
|
L
|
L
|
M
|
250 |
W
|
A
|
P
|
Y
|
N
|
I
|
A
|
F
|
F
|
L
|
260 |
S
|
T
|
F
|
K
|
E
|
H
|
F
|
S
|
L
|
S
|
270 |
TM7 | |||||||||
D
|
C
|
K
|
S
|
S
|
Y
|
N
|
L
|
D
|
K
|
280 |
S
|
V
|
H
|
I
|
T
|
K
|
L
|
I
|
A
|
T
|
290 |
T
|
H
|
C
|
C
|
I
|
N
|
P
|
L
|
L
|
Y
|
300 |
H8 | |||||||||
A
|
F
|
L
|
D
|
G
|
T
|
F
|
S
|
K
|
Y
|
310 |
L
|
C
|
R
|
C
|
F
|
H
|
L
|
R
|
S
|
N
|
320 |
C-term | |||||||||
T
|
P
|
L
|
Q
|
P
|
R
|
G
|
Q
|
S
|
A
|
330 |
Q
|
G
|
T
|
S
|
R
|
E
|
E
|
P
|
D
|
H
|
340 |
S
|
T
|
E
|
V
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
chemerin C-terminal peptide, CCL19
STRUCTURE MODELS
STRUCTURES
No structures available