CaS receptor (casr_human)
FAMILY
Class C (Glutamate) Ion receptors Calcium-sensing receptors CaS receptor
GENE
CASR (GPRC2A, PCAR1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Extracellular calcium-sensing receptor, CaR, CaSR, hCasR, Parathyroid cell calcium-sensing receptor 1, PCaR1
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
F
|
Y
|
S
|
C
|
C
|
W
|
V
|
L
|
10 |
L
|
A
|
L
|
T
|
W
|
H
|
T
|
S
|
A
|
Y
|
20 |
G
|
P
|
D
|
Q
|
R
|
A
|
Q
|
K
|
K
|
G
|
30 |
D
|
I
|
I
|
L
|
G
|
G
|
L
|
F
|
P
|
I
|
40 |
H
|
F
|
G
|
V
|
A
|
A
|
K
|
D
|
Q
|
D
|
50 |
L
|
K
|
S
|
R
|
P
|
E
|
S
|
V
|
E
|
C
|
60 |
I
|
R
|
Y
|
N
|
F
|
R
|
G
|
F
|
R
|
W
|
70 |
L
|
Q
|
A
|
M
|
I
|
F
|
A
|
I
|
E
|
E
|
80 |
I
|
N
|
S
|
S
|
P
|
A
|
L
|
L
|
P
|
N
|
90 |
L
|
T
|
L
|
G
|
Y
|
R
|
I
|
F
|
D
|
T
|
100 |
C
|
N
|
T
|
V
|
S
|
K
|
A
|
L
|
E
|
A
|
110 |
T
|
L
|
S
|
F
|
V
|
A
|
Q
|
N
|
K
|
I
|
120 |
D
|
S
|
L
|
N
|
L
|
D
|
E
|
F
|
C
|
N
|
130 |
C
|
S
|
E
|
H
|
I
|
P
|
S
|
T
|
I
|
A
|
140 |
V
|
V
|
G
|
A
|
T
|
G
|
S
|
G
|
V
|
S
|
150 |
T
|
A
|
V
|
A
|
N
|
L
|
L
|
G
|
L
|
F
|
160 |
Y
|
I
|
P
|
Q
|
V
|
S
|
Y
|
A
|
S
|
S
|
170 |
S
|
R
|
L
|
L
|
S
|
N
|
K
|
N
|
Q
|
F
|
180 |
K
|
S
|
F
|
L
|
R
|
T
|
I
|
P
|
N
|
D
|
190 |
E
|
H
|
Q
|
A
|
T
|
A
|
M
|
A
|
D
|
I
|
200 |
I
|
E
|
Y
|
F
|
R
|
W
|
N
|
W
|
V
|
G
|
210 |
T
|
I
|
A
|
A
|
D
|
D
|
D
|
Y
|
G
|
R
|
220 |
P
|
G
|
I
|
E
|
K
|
F
|
R
|
E
|
E
|
A
|
230 |
E
|
E
|
R
|
D
|
I
|
C
|
I
|
D
|
F
|
S
|
240 |
E
|
L
|
I
|
S
|
Q
|
Y
|
S
|
D
|
E
|
E
|
250 |
E
|
I
|
Q
|
H
|
V
|
V
|
E
|
V
|
I
|
Q
|
260 |
N
|
S
|
T
|
A
|
K
|
V
|
I
|
V
|
V
|
F
|
270 |
S
|
S
|
G
|
P
|
D
|
L
|
E
|
P
|
L
|
I
|
280 |
K
|
E
|
I
|
V
|
R
|
R
|
N
|
I
|
T
|
G
|
290 |
K
|
I
|
W
|
L
|
A
|
S
|
E
|
A
|
W
|
A
|
300 |
S
|
S
|
S
|
L
|
I
|
A
|
M
|
P
|
Q
|
Y
|
310 |
F
|
H
|
V
|
V
|
G
|
G
|
T
|
I
|
G
|
F
|
320 |
A
|
L
|
K
|
A
|
G
|
Q
|
I
|
P
|
G
|
F
|
330 |
R
|
E
|
F
|
L
|
K
|
K
|
V
|
H
|
P
|
R
|
340 |
K
|
S
|
V
|
H
|
N
|
G
|
F
|
A
|
K
|
E
|
350 |
F
|
W
|
E
|
E
|
T
|
F
|
N
|
C
|
H
|
L
|
360 |
Q
|
E
|
G
|
A
|
K
|
G
|
P
|
L
|
P
|
V
|
370 |
D
|
T
|
F
|
L
|
R
|
G
|
H
|
E
|
E
|
S
|
380 |
G
|
D
|
R
|
F
|
S
|
N
|
S
|
S
|
T
|
A
|
390 |
F
|
R
|
P
|
L
|
C
|
T
|
G
|
D
|
E
|
N
|
400 |
I
|
S
|
S
|
V
|
E
|
T
|
P
|
Y
|
I
|
D
|
410 |
Y
|
T
|
H
|
L
|
R
|
I
|
S
|
Y
|
N
|
V
|
420 |
Y
|
L
|
A
|
V
|
Y
|
S
|
I
|
A
|
H
|
A
|
430 |
L
|
Q
|
D
|
I
|
Y
|
T
|
C
|
L
|
P
|
G
|
440 |
R
|
G
|
L
|
F
|
T
|
N
|
G
|
S
|
C
|
A
|
450 |
D
|
I
|
K
|
K
|
V
|
E
|
A
|
W
|
Q
|
V
|
460 |
L
|
K
|
H
|
L
|
R
|
H
|
L
|
N
|
F
|
T
|
470 |
N
|
N
|
M
|
G
|
E
|
Q
|
V
|
T
|
F
|
D
|
480 |
E
|
C
|
G
|
D
|
L
|
V
|
G
|
N
|
Y
|
S
|
490 |
I
|
I
|
N
|
W
|
H
|
L
|
S
|
P
|
E
|
D
|
500 |
G
|
S
|
I
|
V
|
F
|
K
|
E
|
V
|
G
|
Y
|
510 |
Y
|
N
|
V
|
Y
|
A
|
K
|
K
|
G
|
E
|
R
|
520 |
L
|
F
|
I
|
N
|
E
|
E
|
K
|
I
|
L
|
W
|
530 |
S
|
G
|
F
|
S
|
R
|
E
|
V
|
P
|
F
|
S
|
540 |
N
|
C
|
S
|
R
|
D
|
C
|
L
|
A
|
G
|
T
|
550 |
R
|
K
|
G
|
I
|
I
|
E
|
G
|
E
|
P
|
T
|
560 |
C
|
C
|
F
|
E
|
C
|
V
|
E
|
C
|
P
|
D
|
570 |
G
|
E
|
Y
|
S
|
D
|
E
|
T
|
D
|
A
|
S
|
580 |
A
|
C
|
N
|
K
|
C
|
P
|
D
|
D
|
F
|
W
|
590 |
S
|
N
|
E
|
N
|
H
|
T
|
S
|
C
|
I
|
A
|
600 |
K
|
E
|
I
|
E
|
F
|
L
|
S
|
W
|
T
|
E
|
610 |
TM1 | |||||||||
P
|
F
|
G
|
I
|
A
|
L
|
T
|
L
|
F
|
A
|
620 |
V
|
L
|
G
|
I
|
F
|
L
|
T
|
A
|
F
|
V
|
630 |
L
|
G
|
V
|
F
|
I
|
K
|
F
|
R
|
N
|
T
|
640 |
ICL1 | TM2 | ||||||||
P
|
I
|
V
|
K
|
A
|
T
|
N
|
R
|
E
|
L
|
650 |
S
|
Y
|
L
|
L
|
L
|
F
|
S
|
L
|
L
|
C
|
660 |
C
|
F
|
S
|
S
|
S
|
L
|
F
|
F
|
I
|
G
|
670 |
ECL1 | TM3 | ||||||||
E
|
P
|
Q
|
D
|
W
|
T
|
C
|
R
|
L
|
R
|
680 |
Q
|
P
|
A
|
F
|
G
|
I
|
S
|
F
|
V
|
L
|
690 |
C
|
I
|
S
|
C
|
I
|
L
|
V
|
K
|
T
|
N
|
700 |
ICL2 | |||||||||
R
|
V
|
L
|
L
|
V
|
F
|
E
|
A
|
K
|
I
|
710 |
P
|
T
|
S
|
F
|
H
|
R
|
K
|
W
|
W
|
G
|
720 |
TM4 | |||||||||
L
|
N
|
L
|
Q
|
F
|
L
|
L
|
V
|
F
|
L
|
730 |
C
|
T
|
F
|
M
|
Q
|
I
|
V
|
I
|
C
|
V
|
740 |
ECL2 | |||||||||
I
|
W
|
L
|
Y
|
T
|
A
|
P
|
P
|
S
|
S
|
750 |
Y
|
R
|
N
|
Q
|
E
|
L
|
E
|
D
|
E
|
I
|
760 |
I
|
F
|
I
|
T
|
C
|
H
|
E
|
G
|
S
|
L
|
770 |
TM5 | |||||||||
M
|
A
|
L
|
G
|
F
|
L
|
I
|
G
|
Y
|
T
|
780 |
C
|
L
|
L
|
A
|
A
|
I
|
C
|
F
|
F
|
F
|
790 |
A
|
F
|
K
|
S
|
R
|
K
|
L
|
P
|
E
|
N
|
800 |
ICL3 | TM6 | ||||||||
F
|
N
|
E
|
A
|
K
|
F
|
I
|
T
|
F
|
S
|
810 |
M
|
L
|
I
|
F
|
F
|
I
|
V
|
W
|
I
|
S
|
820 |
F
|
I
|
P
|
A
|
Y
|
A
|
S
|
T
|
Y
|
G
|
830 |
TM7 | |||||||||
K
|
F
|
V
|
S
|
A
|
V
|
E
|
V
|
I
|
A
|
840 |
I
|
L
|
A
|
A
|
S
|
F
|
G
|
L
|
L
|
A
|
850 |
C
|
I
|
F
|
F
|
N
|
K
|
I
|
Y
|
I
|
I
|
860 |
H8 | |||||||||
L
|
F
|
K
|
P
|
S
|
R
|
N
|
T
|
I
|
E
|
870 |
E
|
V
|
R
|
C
|
S
|
T
|
A
|
A
|
H
|
A
|
880 |
C-term | |||||||||
F
|
K
|
V
|
A
|
A
|
R
|
A
|
T
|
L
|
R
|
890 |
R
|
S
|
N
|
V
|
S
|
R
|
K
|
R
|
S
|
S
|
900 |
S
|
L
|
G
|
G
|
S
|
T
|
G
|
S
|
T
|
P
|
910 |
S
|
S
|
S
|
I
|
S
|
S
|
K
|
S
|
N
|
S
|
920 |
E
|
D
|
P
|
F
|
P
|
Q
|
P
|
E
|
R
|
Q
|
930 |
K
|
Q
|
Q
|
Q
|
P
|
L
|
A
|
L
|
T
|
Q
|
940 |
Q
|
E
|
Q
|
Q
|
Q
|
Q
|
P
|
L
|
T
|
L
|
950 |
P
|
Q
|
Q
|
Q
|
R
|
S
|
Q
|
Q
|
Q
|
P
|
960 |
R
|
C
|
K
|
Q
|
K
|
V
|
I
|
F
|
G
|
S
|
970 |
G
|
T
|
V
|
T
|
F
|
S
|
L
|
S
|
F
|
D
|
980 |
E
|
P
|
Q
|
K
|
N
|
A
|
M
|
A
|
H
|
R
|
990 |
N
|
S
|
T
|
H
|
Q
|
N
|
S
|
L
|
E
|
A
|
1000 |
Q
|
K
|
S
|
S
|
D
|
T
|
L
|
T
|
R
|
H
|
1010 |
E
|
P
|
L
|
L
|
P
|
L
|
Q
|
C
|
G
|
E
|
1020 |
T
|
D
|
L
|
D
|
L
|
T
|
V
|
Q
|
E
|
T
|
1030 |
G
|
L
|
Q
|
G
|
P
|
V
|
G
|
G
|
D
|
Q
|
1040 |
R
|
P
|
E
|
V
|
E
|
D
|
P
|
E
|
E
|
L
|
1050 |
S
|
P
|
A
|
L
|
V
|
V
|
S
|
S
|
S
|
Q
|
1060 |
S
|
F
|
V
|
I
|
S
|
G
|
G
|
G
|
S
|
T
|
1070 |
V
|
T
|
E
|
N
|
V
|
V
|
N
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
Ca2+, spermine, Mg2+, L-tryptophan