GPBA receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XTQ

RESOLUTION

3.2 Å

REFERENCE

10.1073/PNAS.2117054119

PUBLICATION DATE

July 6, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

33 interactions (Click to see)

LIGANDS

CHEMBL2181246 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

cholic acid, deoxycholic acid, chenodeoxycholic acid, lithocholic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 118 - G.H5 I 383 G.H5.15
Hydrophobic TM5 V 206 5x79 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 V 206 5x79 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 A 192 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 202 5x75 G.H4 R 342 G.H4.12
Hydrophobic TM5 V 206 5x79 G.H4 L 346 G.H4.16
Hydrophobic TM6 L 214 6x25 G.h4s6 D 354 G.h4s6.10
Hydrophobic TM6 A 225 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 225 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 117 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 117 - G.H5 I 383 G.H5.15
Polar H8 R 286 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 R 286 8x49 G.H5 Q 390 G.H5.22
Hydrophobic TM5 V 206 5x79 G.H4 R 347 G.H4.17
Van-der-waals TM5 V 206 5x79 G.H4 R 347 G.H4.17
Polar TM3 A 113 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 113 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 113 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 R 110 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 110 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 199 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 199 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 117 - G.H5 R 380 G.H5.12
Hydrophobic TM3 V 114 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 114 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 Q 195 5x68 G.H5 L 394 G.H5.26
Van-der-waals TM5 Q 195 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 214 6x25 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM6 L 214 6x25 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM5 A 192 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 A 192 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 118 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 118 - G.S1 H 41 G.S1.02
Hydrophobic TM5 L 196 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 T 191 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 199 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 199 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 199 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM2 A 50 2x39 G.H5 Y 391 G.H5.23
Polar TM3 L 115 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 L 115 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM5 V 188 5x61 G.H5 L 393 G.H5.25
Polar TM5 Q 195 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 195 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM3 A 113 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 R 208 - G.hgh4 P 321 G.hgh4.11
Van-der-waals ICL3 R 208 - G.hgh4 P 321 G.hgh4.11
Ionic TM6 R 221 6x32 G.H5 E 392 G.H5.24
Polar TM6 R 221 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 221 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 221 6x32 G.H5 E 392 G.H5.24
Polar TM6 R 221 6x32 G.H5 L 394 G.H5.26
Ionic H8 R 286 8x49 G.H5 E 392 G.H5.24
Polar H8 R 286 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM5 A 205 5x78 G.hgh4 P 321 G.hgh4.11
Polar TM3 V 114 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 114 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 114 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 R 221 6x32 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 218 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 L 218 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM6 Q 222 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 Q 222 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 214 6x25 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 L 202 5x75 G.S6 P 361 G.S6.03
Polar TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 118 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 118 - G.S3 V 217 G.S3.01
Polar TM5 Q 195 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 Q 195 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 Q 195 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 E 203 5x76 G.h4s6 T 350 G.h4s6.03
Polar TM5 Q 195 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 195 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 195 5x68 G.H5 R 385 G.H5.17
Polar TM6 Q 222 6x33 G.H5 L 394 G.H5.26
Ionic TM5 D 198 5x71 G.H5 R 385 G.H5.17
Polar TM5 D 198 5x71 G.H5 R 385 G.H5.17
Van-der-waals TM5 D 198 5x71 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 118 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 118 - G.H5 F 376 G.H5.08
Hydrophobic TM5 Q 195 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM5 T 191 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 T 191 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 202 5x75 G.H4 L 346 G.H4.16
Hydrophobic ICL2 L 118 - G.H5 R 380 G.H5.12
Hydrophobic TM3 V 114 3x54 G.H5 Y 391 G.H5.23
Polar ICL3 R 208 - G.hgh4 T 319 G.hgh4.09