M3 receptor (acm3_rat)
FAMILY
Class A (Rhodopsin) Aminergic receptors Acetylcholine receptors (muscarinic) M3 receptor
GENE
Chrm3 (Chrm-3)
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
Muscarinic acetylcholine receptor M3
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
T
|
L
|
H
|
S
|
N
|
S
|
T
|
T
|
S
|
10 |
P
|
L
|
F
|
P
|
N
|
I
|
S
|
S
|
S
|
W
|
20 |
V
|
H
|
S
|
P
|
S
|
E
|
A
|
G
|
L
|
P
|
30 |
L
|
G
|
T
|
V
|
T
|
Q
|
L
|
G
|
S
|
Y
|
40 |
N
|
I
|
S
|
Q
|
E
|
T
|
G
|
N
|
F
|
S
|
50 |
S
|
N
|
D
|
T
|
S
|
S
|
D
|
P
|
L
|
G
|
60 |
TM1 | |||||||||
G
|
H
|
T
|
I
|
W
|
Q
|
V
|
V
|
F
|
I
|
70 |
A
|
F
|
L
|
T
|
G
|
F
|
L
|
A
|
L
|
V
|
80 |
T
|
I
|
I
|
G
|
N
|
I
|
L
|
V
|
I
|
V
|
90 |
ICL1 | |||||||||
A
|
F
|
K
|
V
|
N
|
K
|
Q
|
L
|
K
|
T
|
100 |
TM2 | |||||||||
V
|
N
|
N
|
Y
|
F
|
L
|
L
|
S
|
L
|
A
|
110 |
C
|
A
|
D
|
L
|
I
|
I
|
G
|
V
|
I
|
S
|
120 |
M
|
N
|
L
|
F
|
T
|
T
|
Y
|
I
|
I
|
M
|
130 |
ECL1 | TM3 | ||||||||
N
|
R
|
W
|
A
|
L
|
G
|
N
|
L
|
A
|
C
|
140 |
D
|
L
|
W
|
L
|
S
|
I
|
D
|
Y
|
V
|
A
|
150 |
S
|
N
|
A
|
S
|
V
|
M
|
N
|
L
|
L
|
V
|
160 |
I
|
S
|
F
|
D
|
R
|
Y
|
F
|
S
|
I
|
T
|
170 |
ICL2 | |||||||||
R
|
P
|
L
|
T
|
Y
|
R
|
A
|
K
|
R
|
T
|
180 |
TM4 | |||||||||
T
|
K
|
R
|
A
|
G
|
V
|
M
|
I
|
G
|
L
|
190 |
A
|
W
|
V
|
I
|
S
|
F
|
V
|
L
|
W
|
A
|
200 |
P
|
A
|
I
|
L
|
F
|
W
|
Q
|
Y
|
F
|
V
|
210 |
ECL2 | |||||||||
G
|
K
|
R
|
T
|
V
|
P
|
P
|
G
|
E
|
C
|
220 |
TM5 | |||||||||
F
|
I
|
Q
|
F
|
L
|
S
|
E
|
P
|
T
|
I
|
230 |
T
|
F
|
G
|
T
|
A
|
I
|
A
|
A
|
F
|
Y
|
240 |
M
|
P
|
V
|
T
|
I
|
M
|
T
|
I
|
L
|
Y
|
250 |
W
|
R
|
I
|
Y
|
K
|
E
|
T
|
E
|
K
|
R
|
260 |
T
|
K
|
E
|
L
|
A
|
G
|
L
|
Q
|
A
|
S
|
270 |
ICL3 | |||||||||
G
|
T
|
E
|
A
|
E
|
A
|
E
|
N
|
F
|
V
|
280 |
H
|
P
|
T
|
G
|
S
|
S
|
R
|
S
|
C
|
S
|
290 |
S
|
Y
|
E
|
L
|
Q
|
Q
|
Q
|
G
|
V
|
K
|
300 |
R
|
S
|
S
|
R
|
R
|
K
|
Y
|
G
|
R
|
C
|
310 |
H
|
F
|
W
|
F
|
T
|
T
|
K
|
S
|
W
|
K
|
320 |
P
|
S
|
A
|
E
|
Q
|
M
|
D
|
Q
|
D
|
H
|
330 |
S
|
S
|
S
|
D
|
S
|
W
|
N
|
N
|
N
|
D
|
340 |
A
|
A
|
A
|
S
|
L
|
E
|
N
|
S
|
A
|
S
|
350 |
S
|
D
|
E
|
E
|
D
|
I
|
G
|
S
|
E
|
T
|
360 |
R
|
A
|
I
|
Y
|
S
|
I
|
V
|
L
|
K
|
L
|
370 |
P
|
G
|
H
|
S
|
S
|
I
|
L
|
N
|
S
|
T
|
380 |
K
|
L
|
P
|
S
|
S
|
D
|
N
|
L
|
Q
|
V
|
390 |
S
|
N
|
E
|
D
|
L
|
G
|
T
|
V
|
D
|
V
|
400 |
E
|
R
|
N
|
A
|
H
|
K
|
L
|
Q
|
A
|
Q
|
410 |
K
|
S
|
M
|
G
|
D
|
G
|
D
|
N
|
C
|
Q
|
420 |
K
|
D
|
F
|
T
|
K
|
L
|
P
|
I
|
Q
|
L
|
430 |
E
|
S
|
A
|
V
|
D
|
T
|
G
|
K
|
T
|
S
|
440 |
D
|
T
|
N
|
S
|
S
|
A
|
D
|
K
|
T
|
T
|
450 |
A
|
T
|
L
|
P
|
L
|
S
|
F
|
K
|
E
|
A
|
460 |
T
|
L
|
A
|
K
|
R
|
F
|
A
|
L
|
K
|
T
|
470 |
R
|
S
|
Q
|
I
|
T
|
K
|
R
|
K
|
R
|
M
|
480 |
TM6 | |||||||||
S
|
L
|
I
|
K
|
E
|
K
|
K
|
A
|
A
|
Q
|
490 |
T
|
L
|
S
|
A
|
I
|
L
|
L
|
A
|
F
|
I
|
500 |
I
|
T
|
W
|
T
|
P
|
Y
|
N
|
I
|
M
|
V
|
510 |
ECL3 | |||||||||
L
|
V
|
N
|
T
|
F
|
C
|
D
|
S
|
C
|
I
|
520 |
TM7 | |||||||||
P
|
K
|
T
|
Y
|
W
|
N
|
L
|
G
|
Y
|
W
|
530 |
L
|
C
|
Y
|
I
|
N
|
S
|
T
|
V
|
N
|
P
|
540 |
H8 | |||||||||
V
|
C
|
Y
|
A
|
L
|
C
|
N
|
K
|
T
|
F
|
550 |
R
|
T
|
T
|
F
|
K
|
T
|
L
|
L
|
L
|
C
|
560 |
C-term | |||||||||
Q
|
C
|
D
|
K
|
R
|
K
|
R
|
R
|
K
|
Q
|
570 |
Q
|
Y
|
Q
|
Q
|
R
|
Q
|
S
|
V
|
I
|
F
|
580 |
H
|
K
|
R
|
V
|
P
|
E
|
Q
|
A
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
acetylcholine
STRUCTURE MODELS
No structure models have been generated as experimental structures are available (see below).