GPBA receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.9 Å

REFERENCE

PUBLICATION DATE

Sept. 2, 2020

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

No ligands

ENDOGENOUS LIGANDS

cholic acid, deoxycholic acid, lithocholic acid, chenodeoxycholic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 L 118 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 118 - G.H5 R 380 G.H5.12
Polar TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 117 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 117 - G.H5 I 383 G.H5.15
Ionic TM5 D 198 5x71 G.H5 R 385 G.H5.17
Polar TM5 D 198 5x71 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 189 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 199 5x72 G.H5 L 394 G.H5.26
Van-der-waals TM5 Q 195 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM3 V 114 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 R 110 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 199 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM6 Q 222 6x33 G.H5 L 394 G.H5.26
Hydrophobic TM5 V 188 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 117 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 117 - G.H5 R 380 G.H5.12
Polar TM3 A 113 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 113 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 V 114 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 114 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 196 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 V 206 5x79 G.h4s6 T 350 G.h4s6.03
Polar TM6 Q 222 6x33 G.H5 E 392 G.H5.24
Hydrophobic TM6 Q 222 6x33 G.H5 E 392 G.H5.24
Van-der-waals TM6 Q 222 6x33 G.H5 E 392 G.H5.24
Hydrophobic TM5 V 206 5x79 G.H4 R 347 G.H4.17
Hydrophobic TM5 V 206 5x79 G.H4 L 346 G.H4.16
Hydrophobic TM5 A 192 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM3 R 110 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 110 3x50 G.H5 Y 391 G.H5.23