PDB
7BB6
Resolution
4.2 Å
Released
June 2, 2021
Receptor
V2
Class
A
Species
Homo sapiens
Ligand
Function
vasopressin (Human)
Agonist
Reference
10.1126/SCIADV.ABG5628

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Ligand Amino Acid Generic Number Segment Interaction Type
vasopressin (Human) L36 1.31x31 TM1 hydrophobic
vasopressin (Human) E40 1.35x35 TM1 Van der Waals
vasopressin (Human) I46 1.41x41 TM1 Van der Waals
vasopressin (Human) M123 3.36x36 TM3 hydrophobic
vasopressin (Human) F178 4.64x65 TM4 Van der Waals
vasopressin (Human) W193 45.51x51 ECL2 hydrophobic
vasopressin (Human) A194 45.52x52 ECL2 polar (hydrogen bond with backbone)
vasopressin (Human) A194 45.52x52 ECL2 hydrophobic
vasopressin (Human) V206 5.39x40 TM5 Van der Waals
vasopressin (Human) V290 6.54x54 TM6 hydrophobic
vasopressin (Human) Q291 6.55x55 TM6 Van der Waals
vasopressin (Human) E303 ECL3 polar (charge-charge)
vasopressin (Human) F307 7.35x34 TM7 hydrophobic
vasopressin (Human) M311 7.39x38 TM7 hydrophobic
vasopressin (Human) A314 7.42x41 TM7 hydrophobic
vasopressin (Human) S315 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
Helix box plot — Download: PNG | SVG G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7

GPCRdb(A)
GPCRdb(A)
V2 receptor
TM1
1x31 1.31x31 L36
1x35 1.35x35 E40
1x41 1.41x41 I46
TM3
3x36 3.36x36 M123
TM4
4x65 4.64x65 F178
ECL2
45x51 45.51x51 W193
45x52 45.52x52 A194
TM5
5x40 5.39x40 V206
TM6
6x54 6.54x54 V290
6x55 6.55x55 Q291
TM7
7x34 7.35x34 F307
7x38 7.39x38 M311
7x41 7.42x41 A314
7x42 7.43x42 S315