V2 receptor (v2r_human)

FAMILY

Class A (Rhodopsin) Peptide receptors Vasopressin and oxytocin receptors V2 receptor

GENE

AVPR2 (ADHR, DIR, DIR3, V2R)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Vasopressin V2 receptor, V2R, AVPR V2, Antidiuretic hormone receptor, Renal-type arginine vasopressin receptor

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
L
M
A
S
T
T
S
A
V
10
                   
P
G
H
P
S
L
P
S
L
P
20
                   
S
N
S
S
Q
E
R
P
L
D
30
    TM1          
T
R
D
P
L
L
A
R
A
E
40
                   
L
A
L
L
S
I
V
F
V
A
50
                   
V
A
L
S
N
G
L
V
L
A
60
                   
A
L
A
R
R
G
R
R
G
H
70
ICL1 TM2      
W
A
P
I
H
V
F
I
G
H
80
                   
L
C
L
A
D
L
A
V
A
L
90
                   
F
Q
V
L
P
Q
L
A
W
K
100
      ECL1 TM3
A
T
D
R
F
R
G
P
D
A
110
                   
L
C
R
A
V
K
Y
L
Q
M
120
                   
V
G
M
Y
A
S
S
Y
M
I
130
                   
L
A
M
T
L
D
R
H
R
A
140
      ICL2      
I
C
R
P
M
L
A
Y
R
H
150
  TM4            
G
S
G
A
H
W
N
R
P
V
160
                   
L
V
A
W
A
F
S
L
L
L
170
                   
S
L
P
Q
L
F
I
F
A
Q
180
ECL2            
R
N
V
E
G
G
S
G
V
T
190
                   
D
C
W
A
C
F
A
E
P
W
200
TM5              
G
R
R
T
Y
V
T
W
I
A
210
                   
L
M
V
F
V
A
P
T
L
G
220
                   
I
A
A
C
Q
V
L
I
F
R
230
                   
E
I
H
A
S
L
V
P
G
P
240
      ICL3      
S
E
R
P
G
G
R
R
R
G
250
                   
R
R
T
G
S
P
G
E
G
A
260
TM6              
H
V
S
A
A
V
A
K
T
V
270
                   
R
M
T
L
V
I
V
V
V
Y
280
                   
V
L
C
W
A
P
F
F
L
V
290
                   
Q
L
W
A
A
W
D
P
E
A
300
ECL3 TM7      
P
L
E
G
A
P
F
V
L
L
310
                   
M
L
L
A
S
L
N
S
C
T
320
                H8
N
P
W
I
Y
A
S
F
S
S
330
                   
S
V
S
S
E
L
R
S
L
L
340
                   
C
C
A
R
G
R
T
P
P
S
350
C-term        
L
G
P
Q
D
E
S
C
T
T
360
                   
A
S
S
S
L
A
K
D
T
S
370
 
S

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

365 mutation data points available.

PHYSIOLOGICAL LIGANDS

oxytocin, vasopressin

STRUCTURE MODELS

v2r_human inactive,

v2r_human active

STRUCTURES

Found 5 structure(s) - view all details on the Structures page

PDBs: 7KH0, 7BB6, 7BB7, 7DW9, 7R0C