α2A-adrenoceptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7W6P

RESOLUTION

3.5 Å

REFERENCE

10.1126/SCIENCE.ABN7065

PUBLICATION DATE

Sept. 28, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

25 interactions (Click to see)

LIGANDS

N-pyridin-4-ylisoquinolin-4-amine - Agonist pubchem

PHYSIOLOGICAL LIGANDS

(-)-noradrenaline, (-)-adrenaline



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 150 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 150 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 R 241 5x68 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 391 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 391 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 F 387 6x33 G.H5 Y 354 G.H5.26
Van-der-waals TM6 F 387 6x33 G.H5 Y 354 G.H5.26
Polar H8 N 445 8x47 G.H5 G 350 G.H5.22
Hydrophobic TM5 R 241 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 241 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 I 154 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 I 154 34x51 G.S3 L 195 G.S3.01
Polar TM3 S 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 149 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 F 387 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 F 387 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 154 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM5 R 241 5x68 G.H5 A 345 G.H5.17
Van-der-waals TM5 R 241 5x68 G.H5 A 345 G.H5.17
Hydrophobic TM5 A 238 5x65 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 158 34x55 G.hns1 K 32 G.hns1.03
Ionic ICL1 R 77 12x48 G.h2s4 D 218 G.h2s4.03
Hydrophobic ICL2 L 158 34x55 G.s2s3 N 194 G.s2s3.02
Ionic TM5 R 241 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 241 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 241 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 241 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 V 390 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL2 I 154 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 154 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 I 234 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 153 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 153 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM3 I 150 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM6 R 386 6x32 G.H5 Y 354 G.H5.26
Polar ICL2 N 157 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 I 154 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 I 154 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM5 I 234 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL4 F 444 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 F 444 - G.H5 G 352 G.H5.24
Polar TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 146 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 150 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 150 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 153 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 390 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 150 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 150 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 158 34x55 G.S3 L 195 G.S3.01
Hydrophobic TM4 P 162 4x39 G.HN I 28 G.HN.52
Van-der-waals TM4 P 162 4x39 G.HN I 28 G.HN.52