Structure information

V2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7BB6

SPECIES

Homo sapiens

RESOLUTION

4.200

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIADV.ABG5628

PUBLICATION DATE

June 2, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
vasopressin M123 3.36x36 TM3 hydrophobic
vasopressin W193 45.51x51 ECL2 hydrophobic
vasopressin A194 45.52x52 ECL2 polar (hydrogen bond with backbone)
vasopressin A194 45.52x52 ECL2 Van der Waals
vasopressin Q291 6.55x55 TM6 Van der Waals
vasopressin E303 ECL3 Van der Waals
vasopressin F307 7.35x34 TM7 hydrophobic
vasopressin F307 7.35x34 TM7 Van der Waals
vasopressin M311 7.39x38 TM7 polar (hydrogen bond with backbone)
vasopressin M311 7.39x38 TM7 Van der Waals
vasopressin A314 7.42x41 TM7 Van der Waals
vasopressin S315 7.43x42 TM7 polar (hydrogen bond)

Ligands

vasopressin

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Residue Diagrams

G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7
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ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
V2 receptor
TM3
3x36 3.36x36 M123
ECL2
45x51 45.51x51 W193
45x52 45.52x52 A194
TM6
6x55 6.55x55 Q291
TM7
7x34 7.35x34 F307
7x38 7.39x38 M311
7x41 7.42x41 A314
7x42 7.43x42 S315