GPBA receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9GYO

RESOLUTION

2.5 Å

REFERENCE

PUBLICATION DATE

Oct. 9, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

41 interactions (Click to see)

LIGANDS

CHEMBL2331646 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

cholic acid, deoxycholic acid, chenodeoxycholic acid, lithocholic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 Q 195 5x68 G.H5 Q 363 G.H5.16
Van-der-waals TM5 Q 195 5x68 G.H5 Q 363 G.H5.16
Hydrophobic TM3 A 113 3x53 G.H5 Y 370 G.H5.23
Hydrophobic TM5 A 192 5x65 G.H5 L 372 G.H5.25
Hydrophobic ICL2 P 117 - G.H5 Q 363 G.H5.16
Hydrophobic ICL2 L 118 - G.H5 F 355 G.H5.08
Van-der-waals ICL2 L 118 - G.H5 F 355 G.H5.08
Hydrophobic TM5 V 206 5x79 G.H4 D 322 G.H4.13
Hydrophobic TM5 L 202 5x75 G.S6 P 340 G.S6.03
Polar TM3 A 113 3x53 G.H5 H 366 G.H5.19
Hydrophobic TM3 A 113 3x53 G.H5 H 366 G.H5.19
Van-der-waals TM3 A 113 3x53 G.H5 H 366 G.H5.19
Hydrophobic TM5 L 196 5x69 G.H5 L 373 G.H5.26
Hydrophobic TM5 I 199 5x72 G.H5 L 373 G.H5.26
Hydrophobic TM5 I 199 5x72 G.h4s6 Y 337 G.h4s6.20
Van-der-waals TM5 I 199 5x72 G.h4s6 Y 337 G.h4s6.20
Hydrophobic ICL2 L 118 - G.H5 R 359 G.H5.12
Van-der-waals ICL2 L 118 - G.H5 R 359 G.H5.12
Polar ICL3 R 208 - G.hgh4 T 298 G.hgh4.09
Van-der-waals ICL3 R 208 - G.hgh4 T 298 G.hgh4.09
Hydrophobic ICL2 L 118 - G.H5 I 362 G.H5.15
Polar TM3 L 115 3x55 G.H5 R 359 G.H5.12
Van-der-waals TM3 L 115 3x55 G.H5 R 359 G.H5.12
Hydrophobic TM5 E 203 5x76 G.h4s6 T 329 G.h4s6.03
Ionic H8 R 286 8x49 G.H5 E 371 G.H5.24
Polar H8 R 286 8x49 G.H5 E 371 G.H5.24
Hydrophobic H8 R 286 8x49 G.H5 E 371 G.H5.24
Van-der-waals H8 R 286 8x49 G.H5 E 371 G.H5.24
Hydrophobic ICL2 L 118 - G.S1 H 34 G.S1.02
Van-der-waals ICL2 L 118 - G.S1 H 34 G.S1.02
Hydrophobic TM5 L 189 5x62 G.H5 L 372 G.H5.25
Polar TM6 R 221 6x32 G.H5 L 373 G.H5.26
Polar TM3 E 109 3x49 G.H5 Y 370 G.H5.23
Hydrophobic TM3 E 109 3x49 G.H5 Y 370 G.H5.23
Van-der-waals TM3 E 109 3x49 G.H5 Y 370 G.H5.23
Hydrophobic TM5 L 202 5x75 G.H4 R 321 G.H4.12
Hydrophobic ICL2 P 117 - G.H5 H 366 G.H5.19
Hydrophobic TM5 I 199 5x72 G.H5 R 364 G.H5.17
Van-der-waals TM5 I 199 5x72 G.H5 R 364 G.H5.17
Hydrophobic TM2 A 50 2x39 G.H5 Y 370 G.H5.23
Hydrophobic TM5 Q 195 5x68 G.H5 L 373 G.H5.26
Hydrophobic TM5 T 191 5x64 G.H5 Q 363 G.H5.16
Van-der-waals TM5 T 191 5x64 G.H5 Q 363 G.H5.16
Polar TM5 R 194 5x67 G.H5 Q 363 G.H5.16
Van-der-waals TM5 R 194 5x67 G.H5 Q 363 G.H5.16
Hydrophobic TM5 V 206 5x79 G.H4 L 325 G.H4.16
Van-der-waals TM5 V 206 5x79 G.H4 L 325 G.H4.16
Ionic TM5 R 204 5x77 G.hgh4 D 302 G.hgh4.13
Polar TM5 R 204 5x77 G.hgh4 D 302 G.hgh4.13
Van-der-waals TM5 R 204 5x77 G.hgh4 D 302 G.hgh4.13
Hydrophobic TM3 V 114 3x54 G.H5 L 367 G.H5.20
Hydrophobic TM6 R 221 6x32 G.H5 L 372 G.H5.25
Polar H8 R 286 8x49 G.H5 Q 369 G.H5.22
Van-der-waals H8 R 286 8x49 G.H5 Q 369 G.H5.22
Hydrophobic TM5 R 201 5x74 G.hgh4 D 302 G.hgh4.13
Van-der-waals TM5 A 205 5x78 G.H4 R 321 G.H4.12
Hydrophobic TM5 L 202 5x75 G.H4 L 325 G.H4.16
Hydrophobic TM5 V 206 5x79 G.h4s6 T 329 G.h4s6.03
Van-der-waals TM5 V 206 5x79 G.h4s6 T 329 G.h4s6.03
Polar TM3 V 114 3x54 G.H5 Q 363 G.H5.16
Hydrophobic TM3 V 114 3x54 G.H5 Q 363 G.H5.16
Van-der-waals TM3 V 114 3x54 G.H5 Q 363 G.H5.16
Hydrophobic TM6 L 214 6x25 G.h4s6 D 333 G.h4s6.10
Hydrophobic ICL2 L 118 - G.S3 V 196 G.S3.01
Ionic ICL3 R 208 - G.H4 D 322 G.H4.13
Hydrophobic TM5 Q 195 5x68 G.H5 L 367 G.H5.20
Hydrophobic TM6 L 214 6x25 G.h4s6 G 334 G.h4s6.11
Hydrophobic TM6 R 221 6x32 G.H5 E 371 G.H5.24
Van-der-waals TM6 R 221 6x32 G.H5 E 371 G.H5.24
Polar TM5 Q 195 5x68 G.H5 R 364 G.H5.17
Hydrophobic TM5 Q 195 5x68 G.H5 R 364 G.H5.17
Van-der-waals TM5 Q 195 5x68 G.H5 R 364 G.H5.17
Aromatic TM3 R 110 3x50 G.H5 Y 370 G.H5.23
Hydrophobic TM3 R 110 3x50 G.H5 Y 370 G.H5.23
Van-der-waals TM3 R 110 3x50 G.H5 Y 370 G.H5.23
Hydrophobic TM5 A 192 5x65 G.H5 L 367 G.H5.20
Van-der-waals TM6 Q 222 6x33 G.H5 L 373 G.H5.26
Hydrophobic TM6 A 225 6x36 G.H5 L 372 G.H5.25
Van-der-waals TM6 A 225 6x36 G.H5 L 372 G.H5.25
Polar TM5 Q 195 5x68 G.H5 D 360 G.H5.13
Hydrophobic TM5 V 188 5x61 G.H5 L 372 G.H5.25
Van-der-waals TM5 V 188 5x61 G.H5 L 372 G.H5.25
Hydrophobic TM5 V 206 5x79 G.H4 R 326 G.H4.17
Ionic TM5 R 194 5x67 G.H5 D 360 G.H5.13
Aromatic ICL3 R 208 - G.hgh4 Y 297 G.hgh4.08
Hydrophobic ICL3 R 208 - G.hgh4 P 300 G.hgh4.11
Hydrophobic TM6 L 214 6x25 G.h4s6 Y 337 G.h4s6.20
Hydrophobic TM6 L 218 6x29 G.H5 L 373 G.H5.26
Van-der-waals TM6 L 218 6x29 G.H5 L 373 G.H5.26
Polar TM6 Q 222 6x33 G.H5 L 372 G.H5.25
Hydrophobic TM6 Q 222 6x33 G.H5 L 372 G.H5.25
Van-der-waals TM6 Q 222 6x33 G.H5 L 372 G.H5.25
Hydrophobic ICL2 P 117 - G.H5 I 362 G.H5.15
Van-der-waals ICL2 P 117 - G.H5 I 362 G.H5.15
Hydrophobic TM3 V 114 3x54 G.H5 Y 370 G.H5.23
Hydrophobic ICL2 P 117 - G.H5 R 359 G.H5.12