GPR18 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

GPR18

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-04-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

κ receptor (sequence similarity: 36%) PDB: 4DJH
Align

TEMPLATES

6RZ6 (CysLT2 receptor)
4DJH (κ receptor)
6B73 (κ receptor)
5XSZ (LPA6 receptor)
6OMM (FPR2/ALX)
3VW7 (PAR1)
5UNG (AT2 receptor)
1U19 (Rhodopsin)
6LFL (CXCR2)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 85.1 7.8 7.1
Side-chains 19.6 56.1 24.3

Number of backbone templates: 9
Number of rotamer templates: 54

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 14 N - - - - -
N-term 15 S - - - - -
N-term 16 S - - - - -
N-term 17 H - - - - -
N-term 18 P - - - - -
TM1 19 D 1.29x29 CysLT2 receptor 6RZ6 CysLT1 receptor 6RZ5
TM1 20 E 1.30x30 κ receptor 4DJH - -
TM1 21 Y 1.31x31 κ receptor 4DJH OX2 receptor 5WQC
TM1 22 K 1.32x32 κ receptor 4DJH CXCR2 6LFL
TM1 23 I 1.33x33 κ receptor 4DJH μ receptor 4DKL
TM1 24 A 1.34x34 κ receptor 4DJH δ receptor 4N6H
TM1 25 A 1.35x35 κ receptor 4DJH DP2 receptor 6D27
TM1 26 L 1.36x36 κ receptor 4DJH C5a1 receptor 6C1Q
TM1 27 V 1.37x37 κ receptor 4DJH ETB receptor 5X93
TM1 28 F 1.38x38 κ receptor 4DJH succinate receptor 6RNK
TM1 29 Y 1.39x39 κ receptor 4DJH κ receptor 4DJH
TM1 30 S 1.40x40 κ receptor 4DJH κ receptor 4DJH
TM1 31 C 1.41x41 κ receptor 4DJH - -
TM1 32 I 1.42x42 κ receptor 4DJH CCR7 6QZH
TM1 33 F 1.43x43 κ receptor 4DJH κ receptor 4DJH
TM1 34 I 1.44x44 κ receptor 4DJH CCR5 4MBS
TM1 35 I 1.45x45 κ receptor 4DJH M5 receptor 6OL9
TM1 36 G 1.46x46 κ receptor 4DJH κ receptor 4DJH
TM1 37 L 1.47x47 κ receptor 4DJH κ receptor 4DJH
TM1 38 F 1.48x48 κ receptor 4DJH AT1 receptor 4ZUD
TM1 39 V 1.49x49 κ receptor 4DJH AT2 receptor 5UNG
TM1 40 N 1.50x50 κ receptor 4DJH κ receptor 4DJH
TM1 41 I 1.51x51 κ receptor 4DJH 5-HT2C receptor 6BQH
TM1 42 T 1.52x52 κ receptor 4DJH ETB receptor 5X93
TM1 43 A 1.53x53 κ receptor 4DJH EP4 receptor 5YWY
TM1 44 L 1.54x54 κ receptor 4DJH apelin receptor 5VBL
TM1 45 W 1.55x55 κ receptor 4DJH apelin receptor 5VBL
TM1 46 V 1.56x56 κ receptor 4DJH κ receptor 4DJH
TM1 47 F 1.57x57 κ receptor 4DJH M3 receptor 5ZHP
TM1 48 S 1.58x58 κ receptor 4DJH ghrelin receptor 6KO5
TM1 49 C 1.59x59 κ receptor 4DJH DP2 receptor 6D27
TM1 50 T 1.60x60 κ receptor 4DJH 5-HT1B receptor 4IAQ
ICL1 51 T - κ receptor 4DJH - -
ICL1 52 K - κ receptor 4DJH - -
ICL1 53 K - κ receptor 4DJH - -
ICL1 54 R - κ receptor 4DJH - -
TM2 55 T 2.37x37 κ receptor 4DJH κ receptor 4DJH
TM2 56 T 2.38x38 κ receptor 4DJH ghrelin receptor 6KO5
TM2 57 V 2.39x39 κ receptor 4DJH DP2 receptor 6D27
TM2 58 T 2.40x40 κ receptor 4DJH DP2 receptor 6D27
TM2 59 I 2.41x41 κ receptor 4DJH κ receptor 4DJH
TM2 60 Y 2.42x42 κ receptor 4DJH κ receptor 4DJH
TM2 61 M 2.43x43 κ receptor 4DJH OT receptor 6TPK
TM2 62 M 2.44x44 κ receptor 4DJH 5-HT2C receptor 6BQH
TM2 63 N 2.45x45 κ receptor 4DJH κ receptor 4DJH
TM2 64 V 2.46x46 κ receptor 4DJH - -
TM2 65 A 2.47x47 κ receptor 4DJH κ receptor 4DJH
TM2 66 L 2.48x48 κ receptor 4DJH κ receptor 4DJH
TM2 67 V 2.49x49 κ receptor 4DJH - -
TM2 68 D 2.50x50 κ receptor 4DJH κ receptor 4DJH
TM2 69 L 2.51x51 κ receptor 4DJH CXCR2 6LFL
TM2 70 I 2.52x52 κ receptor 4DJH H1 receptor 3RZE
TM2 71 F 2.53x53 κ receptor 4DJH CXCR2 6LFL
TM2 72 I 2.54x54 κ receptor 4DJH ETB receptor 5X93
TM2 73 M 2.55x55 κ receptor 4DJH - -
TM2 74 T 2.56x56 κ receptor 4DJH κ receptor 4DJH
TM2 75 L 2.57x57 κ receptor 4DJH CXCR2 6LFL
TM2 76 P 2.58x58 κ receptor 4DJH κ receptor 4DJH
TM2 77 F 2.59x59 κ receptor 4DJH κ receptor 4DJH
TM2 78 R 2.60x60 κ receptor 4DJH LPA6 receptor 5XSZ
TM2 79 M 2.61x61 κ receptor 4DJH 5-HT2A receptor 6A94
TM2 80 F 2.62x62 κ receptor 4DJH NK1 receptor 6HLP
TM2 81 Y 2.63x63 κ receptor 4DJH AT1 receptor 4ZUD
TM2 82 Y 2.64x64 κ receptor 4DJH κ receptor 4DJH
TM2 83 A 2.65x65 κ receptor 4DJH CCR7 6QZH
TM2 84 K 2.66x66 κ receptor 4DJH CCR7 6QZH
ECL1 85 D - - - - -
ECL1 86 E 23.49x49 κ receptor 4DJH CCR2 5T1A
ECL1 87 W 23.50x50 κ receptor 4DJH κ receptor 4DJH
ECL1 88 P 23.51x51 κ receptor 4DJH κ receptor 4DJH
ECL1 89 F 23.52x52 κ receptor 4DJH κ receptor 4DJH
TM3 90 G 3.21x21 κ receptor 4DJH κ receptor 4DJH
TM3 91 E 3.22x22 κ receptor 4DJH δ receptor 4N6H
TM3 92 Y 3.23x23 κ receptor 4DJH AT1 receptor 4ZUD
TM3 93 F 3.24x24 κ receptor 4DJH CCR7 6QZH
TM3 94 C 3.25x25 κ receptor 4DJH κ receptor 4DJH
TM3 95 Q 3.26x26 κ receptor 4DJH CCR5 4MBS
TM3 96 I 3.27x27 κ receptor 4DJH κ receptor 4DJH
TM3 97 L 3.28x28 κ receptor 4DJH CCR5 4MBS
TM3 98 G 3.29x29 κ receptor 4DJH Rhodopsin 1U19
TM3 99 A 3.30x30 κ receptor 4DJH CCR7 6QZH
TM3 100 L 3.31x31 κ receptor 4DJH CXCR2 6LFL
TM3 101 T 3.32x32 κ receptor 4DJH - -
TM3 102 V 3.33x33 κ receptor 4DJH 5-HT2C receptor 6BQH
TM3 103 F 3.34x34 κ receptor 4DJH AT1 receptor 4ZUD
TM3 104 Y 3.35x35 κ receptor 4DJH - -
TM3 105 P 3.36x36 κ receptor 4DJH - -
TM3 106 S 3.37x37 κ receptor 4DJH OX2 receptor 5WQC
TM3 107 I 3.38x38 κ receptor 4DJH ETB receptor 5X93
TM3 108 A 3.39x39 κ receptor 4DJH Rhodopsin 1U19
TM3 109 L 3.40x40 κ receptor 4DJH Rhodopsin 1U19
TM3 110 W 3.41x41 κ receptor 4DJH CXCR2 6LFL
TM3 111 L 3.42x42 κ receptor 4DJH CXCR2 6LFL
TM3 112 L 3.43x43 κ receptor 4DJH κ receptor 4DJH
TM3 113 A 3.44x44 κ receptor 4DJH CXCR2 6LFL
TM3 114 F 3.45x45 κ receptor 4DJH CXCR4 3ODU
TM3 115 I 3.46x46 κ receptor 4DJH CXCR2 6LFL
TM3 116 S 3.47x47 κ receptor 4DJH κ receptor 4DJH
TM3 117 A 3.48x48 κ receptor 4DJH C5a1 receptor 6C1Q
TM3 118 D 3.49x49 κ receptor 4DJH κ receptor 4DJH
TM3 119 R 3.50x50 κ receptor 4DJH κ receptor 4DJH
TM3 120 Y 3.51x51 κ receptor 4DJH κ receptor 4DJH
TM3 121 M 3.52x52 κ receptor 4DJH NK1 receptor 6HLP
TM3 122 A 3.53x53 κ receptor 4DJH κ receptor 4DJH
TM3 123 I 3.54x54 κ receptor 4DJH CXCR2 6LFL
TM3 124 V 3.55x55 κ receptor 4DJH CXCR2 6LFL
TM3 125 Q 3.56x56 κ receptor 4DJH CCR9 5LWE
ICL2 126 P 34.50x50 - - - -
ICL2 127 K 34.51x51 κ receptor 6B73 - -
ICL2 128 Y 34.52x52 κ receptor 6B73 - -
ICL2 129 A 34.53x53 κ receptor 6B73 κ receptor 6B73
ICL2 130 K 34.54x54 κ receptor 6B73 ghrelin receptor 6KO5
ICL2 131 E 34.55x55 κ receptor 6B73 - -
ICL2 132 L 34.56x56 κ receptor 6B73 BLT1 receptor 7K15
ICL2 133 K 34.57x57 - - - -
TM4 134 N 4.38x38 κ receptor 4DJH S1P1 receptor 3V2Y
TM4 135 T 4.39x39 κ receptor 4DJH M3 receptor 5ZHP
TM4 136 C 4.40x40 κ receptor 4DJH FFA1 receptor 5TZY
TM4 137 K 4.41x41 κ receptor 4DJH κ receptor 4DJH
TM4 138 A 4.42x42 κ receptor 4DJH κ receptor 4DJH
TM4 139 V 4.43x43 κ receptor 4DJH CCR5 4MBS
TM4 140 L 4.44x44 κ receptor 4DJH CCR7 6QZH
TM4 141 A 4.45x45 κ receptor 4DJH apelin receptor 5VBL
TM4 142 C 4.46x46 κ receptor 4DJH CXCR2 6LFL
TM4 143 V 4.47x47 κ receptor 4DJH CCR7 6QZH
TM4 144 G 4.48x48 κ receptor 4DJH CCR7 6QZH
TM4 145 V 4.49x49 κ receptor 4DJH CXCR4 3ODU
TM4 146 W 4.50x50 κ receptor 4DJH κ receptor 4DJH
TM4 147 I 4.51x51 κ receptor 4DJH CCR7 6QZH
TM4 148 M 4.52x52 κ receptor 4DJH Rhodopsin 1U19
TM4 149 T 4.53x53 κ receptor 4DJH MT1 receptor 6ME2
TM4 150 L 4.54x54 κ receptor 4DJH CXCR2 6LFL
TM4 151 T 4.55x55 κ receptor 4DJH D2 receptor 6LUQ
TM4 152 T 4.56x56 κ receptor 4DJH β2-adrenoceptor 2RH1
TM4 153 T 4.57x57 CysLT2 receptor 6RZ6 DP2 receptor 6D27
TM4 154 T 4.58x59 CysLT2 receptor 6RZ6 BLT1 receptor 7K15
TM4 155 P 4.59x60 κ receptor 4DJH CXCR2 6LFL
TM4 156 L 4.60x61 κ receptor 4DJH D2 receptor 6LUQ
TM4 157 L 4.61x62 κ receptor 4DJH CXCR2 6LFL
TM4 158 L 4.62x63 κ receptor 4DJH κ receptor 4DJH
TM4 159 L 4.63x64 κ receptor 4DJH - -
TM4 160 Y 4.64x65 LPA6 receptor 5XSZ - -
ECL2 161 K - κ receptor 4DJH - -
ECL2 162 D - κ receptor 4DJH - -
ECL2 163 P - κ receptor 4DJH - -
ECL2 164 D - κ receptor 4DJH - -
ECL2 165 K - κ receptor 4DJH - -
ECL2 166 D - κ receptor 4DJH - -
ECL2 167 S - κ receptor 4DJH - -
ECL2 168 T - κ receptor 4DJH - -
ECL2 169 P - κ receptor 4DJH - -
ECL2 170 A - κ receptor 4DJH - -
ECL2 171 T - κ receptor 4DJH - -
ECL2 172 C 45.50x50 κ receptor 4DJH κ receptor 4DJH
ECL2 173 L 45.51x51 κ receptor 4DJH NOP receptor 5DHG
ECL2 174 K 45.52x52 κ receptor 4DJH - -
ECL2 175 I - - - - -
ECL2 176 S - - - - -
ECL2 177 D - - - - -
ECL2 178 I - - - - -
TM5 179 I 5.30x30 FPR2/ALX 6OMM - -
TM5 180 Y 5.31x31 κ receptor 4DJH - -
TM5 181 L 5.32x32 κ receptor 4DJH PAR2 5NDD
TM5 182 K 5.33x33 κ receptor 4DJH C5a1 receptor 6C1Q
TM5 183 A 5.34x34 κ receptor 4DJH apelin receptor 5VBL
TM5 184 V 5.35x35 κ receptor 4DJH - -
TM5 185 N 5.36x36 κ receptor 4DJH CCR2 5T1A
TM5 186 V 5.37x37 κ receptor 4DJH apelin receptor 5VBL
TM5 187 L 5.38x38 κ receptor 4DJH CXCR2 6LFL
TM5 188 N 5.39x39 κ receptor 4DJH - -
TM5 189 L 5.40x40 κ receptor 4DJH BLT1 receptor 7K15
TM5 190 T 5.41x41 κ receptor 4DJH Y1 receptor 5ZBH
TM5 191 R 5.42x42 κ receptor 4DJH - -
TM5 192 L 5.43x43 κ receptor 4DJH ETB receptor 5X93
TM5 193 T 5.44x44 κ receptor 4DJH apelin receptor 5VBL
TM5 194 F 5.45x45 κ receptor 4DJH NTS1 receptor 4BUO
TM5 195 F 5.46x46 PAR1 3VW7 PAR1 3VW7
TM5 196 F 5.47x47 PAR1 3VW7 PAR1 3VW7
TM5 197 L 5.48x48 κ receptor 4DJH CCR7 6QZH
TM5 198 I 5.49x49 κ receptor 4DJH κ receptor 4DJH
TM5 199 P 5.50x50 κ receptor 4DJH κ receptor 4DJH
TM5 200 L 5.51x51 κ receptor 4DJH CXCR2 6LFL
TM5 201 F 5.52x52 κ receptor 4DJH ghrelin receptor 6KO5
TM5 202 I 5.53x53 κ receptor 4DJH κ receptor 4DJH
TM5 203 M 5.54x54 κ receptor 4DJH CXCR2 6LFL
TM5 204 I 5.55x55 κ receptor 4DJH κ receptor 4DJH
TM5 205 G 5.56x56 κ receptor 4DJH A2A receptor 5IU4
TM5 206 C 5.57x57 κ receptor 4DJH κ receptor 4DJH
TM5 207 Y 5.58x58 κ receptor 4DJH κ receptor 4DJH
TM5 208 L 5.59x59 κ receptor 4DJH CCR7 6QZH
TM5 209 V 5.60x60 κ receptor 4DJH CCR7 6QZH
TM5 210 I 5.61x61 κ receptor 4DJH CCR7 6QZH
TM5 211 I 5.62x62 κ receptor 4DJH κ receptor 4DJH
TM5 212 H 5.63x63 κ receptor 4DJH 5-HT2B receptor 5TVN
TM5 213 N 5.64x64 κ receptor 4DJH - -
TM5 214 L 5.65x65 κ receptor 4DJH κ receptor 4DJH
TM5 215 L 5.66x66 κ receptor 4DJH CCR5 4MBS
TM5 216 H 5.67x67 κ receptor 4DJH DP2 receptor 6D27
TM5 217 G 5.68x68 κ receptor 4DJH - -
ICL3 218 R - - - - -
ICL3 219 T - AT2 receptor 5UNG - -
ICL3 220 S - - - - -
TM6 221 K 6.24x24 κ receptor 6B73 δ receptor 4RWD
TM6 222 L 6.25x25 κ receptor 6B73 D2 receptor 6VMS
TM6 223 K 6.26x26 κ receptor 6B73 κ receptor 6VI4
TM6 224 P 6.27x27 κ receptor 6B73 - -
TM6 225 K 6.28x28 κ receptor 4DJH CCR5 5UIW
TM6 226 V 6.29x29 κ receptor 4DJH - -
TM6 227 K 6.30x30 κ receptor 4DJH CXCR2 6LFL
TM6 228 E 6.31x31 κ receptor 4DJH TP receptor 6IIV
TM6 229 K 6.32x32 κ receptor 4DJH CCR2 5T1A
TM6 230 S 6.33x33 κ receptor 4DJH - -
TM6 231 I 6.34x34 κ receptor 4DJH CCR6 6WWZ
TM6 232 R 6.35x35 κ receptor 4DJH κ receptor 4DJH
TM6 233 I 6.36x36 κ receptor 4DJH AT1 receptor 4ZUD
TM6 234 I 6.37x37 κ receptor 4DJH CXCR2 6LFL
TM6 235 I 6.38x38 κ receptor 4DJH CCR7 6QZH
TM6 236 T 6.39x39 κ receptor 4DJH CCR5 4MBS
TM6 237 L 6.40x40 κ receptor 4DJH apelin receptor 5VBL
TM6 238 L 6.41x41 κ receptor 4DJH OX2 receptor 5WQC
TM6 239 V 6.42x42 κ receptor 4DJH CCR7 6QZH
TM6 240 Q 6.43x43 κ receptor 4DJH - -
TM6 241 V 6.44x44 κ receptor 4DJH EP4 receptor 5YWY
TM6 242 L 6.45x45 κ receptor 4DJH CXCR2 6LFL
TM6 243 V 6.46x46 κ receptor 4DJH κ receptor 4DJH
TM6 244 C 6.47x47 κ receptor 4DJH κ receptor 4DJH
TM6 245 F 6.48x48 κ receptor 4DJH MT1 receptor 6ME2
TM6 246 M 6.49x49 κ receptor 4DJH apelin receptor 5VBL
TM6 247 P 6.50x50 κ receptor 4DJH κ receptor 4DJH
TM6 248 F 6.51x51 κ receptor 4DJH ghrelin receptor 6KO5
TM6 249 H 6.52x52 κ receptor 4DJH κ receptor 4DJH
TM6 250 I 6.53x53 κ receptor 4DJH κ receptor 4DJH
TM6 251 C 6.54x54 κ receptor 4DJH - -
TM6 252 F 6.55x55 κ receptor 4DJH H1 receptor 3RZE
TM6 253 A 6.56x56 κ receptor 4DJH CB2 receptor 5ZTY
TM6 254 F 6.57x57 κ receptor 4DJH A2A receptor 5IU4
TM6 255 L 6.58x58 κ receptor 4DJH 5-HT2B receptor 5TVN
TM6 256 M 6.59x59 κ receptor 4DJH apelin receptor 5VBL
TM6 257 L 6.60x60 κ receptor 4DJH κ receptor 4DJH
TM6 258 G 6.61x61 κ receptor 4DJH κ receptor 4DJH
ECL3 259 T - - - - -
ECL3 260 G - Rhodopsin 1U19 Rhodopsin 1U19
ECL3 261 E - Rhodopsin 1U19 - -
ECL3 262 N - Rhodopsin 1U19 - -
ECL3 263 S - - - - -
TM7 264 Y 7.31x30 κ receptor 4DJH NTS1 receptor 4BUO
TM7 265 N 7.32x31 κ receptor 4DJH CCR7 6QZH
TM7 266 P 7.33x32 κ receptor 4DJH α2C-adrenoceptor 6KUW
TM7 267 W 7.34x33 κ receptor 4DJH CXCR4 3ODU
TM7 268 G 7.35x34 κ receptor 4DJH - -
TM7 269 A 7.36x35 κ receptor 4DJH OX2 receptor 6TPN
TM7 270 F 7.37x36 κ receptor 4DJH κ receptor 4DJH
TM7 271 T 7.38x37 κ receptor 4DJH CXCR2 6LFL
TM7 272 T 7.39x38 κ receptor 4DJH apelin receptor 5VBL
TM7 273 F 7.40x39 κ receptor 4DJH Rhodopsin 1U19
TM7 274 L 7.41x40 κ receptor 4DJH κ receptor 4DJH
TM7 275 M 7.42x41 κ receptor 4DJH - -
TM7 276 N 7.43x42 κ receptor 4DJH - -
TM7 277 L 7.44x43 κ receptor 4DJH CXCR2 6LFL
TM7 278 S 7.45x45 κ receptor 4DJH ghrelin receptor 6KO5
TM7 279 T 7.46x46 κ receptor 4DJH Y1 receptor 5ZBH
TM7 280 C 7.47x47 κ receptor 4DJH CXCR2 6LFL
TM7 281 L 7.48x48 κ receptor 4DJH κ receptor 4DJH
TM7 282 D 7.49x49 κ receptor 4DJH EP4 receptor 5YWY
TM7 283 V 7.50x50 κ receptor 4DJH - -
TM7 284 I 7.51x51 κ receptor 4DJH κ receptor 4DJH
TM7 285 L 7.52x52 κ receptor 4DJH κ receptor 4DJH
TM7 286 Y 7.53x53 κ receptor 4DJH κ receptor 4DJH
TM7 287 Y 7.54x54 κ receptor 4DJH ETB receptor 5X93
TM7 288 I 7.55x55 κ receptor 4DJH ghrelin receptor 6KO5
TM7 289 V 7.56x56 κ receptor 4DJH CCR5 4MBS
H8 290 S 8.47x47 κ receptor 4DJH ghrelin receptor 6KO5
H8 291 K 8.48x48 κ receptor 4DJH ghrelin receptor 6KO5
H8 292 Q 8.49x49 κ receptor 4DJH Rhodopsin 1U19
H8 293 F 8.50x50 κ receptor 4DJH κ receptor 4DJH
H8 294 Q 8.51x51 κ receptor 4DJH Y1 receptor 5ZBH
H8 295 A 8.52x52 κ receptor 4DJH NOP receptor 5DHG
H8 296 R 8.53x53 κ receptor 4DJH CysLT2 receptor 6RZ6
H8 297 V 8.54x54 κ receptor 4DJH ghrelin receptor 6KO5
H8 298 I 8.55x55 κ receptor 4DJH EP4 receptor 5YWY
H8 299 S 8.56x56 κ receptor 4DJH apelin receptor 5VBL
H8 300 V 8.57x57 κ receptor 4DJH AT2 receptor 5UNG
H8 301 M 8.58x58 κ receptor 4DJH - -
H8 302 L 8.59x59 κ receptor 4DJH M5 receptor 6OL9
H8 303 Y 8.60x60 CXCR2 6LFL - -
H8 304 R 8.61x61 CXCR2 6LFL - -
C-term 305 N - - - - -
C-term 306 Y - - - - -
C-term 307 L - - - - -
C-term 308 R - - - - -
C-term 309 S - - - - -