PDB
7DW9
Resolution
2.6 Å
Released
July 21, 2021
Receptor
V2
Class
A
Species
Homo sapiens
Ligand
Function
vasopressin (Human)
Agonist
Reference
10.1038/S41422-021-00480-2

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Ligand Amino Acid Generic Number Segment Interaction Type
vasopressin (Human) T31 N-term Van der Waals
vasopressin (Human) R32 N-term Van der Waals
vasopressin (Human) D33 1.28x28 TM1 polar (charge-charge)
vasopressin (Human) D33 1.28x28 TM1 polar (hydrogen bond)
vasopressin (Human) L36 1.31x31 TM1 Van der Waals
vasopressin (Human) A37 1.32x32 TM1 Van der Waals
vasopressin (Human) E40 1.35x35 TM1 polar (hydrogen bond)
vasopressin (Human) E40 1.35x35 TM1 polar (charge-charge)
vasopressin (Human) Q92 2.57x56 TM2 hydrophobic
vasopressin (Human) Q96 2.61x60 TM2 hydrophobic
vasopressin (Human) K100 2.65x64 TM2 Van der Waals
vasopressin (Human) D103 ECL1 polar (hydrogen bond with backbone)
vasopressin (Human) R104 23.49x49 ECL1 Van der Waals
vasopressin (Human) K116 3.29x29 TM3 polar (hydrogen bond)
vasopressin (Human) Q119 3.32x32 TM3 Van der Waals
vasopressin (Human) M120 3.33x33 TM3 hydrophobic
vasopressin (Human) M123 3.36x36 TM3 hydrophobic
vasopressin (Human) Q174 4.60x61 TM4 polar (hydrogen bond)
vasopressin (Human) F178 4.64x65 TM4 Van der Waals
vasopressin (Human) W193 45.51x51 ECL2 Van der Waals
vasopressin (Human) A194 45.52x52 ECL2 polar (hydrogen bond with backbone)
vasopressin (Human) R202 5.35x36 TM5 polar (hydrogen bond)
vasopressin (Human) Y205 5.38x39 TM5 hydrophobic
vasopressin (Human) V206 5.39x40 TM5 hydrophobic
vasopressin (Human) I209 5.42x43 TM5 hydrophobic
vasopressin (Human) F287 6.51x51 TM6 hydrophobic
vasopressin (Human) F288 6.52x52 TM6 Van der Waals
vasopressin (Human) Q291 6.55x55 TM6 hydrophobic
vasopressin (Human) Q291 6.55x55 TM6 polar (hydrogen bond)
vasopressin (Human) A294 6.58x58 TM6 Van der Waals
vasopressin (Human) A295 6.59x59 TM6 Van der Waals
vasopressin (Human) L302 ECL3 hydrophobic
vasopressin (Human) V308 7.36x35 TM7 hydrophobic
vasopressin (Human) M311 7.39x38 TM7 hydrophobic
vasopressin (Human) L312 7.40x39 TM7 polar (hydrogen bond with backbone)
vasopressin (Human) A314 7.42x41 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
Helix box plot — Download: PNG | SVG G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7

GPCRdb(A)
GPCRdb(A)
V2 receptor
TM1
1x28 1.28x28 D33
1x31 1.31x31 L36
1x32 1.32x32 A37
1x35 1.35x35 E40
TM2
2x56 2.57x56 Q92
2x60 2.61x60 Q96
2x64 2.65x64 K100
ECL1
23x49 23.49x49 R104
TM3
3x29 3.29x29 K116
3x32 3.32x32 Q119
3x33 3.33x33 M120
3x36 3.36x36 M123
TM4
4x61 4.60x61 Q174
4x65 4.64x65 F178
ECL2
45x51 45.51x51 W193
45x52 45.52x52 A194
TM5
5x36 5.35x36 R202
5x39 5.38x39 Y205
5x40 5.39x40 V206
5x43 5.42x43 I209
TM6
6x51 6.51x51 F287
6x52 6.52x52 F288
6x55 6.55x55 Q291
6x58 6.58x58 A294
6x59 6.59x59 A295
TM7
7x35 7.36x35 V308
7x38 7.39x38 M311
7x39 7.40x39 L312
7x41 7.42x41 A314