V2 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7DW9

RESOLUTION

2.6 Å

REFERENCE

10.1038/S41422-021-00480-2

PUBLICATION DATE

July 21, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

78 interactions (Click to see)

LIGANDS

vasopressin - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

oxytocin, vasopressin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 141 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 141 3x54 G.H5 L 393 G.H5.25
Polar TM3 C 142 3x55 G.H5 R 380 G.H5.12
Hydrophobic ICL2 M 145 - G.H5 C 379 G.H5.11
Hydrophobic TM3 I 141 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 141 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 M 145 - G.H5 F 376 G.H5.08
Hydrophobic TM6 A 265 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM3 R 137 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 M 272 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 272 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 268 6x32 G.H5 L 393 G.H5.25
Polar H8 S 331 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 S 331 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 S 331 8x49 G.H5 E 392 G.H5.24
Polar H8 S 330 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 S 330 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 S 330 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM3 R 137 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 265 6x29 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 140 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 140 3x53 G.H5 Y 391 G.H5.23
Polar TM6 K 268 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 268 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 M 145 - G.S1 H 41 G.S1.02
Polar ICL2 Y 148 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Y 148 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Y 148 - G.hns1 R 38 G.hns1.02
Polar ICL2 P 144 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 144 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 M 145 - G.H5 R 380 G.H5.12
Polar H8 S 329 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 329 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 329 8x47 G.H5 E 392 G.H5.24
Polar TM3 I 141 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 144 - G.H5 R 380 G.H5.12
Hydrophobic TM5 I 232 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 147 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 R 149 - G.HN Q 35 G.HN.52
Ionic TM5 E 231 5x64 G.H5 R 380 G.H5.12
Polar TM5 E 231 5x64 G.H5 R 380 G.H5.12
Van-der-waals TM5 E 231 5x64 G.H5 R 380 G.H5.12
Hydrophobic ICL2 M 145 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 P 144 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 M 145 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 M 145 - G.H5 I 383 G.H5.15
Polar TM3 D 136 3x49 G.H5 Y 391 G.H5.23
Polar TM3 A 140 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 140 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 144 - G.H5 I 383 G.H5.15