α2A-adrenoceptor (ada2a_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors Adrenoceptors α2A-adrenoceptor
GENE
ADRA2A (ADRA2R, ADRAR)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Alpha-2A adrenergic receptor, Alpha-2 adrenergic receptor subtype C10, Alpha-2A adrenoreceptor, Alpha-2A adrenoceptor, Alpha-2AAR
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
F
|
R
|
Q
|
E
|
Q
|
P
|
L
|
A
|
E
|
10 |
G
|
S
|
F
|
A
|
P
|
M
|
G
|
S
|
L
|
Q
|
20 |
P
|
D
|
A
|
G
|
N
|
A
|
S
|
W
|
N
|
G
|
30 |
T
|
E
|
A
|
P
|
G
|
G
|
G
|
A
|
R
|
A
|
40 |
TM1 | |||||||||
T
|
P
|
Y
|
S
|
L
|
Q
|
V
|
T
|
L
|
T
|
50 |
L
|
V
|
C
|
L
|
A
|
G
|
L
|
L
|
M
|
L
|
60 |
L
|
T
|
V
|
F
|
G
|
N
|
V
|
L
|
V
|
I
|
70 |
ICL1 | |||||||||
I
|
A
|
V
|
F
|
T
|
S
|
R
|
A
|
L
|
K
|
80 |
TM2 | |||||||||
A
|
P
|
Q
|
N
|
L
|
F
|
L
|
V
|
S
|
L
|
90 |
A
|
S
|
A
|
D
|
I
|
L
|
V
|
A
|
T
|
L
|
100 |
V
|
I
|
P
|
F
|
S
|
L
|
A
|
N
|
E
|
V
|
110 |
ECL1 | TM3 | ||||||||
M
|
G
|
Y
|
W
|
Y
|
F
|
G
|
K
|
A
|
W
|
120 |
C
|
E
|
I
|
Y
|
L
|
A
|
L
|
D
|
V
|
L
|
130 |
F
|
C
|
T
|
S
|
S
|
I
|
V
|
H
|
L
|
C
|
140 |
A
|
I
|
S
|
L
|
D
|
R
|
Y
|
W
|
S
|
I
|
150 |
ICL2 | |||||||||
T
|
Q
|
A
|
I
|
E
|
Y
|
N
|
L
|
K
|
R
|
160 |
TM4 | |||||||||
T
|
P
|
R
|
R
|
I
|
K
|
A
|
I
|
I
|
I
|
170 |
T
|
V
|
W
|
V
|
I
|
S
|
A
|
V
|
I
|
S
|
180 |
ECL2 | |||||||||
F
|
P
|
P
|
L
|
I
|
S
|
I
|
E
|
K
|
K
|
190 |
G
|
G
|
G
|
G
|
G
|
P
|
Q
|
P
|
A
|
E
|
200 |
TM5 | |||||||||
P
|
R
|
C
|
E
|
I
|
N
|
D
|
Q
|
K
|
W
|
210 |
Y
|
V
|
I
|
S
|
S
|
C
|
I
|
G
|
S
|
F
|
220 |
F
|
A
|
P
|
C
|
L
|
I
|
M
|
I
|
L
|
V
|
230 |
Y
|
V
|
R
|
I
|
Y
|
Q
|
I
|
A
|
K
|
R
|
240 |
R
|
T
|
R
|
V
|
P
|
P
|
S
|
R
|
R
|
G
|
250 |
ICL3 | |||||||||
P
|
D
|
A
|
V
|
A
|
A
|
P
|
P
|
G
|
G
|
260 |
T
|
E
|
R
|
R
|
P
|
N
|
G
|
L
|
G
|
P
|
270 |
E
|
R
|
S
|
A
|
G
|
P
|
G
|
G
|
A
|
E
|
280 |
A
|
E
|
P
|
L
|
P
|
T
|
Q
|
L
|
N
|
G
|
290 |
A
|
P
|
G
|
E
|
P
|
A
|
P
|
A
|
G
|
P
|
300 |
R
|
D
|
T
|
D
|
A
|
L
|
D
|
L
|
E
|
E
|
310 |
S
|
S
|
S
|
S
|
D
|
H
|
A
|
E
|
R
|
P
|
320 |
P
|
G
|
P
|
R
|
R
|
P
|
E
|
R
|
G
|
P
|
330 |
R
|
G
|
K
|
G
|
K
|
A
|
R
|
A
|
S
|
Q
|
340 |
V
|
K
|
P
|
G
|
D
|
S
|
L
|
P
|
R
|
R
|
350 |
G
|
P
|
G
|
A
|
T
|
G
|
I
|
G
|
T
|
P
|
360 |
A
|
A
|
G
|
P
|
G
|
E
|
E
|
R
|
V
|
G
|
370 |
TM6 | |||||||||
A
|
A
|
K
|
A
|
S
|
R
|
W
|
R
|
G
|
R
|
380 |
Q
|
N
|
R
|
E
|
K
|
R
|
F
|
T
|
F
|
V
|
390 |
L
|
A
|
V
|
V
|
I
|
G
|
V
|
F
|
V
|
V
|
400 |
C
|
W
|
F
|
P
|
F
|
F
|
F
|
T
|
Y
|
T
|
410 |
ECL3 | |||||||||
L
|
T
|
A
|
V
|
G
|
C
|
S
|
V
|
P
|
R
|
420 |
TM7 | |||||||||
T
|
L
|
F
|
K
|
F
|
F
|
F
|
W
|
F
|
G
|
430 |
Y
|
C
|
N
|
S
|
S
|
L
|
N
|
P
|
V
|
I
|
440 |
H8 | |||||||||
Y
|
T
|
I
|
F
|
N
|
H
|
D
|
F
|
R
|
R
|
450 |
A
|
F
|
K
|
K
|
I
|
L
|
C
|
R
|
G
|
D
|
460 |
C-term | |||||
R
|
K
|
R
|
I
|
V
|
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
(-)-noradrenaline, (-)-adrenaline