5-HT5A receptor (5ht5a_mouse)
FAMILY
Class A (Rhodopsin) Aminergic receptors 5-Hydroxytryptamine receptors 5-HT5A receptor
GENE
Htr5a (5ht5a)
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
5-hydroxytryptamine receptor 5A, 5-HT-5, 5-HT-5A, 5-HT5A, Serotonin receptor 5A
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
L
|
P
|
V
|
N
|
L
|
T
|
S
|
F
|
10 |
S
|
L
|
S
|
T
|
P
|
S
|
S
|
L
|
E
|
P
|
20 |
N
|
R
|
S
|
L
|
D
|
T
|
E
|
V
|
L
|
R
|
30 |
TM1 | |||||||||
P
|
S
|
R
|
P
|
F
|
L
|
S
|
A
|
F
|
R
|
40 |
V
|
L
|
V
|
L
|
T
|
L
|
L
|
G
|
F
|
L
|
50 |
A
|
A
|
A
|
T
|
F
|
T
|
W
|
N
|
L
|
L
|
60 |
V
|
L
|
A
|
T
|
I
|
L
|
K
|
V
|
R
|
T
|
70 |
ICL1 | TM2 | ||||||||
F
|
H
|
R
|
V
|
P
|
H
|
N
|
L
|
V
|
A
|
80 |
S
|
M
|
A
|
I
|
S
|
D
|
V
|
L
|
V
|
A
|
90 |
V
|
L
|
V
|
M
|
P
|
L
|
S
|
L
|
V
|
H
|
100 |
ECL1 | |||||||||
E
|
L
|
S
|
G
|
R
|
R
|
W
|
Q
|
L
|
G
|
110 |
TM3 | |||||||||
R
|
R
|
L
|
C
|
Q
|
L
|
W
|
I
|
A
|
C
|
120 |
D
|
V
|
L
|
C
|
C
|
T
|
A
|
S
|
I
|
W
|
130 |
N
|
V
|
T
|
A
|
I
|
A
|
L
|
D
|
R
|
Y
|
140 |
ICL2 | |||||||||
W
|
S
|
I
|
T
|
R
|
H
|
L
|
E
|
Y
|
T
|
150 |
TM4 | |||||||||
L
|
R
|
T
|
R
|
K
|
R
|
V
|
S
|
N
|
V
|
160 |
M
|
I
|
L
|
L
|
T
|
W
|
A
|
L
|
S
|
T
|
170 |
V
|
I
|
S
|
L
|
A
|
P
|
L
|
L
|
F
|
G
|
180 |
ECL2 | |||||||||
W
|
G
|
E
|
T
|
Y
|
S
|
E
|
P
|
S
|
E
|
190 |
TM5 | |||||||||
E
|
C
|
Q
|
V
|
S
|
R
|
E
|
P
|
S
|
Y
|
200 |
T
|
V
|
F
|
S
|
T
|
V
|
G
|
A
|
F
|
Y
|
210 |
L
|
P
|
L
|
C
|
V
|
V
|
L
|
F
|
V
|
Y
|
220 |
W
|
K
|
I
|
Y
|
R
|
A
|
A
|
K
|
F
|
R
|
230 |
M
|
G
|
S
|
R
|
K
|
T
|
N
|
S
|
V
|
S
|
240 |
ICL3 | |||||||||
P
|
V
|
P
|
E
|
A
|
V
|
E
|
V
|
K
|
N
|
250 |
A
|
T
|
Q
|
H
|
P
|
Q
|
M
|
V
|
F
|
T
|
260 |
V
|
R
|
H
|
A
|
T
|
V
|
T
|
F
|
Q
|
T
|
270 |
TM6 | |||||||||
E
|
G
|
D
|
T
|
W
|
R
|
E
|
Q
|
K
|
E
|
280 |
Q
|
R
|
A
|
A
|
L
|
M
|
V
|
G
|
I
|
L
|
290 |
I
|
G
|
V
|
F
|
V
|
L
|
C
|
W
|
F
|
P
|
300 |
F
|
F
|
V
|
T
|
E
|
L
|
I
|
S
|
P
|
L
|
310 |
ECL3 | TM7 | ||||||||
C
|
S
|
W
|
D
|
V
|
P
|
A
|
I
|
W
|
K
|
320 |
S
|
I
|
F
|
L
|
W
|
L
|
G
|
Y
|
S
|
N
|
330 |
S
|
F
|
F
|
N
|
P
|
L
|
I
|
Y
|
T
|
A
|
340 |
H8 | |||||||||
F
|
N
|
R
|
S
|
Y
|
S
|
S
|
A
|
F
|
K
|
350 |
C-term | ||||||||
V
|
F
|
F
|
S
|
K
|
Q
|
Q
|
||
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
5-hydroxytryptamine
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available