V2 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

4.2 Å

REFERENCE

PUBLICATION DATE

June 2, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

ENDOGENOUS LIGANDS

vasopressin, oxytocin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM6 T 269 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 269 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 269 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM7 F 328 7x56 G.H5 L 393 G.H5.25
Van-der-waals TM7 F 328 7x56 G.H5 L 393 G.H5.25
Polar H8 S 329 8x47 G.H5 Y 391 G.H5.23
Hydrophobic H8 S 329 8x47 G.H5 Y 391 G.H5.23
Van-der-waals H8 S 329 8x47 G.H5 Y 391 G.H5.23
Hydrophobic TM7 F 328 7x56 G.H5 L 394 G.H5.26
Van-der-waals TM7 F 328 7x56 G.H5 L 394 G.H5.26
Van-der-waals TM7 F 328 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL3 A 265 - G.H5 L 393 G.H5.25
Van-der-waals ICL3 A 265 - G.H5 L 393 G.H5.25
Polar ICL3 H 261 - G.H5 R 389 G.H5.21
Aromatic ICL3 H 261 - G.H5 R 389 G.H5.21
Hydrophobic ICL3 H 261 - G.H5 R 389 G.H5.21
Polar ICL2 P 144 - G.H5 R 380 G.H5.12
Hydrophobic TM5 E 231 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 E 231 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 I 232 5x65 G.h4s6 Y 358 G.h4s6.20
Polar TM3 R 137 3x50 G.H5 L 394 G.H5.26
Hydrophobic TM3 R 137 3x50 G.H5 L 394 G.H5.26
Van-der-waals TM3 R 137 3x50 G.H5 L 394 G.H5.26
Hydrophobic ICL1 I 74 - G.H5 Q 390 G.H5.22
Van-der-waals ICL1 I 74 - G.H5 Q 390 G.H5.22
Hydrophobic TM5 E 231 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 E 231 5x64 G.H5 Q 384 G.H5.16
Hydrophobic H8 S 329 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 329 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL1 I 74 - G.H5 Y 391 G.H5.23
Hydrophobic TM7 Y 325 7x53 G.H5 L 394 G.H5.26
Polar TM3 I 141 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 141 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 141 3x54 G.H5 Q 384 G.H5.16
Ionic ICL3 H 261 - G.H5 E 392 G.H5.24
Hydrophobic ICL3 H 261 - G.H5 E 392 G.H5.24
Polar TM3 R 143 3x56 G.H5 R 380 G.H5.12
Van-der-waals TM3 R 143 3x56 G.H5 R 380 G.H5.12
Polar ICL1 W 71 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 A 140 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 I 276 6x40 G.H5 L 394 G.H5.26
Van-der-waals TM6 I 276 6x40 G.H5 L 394 G.H5.26
Van-der-waals ICL3 V 262 - G.H5 R 385 G.H5.17
Hydrophobic ICL1 W 71 - G.HN Q 35 G.HN.52
Hydrophobic TM6 M 272 6x36 G.H5 L 393 G.H5.25