V1B receptor (v1br_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Vasopressin and oxytocin receptors V1B receptor
GENE
AVPR1B (AVPR3, VPR3)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Vasopressin V1b receptor, V1bR, AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, Vasopressin V3 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
S
|
G
|
P
|
L
|
W
|
D
|
A
|
N
|
10 |
P
|
T
|
P
|
R
|
G
|
T
|
L
|
S
|
A
|
P
|
20 |
N
|
A
|
T
|
T
|
P
|
W
|
L
|
G
|
R
|
D
|
30 |
TM1 | |||||||||
E
|
E
|
L
|
A
|
K
|
V
|
E
|
I
|
G
|
V
|
40 |
L
|
A
|
T
|
V
|
L
|
V
|
L
|
A
|
T
|
G
|
50 |
G
|
N
|
L
|
A
|
V
|
L
|
L
|
T
|
L
|
G
|
60 |
ICL1 | TM2 | ||||||||
Q
|
L
|
G
|
R
|
K
|
R
|
S
|
R
|
M
|
H
|
70 |
L
|
F
|
V
|
L
|
H
|
L
|
A
|
L
|
T
|
D
|
80 |
L
|
A
|
V
|
A
|
L
|
F
|
Q
|
V
|
L
|
P
|
90 |
Q
|
L
|
L
|
W
|
D
|
I
|
T
|
Y
|
R
|
F
|
100 |
ECL1 | TM3 | ||||||||
Q
|
G
|
P
|
D
|
L
|
L
|
C
|
R
|
A
|
V
|
110 |
K
|
Y
|
L
|
Q
|
V
|
L
|
S
|
M
|
F
|
A
|
120 |
S
|
T
|
Y
|
M
|
L
|
L
|
A
|
M
|
T
|
L
|
130 |
D
|
R
|
Y
|
L
|
A
|
V
|
C
|
H
|
P
|
L
|
140 |
ICL2 | TM4 | ||||||||
R
|
S
|
L
|
Q
|
Q
|
P
|
G
|
Q
|
S
|
T
|
150 |
Y
|
L
|
L
|
I
|
A
|
A
|
P
|
W
|
L
|
L
|
160 |
A
|
A
|
I
|
F
|
S
|
L
|
P
|
Q
|
V
|
F
|
170 |
ECL2 | |||||||||
I
|
F
|
S
|
L
|
R
|
E
|
V
|
I
|
Q
|
G
|
180 |
S
|
G
|
V
|
L
|
D
|
C
|
W
|
A
|
D
|
F
|
190 |
TM5 | |||||||||
G
|
F
|
P
|
W
|
G
|
P
|
R
|
A
|
Y
|
L
|
200 |
T
|
W
|
T
|
T
|
L
|
A
|
I
|
F
|
V
|
L
|
210 |
P
|
V
|
T
|
M
|
L
|
T
|
A
|
C
|
Y
|
S
|
220 |
L
|
I
|
C
|
H
|
E
|
I
|
C
|
K
|
N
|
L
|
230 |
K
|
V
|
K
|
T
|
Q
|
A
|
W
|
R
|
V
|
G
|
240 |
ICL3 | |||||||||
G
|
G
|
G
|
W
|
R
|
T
|
W
|
D
|
R
|
P
|
250 |
S
|
P
|
S
|
T
|
L
|
A
|
A
|
T
|
T
|
R
|
260 |
G
|
L
|
P
|
S
|
R
|
V
|
S
|
S
|
I
|
N
|
270 |
TM6 | |||||||||
T
|
I
|
S
|
R
|
A
|
K
|
I
|
R
|
T
|
V
|
280 |
K
|
M
|
T
|
F
|
V
|
I
|
V
|
L
|
A
|
Y
|
290 |
I
|
A
|
C
|
W
|
A
|
P
|
F
|
F
|
S
|
V
|
300 |
Q
|
M
|
W
|
S
|
V
|
W
|
D
|
K
|
N
|
A
|
310 |
ECL3 | TM7 | ||||||||
P
|
D
|
E
|
D
|
S
|
T
|
N
|
V
|
A
|
F
|
320 |
T
|
I
|
S
|
M
|
L
|
L
|
G
|
N
|
L
|
N
|
330 |
S
|
C
|
C
|
N
|
P
|
W
|
I
|
Y
|
M
|
G
|
340 |
H8 | |||||||||
F
|
N
|
S
|
H
|
L
|
L
|
P
|
R
|
P
|
L
|
350 |
R
|
H
|
L
|
A
|
C
|
C
|
G
|
G
|
P
|
Q
|
360 |
C-term | |||||||||
P
|
R
|
M
|
R
|
R
|
R
|
L
|
S
|
D
|
G
|
370 |
S
|
L
|
S
|
S
|
R
|
H
|
T
|
T
|
L
|
L
|
380 |
T
|
R
|
S
|
S
|
C
|
P
|
A
|
T
|
L
|
S
|
390 |
L
|
S
|
L
|
S
|
L
|
T
|
L
|
S
|
G
|
R
|
400 |
P
|
R
|
P
|
E
|
E
|
S
|
P
|
R
|
D
|
L
|
410 |
E
|
L
|
A
|
D
|
G
|
E
|
G
|
T
|
A
|
E
|
420 |
T
|
I
|
I
|
F
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
oxytocin, vasopressin
STRUCTURE MODELS
STRUCTURES
No structures available