GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

April 13, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

ENDOGENOUS LIGANDS

(-)-adrenaline, (-)-noradrenaline



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 F 387 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 F 387 6x33 G.H5 L 353 G.H5.25
Ionic TM5 R 241 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 241 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 241 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 I 154 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 A 153 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 390 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 390 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 390 6x36 G.H5 G 352 G.H5.24
Polar TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 146 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 150 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 150 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM7 F 444 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 F 444 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL2 I 154 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 I 154 34x51 G.H5 I 343 G.H5.15
Hydrophobic H8 H 446 8x48 G.H5 Y 354 G.H5.26
Polar TM3 S 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 149 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 149 3x53 G.H5 N 347 G.H5.19
Polar ICL2 N 157 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 N 157 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 A 153 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 I 154 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM3 I 150 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 150 3x54 G.H5 L 348 G.H5.20
Polar ICL2 L 158 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 L 158 34x55 G.hns1 K 32 G.hns1.03