GPR18 (gpr18_human)
FAMILY
Class A (Rhodopsin) Lipid receptors GPR18, GPR55 and GPR119 GPR18
GENE
GPR18 (GPCRW)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
N-arachidonyl glycine receptor, NAGly receptor, G-protein coupled receptor 18
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
I
|
T
|
L
|
N
|
N
|
Q
|
D
|
Q
|
P
|
10 |
TM1 | |||||||||
V
|
P
|
F
|
N
|
S
|
S
|
H
|
P
|
D
|
E
|
20 |
Y
|
K
|
I
|
A
|
A
|
L
|
V
|
F
|
Y
|
S
|
30 |
C
|
I
|
F
|
I
|
I
|
G
|
L
|
F
|
V
|
N
|
40 |
I
|
T
|
A
|
L
|
W
|
V
|
F
|
S
|
C
|
T
|
50 |
ICL1 | TM2 | ||||||||
T
|
K
|
K
|
R
|
T
|
T
|
V
|
T
|
I
|
Y
|
60 |
M
|
M
|
N
|
V
|
A
|
L
|
V
|
D
|
L
|
I
|
70 |
F
|
I
|
M
|
T
|
L
|
P
|
F
|
R
|
M
|
F
|
80 |
ECL1 | |||||||||
Y
|
Y
|
A
|
K
|
D
|
E
|
W
|
P
|
F
|
G
|
90 |
TM3 | |||||||||
E
|
Y
|
F
|
C
|
Q
|
I
|
L
|
G
|
A
|
L
|
100 |
T
|
V
|
F
|
Y
|
P
|
S
|
I
|
A
|
L
|
W
|
110 |
L
|
L
|
A
|
F
|
I
|
S
|
A
|
D
|
R
|
Y
|
120 |
ICL2 | |||||||||
M
|
A
|
I
|
V
|
Q
|
P
|
K
|
Y
|
A
|
K
|
130 |
TM4 | |||||||||
E
|
L
|
K
|
N
|
T
|
C
|
K
|
A
|
V
|
L
|
140 |
A
|
C
|
V
|
G
|
V
|
W
|
I
|
M
|
T
|
L
|
150 |
T
|
T
|
T
|
T
|
P
|
L
|
L
|
L
|
L
|
Y
|
160 |
ECL2 | |||||||||
K
|
D
|
P
|
D
|
K
|
D
|
S
|
T
|
P
|
A
|
170 |
T
|
C
|
L
|
K
|
I
|
S
|
D
|
I
|
I
|
Y
|
180 |
TM5 | |||||||||
L
|
K
|
A
|
V
|
N
|
V
|
L
|
N
|
L
|
T
|
190 |
R
|
L
|
T
|
F
|
F
|
F
|
L
|
I
|
P
|
L
|
200 |
F
|
I
|
M
|
I
|
G
|
C
|
Y
|
L
|
V
|
I
|
210 |
I
|
H
|
N
|
L
|
L
|
H
|
G
|
R
|
T
|
S
|
220 |
TM6 | |||||||||
K
|
L
|
K
|
P
|
K
|
V
|
K
|
E
|
K
|
S
|
230 |
I
|
R
|
I
|
I
|
I
|
T
|
L
|
L
|
V
|
Q
|
240 |
V
|
L
|
V
|
C
|
F
|
M
|
P
|
F
|
H
|
I
|
250 |
C
|
F
|
A
|
F
|
L
|
M
|
L
|
G
|
T
|
G
|
260 |
ECL3 | TM7 | ||||||||
E
|
N
|
S
|
Y
|
N
|
P
|
W
|
G
|
A
|
F
|
270 |
T
|
T
|
F
|
L
|
M
|
N
|
L
|
S
|
T
|
C
|
280 |
L
|
D
|
V
|
I
|
L
|
Y
|
Y
|
I
|
V
|
S
|
290 |
H8 | |||||||||
K
|
Q
|
F
|
Q
|
A
|
R
|
V
|
I
|
S
|
V
|
300 |
C-term | |||||||||
M
|
L
|
Y
|
R
|
N
|
Y
|
L
|
R
|
S
|
M
|
310 |
R
|
R
|
K
|
S
|
F
|
R
|
S
|
G
|
S
|
L
|
320 |
R
|
S
|
L
|
S
|
N
|
I
|
N
|
S
|
E
|
M
|
330 |
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
N-arachidonoylglycine
STRUCTURE MODELS
STRUCTURES
No structures available