chemerin receptor (cml1_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemerin receptor chemerin receptor
GENE
CMKLR1 (CHEMR23, DEZ)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Chemerin-like receptor 1, Chemokine-like receptor 1, G-protein coupled receptor ChemR23, G-protein coupled receptor DEZ
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
R
|
M
|
E
|
D
|
E
|
D
|
Y
|
N
|
T
|
10 |
S
|
I
|
S
|
Y
|
G
|
D
|
E
|
Y
|
P
|
D
|
20 |
Y
|
L
|
D
|
S
|
I
|
V
|
V
|
L
|
E
|
D
|
30 |
TM1 | |||||||||
L
|
S
|
P
|
L
|
E
|
A
|
R
|
V
|
T
|
R
|
40 |
I
|
F
|
L
|
V
|
V
|
V
|
Y
|
S
|
I
|
V
|
50 |
C
|
F
|
L
|
G
|
I
|
L
|
G
|
N
|
G
|
L
|
60 |
V
|
I
|
I
|
I
|
A
|
T
|
F
|
K
|
M
|
K
|
70 |
ICL1 | TM2 | ||||||||
K
|
T
|
V
|
N
|
M
|
V
|
W
|
F
|
L
|
N
|
80 |
L
|
A
|
V
|
A
|
D
|
F
|
L
|
F
|
N
|
V
|
90 |
F
|
L
|
P
|
I
|
H
|
I
|
T
|
Y
|
A
|
A
|
100 |
ECL1 | TM3 | ||||||||
M
|
D
|
Y
|
H
|
W
|
V
|
F
|
G
|
T
|
A
|
110 |
M
|
C
|
K
|
I
|
S
|
N
|
F
|
L
|
L
|
I
|
120 |
H
|
N
|
M
|
F
|
T
|
S
|
V
|
F
|
L
|
L
|
130 |
T
|
I
|
I
|
S
|
S
|
D
|
R
|
C
|
I
|
S
|
140 |
ICL2 | |||||||||
V
|
L
|
L
|
P
|
V
|
W
|
S
|
Q
|
N
|
H
|
150 |
TM4 | |||||||||
R
|
S
|
V
|
R
|
L
|
A
|
Y
|
M
|
A
|
C
|
160 |
M
|
V
|
I
|
W
|
V
|
L
|
A
|
F
|
F
|
L
|
170 |
S
|
S
|
P
|
S
|
L
|
V
|
F
|
R
|
D
|
T
|
180 |
ECL2 | |||||||||
A
|
N
|
L
|
H
|
G
|
K
|
I
|
S
|
C
|
F
|
190 |
N
|
N
|
F
|
S
|
L
|
S
|
T
|
P
|
G
|
S
|
200 |
TM5 | |||||||||
S
|
S
|
W
|
P
|
T
|
H
|
S
|
Q
|
M
|
D
|
210 |
P
|
V
|
G
|
Y
|
S
|
R
|
H
|
M
|
V
|
V
|
220 |
T
|
V
|
T
|
R
|
F
|
L
|
C
|
G
|
F
|
L
|
230 |
V
|
P
|
V
|
L
|
I
|
I
|
T
|
A
|
C
|
Y
|
240 |
L
|
T
|
I
|
V
|
C
|
K
|
L
|
Q
|
R
|
N
|
250 |
ICL3 | TM6 | ||||||||
R
|
L
|
A
|
K
|
T
|
K
|
K
|
P
|
F
|
K
|
260 |
I
|
I
|
V
|
T
|
I
|
I
|
I
|
T
|
F
|
F
|
270 |
L
|
C
|
W
|
C
|
P
|
Y
|
H
|
T
|
L
|
N
|
280 |
ECL3 | |||||||||
L
|
L
|
E
|
L
|
H
|
H
|
T
|
A
|
M
|
P
|
290 |
TM7 | |||||||||
G
|
S
|
V
|
F
|
S
|
L
|
G
|
L
|
P
|
L
|
300 |
A
|
T
|
A
|
L
|
A
|
I
|
A
|
N
|
S
|
C
|
310 |
M
|
N
|
P
|
I
|
L
|
Y
|
V
|
F
|
M
|
G
|
320 |
H8 | |||||||||
Q
|
D
|
F
|
K
|
K
|
F
|
K
|
V
|
A
|
L
|
330 |
C-term | |||||||||
F
|
S
|
R
|
L
|
V
|
N
|
A
|
L
|
S
|
E
|
340 |
D
|
T
|
G
|
H
|
S
|
S
|
Y
|
P
|
S
|
H
|
350 |
R
|
S
|
F
|
T
|
K
|
M
|
S
|
S
|
M
|
N
|
360 |
E
|
R
|
T
|
S
|
M
|
N
|
E
|
R
|
E
|
T
|
370 |
G
|
M
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
EPA, resolvin E1, chemerin, chemerin C-terminal peptide, 18R-HEPE
STRUCTURE MODELS
STRUCTURES
Found 2 structure(s) - view all details on the Structures page