B1 receptor (bkrb1_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Bradykinin receptors B1 receptor
GENE
BDKRB1 (BRADYB1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
B1 bradykinin receptor, B1R, BK-1 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
S
|
S
|
W
|
P
|
P
|
L
|
E
|
L
|
10 |
Q
|
S
|
S
|
N
|
Q
|
S
|
Q
|
L
|
F
|
P
|
20 |
Q
|
N
|
A
|
T
|
A
|
C
|
D
|
N
|
A
|
P
|
30 |
TM1 | |||||||||
E
|
A
|
W
|
D
|
L
|
L
|
H
|
R
|
V
|
L
|
40 |
P
|
T
|
F
|
I
|
I
|
S
|
I
|
C
|
F
|
F
|
50 |
G
|
L
|
L
|
G
|
N
|
L
|
F
|
V
|
L
|
L
|
60 |
ICL1 | |||||||||
V
|
F
|
L
|
L
|
P
|
R
|
R
|
Q
|
L
|
N
|
70 |
TM2 | |||||||||
V
|
A
|
E
|
I
|
Y
|
L
|
A
|
N
|
L
|
A
|
80 |
A
|
S
|
D
|
L
|
V
|
F
|
V
|
L
|
G
|
L
|
90 |
P
|
F
|
W
|
A
|
E
|
N
|
I
|
W
|
N
|
Q
|
100 |
ECL1 | TM3 | ||||||||
F
|
N
|
W
|
P
|
F
|
G
|
A
|
L
|
L
|
C
|
110 |
R
|
V
|
I
|
N
|
G
|
V
|
I
|
K
|
A
|
N
|
120 |
L
|
F
|
I
|
S
|
I
|
F
|
L
|
V
|
V
|
A
|
130 |
I
|
S
|
Q
|
D
|
R
|
Y
|
R
|
V
|
L
|
V
|
140 |
ICL2 | |||||||||
H
|
P
|
M
|
A
|
S
|
R
|
R
|
Q
|
Q
|
R
|
150 |
TM4 | |||||||||
R
|
R
|
Q
|
A
|
R
|
V
|
T
|
C
|
V
|
L
|
160 |
I
|
W
|
V
|
V
|
G
|
G
|
L
|
L
|
S
|
I
|
170 |
ECL2 | |||||||||
P
|
T
|
F
|
L
|
L
|
R
|
S
|
I
|
Q
|
A
|
180 |
V
|
P
|
D
|
L
|
N
|
I
|
T
|
A
|
C
|
I
|
190 |
TM5 | |||||||||
L
|
L
|
L
|
P
|
H
|
E
|
A
|
W
|
H
|
F
|
200 |
A
|
R
|
I
|
V
|
E
|
L
|
N
|
I
|
L
|
G
|
210 |
F
|
L
|
L
|
P
|
L
|
A
|
A
|
I
|
V
|
F
|
220 |
F
|
N
|
Y
|
H
|
I
|
L
|
A
|
S
|
L
|
R
|
230 |
T
|
R
|
E
|
E
|
V
|
S
|
R
|
T
|
R
|
C
|
240 |
ICL3 | TM6 | ||||||||
G
|
G
|
R
|
K
|
D
|
S
|
K
|
T
|
T
|
A
|
250 |
L
|
I
|
L
|
T
|
L
|
V
|
V
|
A
|
F
|
L
|
260 |
V
|
C
|
W
|
A
|
P
|
Y
|
H
|
F
|
F
|
A
|
270 |
F
|
L
|
E
|
F
|
L
|
F
|
Q
|
V
|
Q
|
A
|
280 |
ECL3 | TM7 | ||||||||
V
|
R
|
G
|
C
|
F
|
W
|
E
|
D
|
F
|
I
|
290 |
D
|
L
|
G
|
L
|
Q
|
L
|
A
|
N
|
F
|
F
|
300 |
A
|
F
|
T
|
N
|
S
|
S
|
L
|
N
|
P
|
V
|
310 |
H8 | |||||||||
I
|
Y
|
V
|
F
|
V
|
G
|
R
|
L
|
F
|
R
|
320 |
T
|
K
|
V
|
W
|
E
|
L
|
Y
|
K
|
Q
|
C
|
330 |
C-term | |||||||||
T
|
P
|
K
|
S
|
L
|
A
|
P
|
I
|
S
|
S
|
340 |
S
|
H
|
R
|
K
|
E
|
I
|
F
|
Q
|
L
|
F
|
350 |
W
|
R
|
N
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
[des-Arg9]bradykinin, kallidin, Lys-[Hyp3]-bradykinin, [des-Arg10]kallidin, T-kinin, [Hyp3]bradykinin, bradykinin
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 7EIB