GPBA receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7CFM

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41586-020-2569-1

PUBLICATION DATE

Sept. 9, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

38 interactions (Click to see)

LIGANDS

CHEMBL2331646 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

cholic acid, deoxycholic acid, chenodeoxycholic acid, lithocholic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM5 Q 195 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 195 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 195 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM3 V 114 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 114 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 Q 195 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 Q 195 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM6 A 225 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 225 6x36 G.H5 L 393 G.H5.25
Polar C-term R 286 - G.H5 Q 390 G.H5.22
Hydrophobic C-term R 286 - G.H5 Q 390 G.H5.22
Van-der-waals C-term R 286 - G.H5 Q 390 G.H5.22
Hydrophobic TM5 T 191 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 T 191 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 V 206 5x79 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 V 206 5x79 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 L 218 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 L 218 6x29 G.H5 L 394 G.H5.26
Polar TM6 R 221 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 221 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 221 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 202 5x75 G.S6 P 361 G.S6.03
Polar ICL3 R 208 - G.hgh4 T 319 G.hgh4.09
Hydrophobic TM2 A 50 2x39 G.H5 Y 391 G.H5.23
Polar TM5 Q 195 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 V 206 5x79 G.H4 L 346 G.H4.16
Van-der-waals TM5 V 206 5x79 G.H4 L 346 G.H4.16
Polar TM6 Q 222 6x33 G.H5 L 394 G.H5.26
Hydrophobic TM5 A 192 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM6 Q 222 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 Q 222 6x33 G.H5 L 393 G.H5.25
Polar TM3 V 114 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 118 - G.H5 R 380 G.H5.12
Hydrophobic TM5 I 199 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 199 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 199 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 V 188 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 188 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 118 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 118 - G.H5 F 376 G.H5.08
Polar TM3 A 113 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 113 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 113 3x53 G.H5 H 387 G.H5.19
Ionic C-term R 286 - G.H5 E 392 G.H5.24
Polar C-term R 286 - G.H5 E 392 G.H5.24
Hydrophobic C-term R 286 - G.H5 E 392 G.H5.24
Van-der-waals C-term R 286 - G.H5 E 392 G.H5.24
Hydrophobic TM5 V 206 5x79 G.H4 R 347 G.H4.17
Hydrophobic TM6 L 214 6x25 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM6 L 214 6x25 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM6 L 214 6x25 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 R 221 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 221 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 117 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 117 - G.H5 R 380 G.H5.12
Aromatic TM3 R 110 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 110 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 110 3x50 G.H5 Y 391 G.H5.23
Polar TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 109 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 118 - G.H5 I 383 G.H5.15
Hydrophobic TM5 A 192 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 D 198 5x71 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 195 5x68 G.H5 L 394 G.H5.26
Van-der-waals TM5 Q 195 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 202 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM6 R 221 6x32 G.H5 L 393 G.H5.25
Hydrophobic TM3 V 114 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 113 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 113 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 199 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 199 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM5 Q 195 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 195 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 195 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 118 - G.S3 V 217 G.S3.01
Polar TM3 L 115 3x55 G.H5 R 380 G.H5.12
Hydrophobic TM5 E 203 5x76 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 E 203 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 P 117 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 117 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 118 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 118 - G.S1 H 41 G.S1.02
Hydrophobic TM5 L 189 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 214 6x25 G.h4s6 D 354 G.h4s6.10