GPBA receptor (gpbar_human)
FAMILY
Class A (Rhodopsin) Steroid receptors Bile acid receptors GPBA receptor
GENE
GPBAR1 (TGR5)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, hGPCR19, Membrane-type receptor for bile acids, M-BAR, hBG37, BG37
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
T
|
P
|
N
|
S
|
T
|
G
|
E
|
V
|
P
|
10 |
TM1 | |||||||||
S
|
P
|
I
|
P
|
K
|
G
|
A
|
L
|
G
|
L
|
20 |
S
|
L
|
A
|
L
|
A
|
S
|
L
|
I
|
I
|
T
|
30 |
A
|
N
|
L
|
L
|
L
|
A
|
L
|
G
|
I
|
A
|
40 |
ICL1 | TM2 | ||||||||
W
|
D
|
R
|
R
|
L
|
R
|
S
|
P
|
P
|
A
|
50 |
G
|
C
|
F
|
F
|
L
|
S
|
L
|
L
|
L
|
A
|
60 |
G
|
L
|
L
|
T
|
G
|
L
|
A
|
L
|
P
|
T
|
70 |
ECL1 | |||||||||
L
|
P
|
G
|
L
|
W
|
N
|
Q
|
S
|
R
|
R
|
80 |
TM3 | |||||||||
G
|
Y
|
W
|
S
|
C
|
L
|
L
|
V
|
Y
|
L
|
90 |
A
|
P
|
N
|
F
|
S
|
F
|
L
|
S
|
L
|
L
|
100 |
A
|
N
|
L
|
L
|
L
|
V
|
H
|
G
|
E
|
R
|
110 |
ICL2 | |||||||||
Y
|
M
|
A
|
V
|
L
|
R
|
P
|
L
|
Q
|
P
|
120 |
TM4 | |||||||||
P
|
G
|
S
|
I
|
R
|
L
|
A
|
L
|
L
|
L
|
130 |
T
|
W
|
A
|
G
|
P
|
L
|
L
|
F
|
A
|
S
|
140 |
ECL2 | |||||||||
L
|
P
|
A
|
L
|
G
|
W
|
N
|
H
|
W
|
T
|
150 |
P
|
G
|
A
|
N
|
C
|
S
|
S
|
Q
|
A
|
I
|
160 |
TM5 | |||||||||
F
|
P
|
A
|
P
|
Y
|
L
|
Y
|
L
|
E
|
V
|
170 |
Y
|
G
|
L
|
L
|
L
|
P
|
A
|
V
|
G
|
A
|
180 |
A
|
A
|
F
|
L
|
S
|
V
|
R
|
V
|
L
|
A
|
190 |
T
|
A
|
H
|
R
|
Q
|
L
|
Q
|
D
|
I
|
C
|
200 |
R
|
L
|
E
|
R
|
A
|
V
|
C
|
R
|
D
|
E
|
210 |
ICL3 | TM6 | ||||||||
P
|
S
|
A
|
L
|
A
|
R
|
A
|
L
|
T
|
W
|
220 |
R
|
Q
|
A
|
R
|
A
|
Q
|
A
|
G
|
A
|
M
|
230 |
L
|
L
|
F
|
G
|
L
|
C
|
W
|
G
|
P
|
Y
|
240 |
V
|
A
|
T
|
L
|
L
|
L
|
S
|
V
|
L
|
A
|
250 |
ECL3 | TM7 | ||||||||
Y
|
E
|
Q
|
R
|
P
|
P
|
L
|
G
|
P
|
G
|
260 |
T
|
L
|
L
|
S
|
L
|
L
|
S
|
L
|
G
|
S
|
270 |
A
|
S
|
A
|
A
|
A
|
V
|
P
|
V
|
A
|
M
|
280 |
H8 | |||||||||
G
|
L
|
G
|
D
|
Q
|
R
|
Y
|
T
|
A
|
P
|
290 |
W
|
R
|
A
|
A
|
A
|
Q
|
R
|
C
|
L
|
Q
|
300 |
C-term | |||||||||
G
|
L
|
W
|
G
|
R
|
A
|
S
|
R
|
D
|
S
|
310 |
P
|
G
|
P
|
S
|
I
|
A
|
Y
|
H
|
P
|
S
|
320 |
S
|
Q
|
S
|
S
|
V
|
D
|
L
|
D
|
L
|
N
|
330 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
cholic acid, deoxycholic acid, chenodeoxycholic acid, lithocholic acid
STRUCTURE MODELS
STRUCTURES
Found 4 structure(s) - view all details on the Structures page