Y1 receptor (npy1r_rat)
FAMILY
Class A (Rhodopsin) Peptide receptors Neuropeptide Y receptors Y1 receptor
GENE
Npy1r
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
Neuropeptide Y receptor type 1, NPY1-R, FC5
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
S
|
T
|
L
|
F
|
S
|
R
|
V
|
E
|
10 |
N
|
Y
|
S
|
V
|
H
|
Y
|
N
|
V
|
S
|
E
|
20 |
N
|
S
|
P
|
F
|
L
|
A
|
F
|
E
|
N
|
D
|
30 |
TM1 | |||||||||
D
|
C
|
H
|
L
|
P
|
L
|
A
|
V
|
I
|
F
|
40 |
T
|
L
|
A
|
L
|
A
|
Y
|
G
|
A
|
V
|
I
|
50 |
I
|
L
|
G
|
V
|
S
|
G
|
N
|
L
|
A
|
L
|
60 |
I
|
I
|
I
|
I
|
L
|
K
|
Q
|
K
|
E
|
M
|
70 |
ICL1 | TM2 | ||||||||
R
|
N
|
V
|
T
|
N
|
I
|
L
|
I
|
V
|
N
|
80 |
L
|
S
|
F
|
S
|
D
|
L
|
L
|
V
|
A
|
V
|
90 |
M
|
C
|
L
|
P
|
F
|
T
|
F
|
V
|
Y
|
T
|
100 |
ECL1 | TM3 | ||||||||
L
|
M
|
D
|
H
|
W
|
V
|
F
|
G
|
E
|
T
|
110 |
M
|
C
|
K
|
L
|
N
|
P
|
F
|
V
|
Q
|
C
|
120 |
V
|
S
|
I
|
T
|
V
|
S
|
I
|
F
|
S
|
L
|
130 |
V
|
L
|
I
|
A
|
V
|
E
|
R
|
H
|
Q
|
L
|
140 |
ICL2 | |||||||||
I
|
I
|
N
|
P
|
R
|
G
|
W
|
R
|
P
|
N
|
150 |
TM4 | |||||||||
N
|
R
|
H
|
A
|
Y
|
I
|
G
|
I
|
T
|
V
|
160 |
I
|
W
|
V
|
L
|
A
|
V
|
A
|
S
|
S
|
L
|
170 |
ECL2 | |||||||||
P
|
F
|
V
|
I
|
Y
|
Q
|
I
|
L
|
T
|
D
|
180 |
E
|
P
|
F
|
Q
|
N
|
V
|
S
|
L
|
A
|
A
|
190 |
F
|
K
|
D
|
K
|
Y
|
V
|
C
|
F
|
D
|
K
|
200 |
TM5 | |||||||||
F
|
P
|
S
|
D
|
S
|
H
|
R
|
L
|
S
|
Y
|
210 |
T
|
T
|
L
|
L
|
L
|
V
|
L
|
Q
|
Y
|
F
|
220 |
G
|
P
|
L
|
C
|
F
|
I
|
F
|
I
|
C
|
Y
|
230 |
F
|
K
|
I
|
Y
|
I
|
R
|
L
|
K
|
R
|
R
|
240 |
ICL3 | |||||||||
N
|
N
|
M
|
M
|
D
|
K
|
I
|
R
|
D
|
S
|
250 |
TM6 | |||||||||
K
|
Y
|
R
|
S
|
S
|
E
|
T
|
K
|
R
|
I
|
260 |
N
|
V
|
M
|
L
|
L
|
S
|
I
|
V
|
V
|
A
|
270 |
F
|
A
|
V
|
C
|
W
|
L
|
P
|
L
|
T
|
I
|
280 |
F
|
N
|
T
|
V
|
F
|
D
|
W
|
N
|
H
|
Q
|
290 |
ECL3 | TM7 | ||||||||
I
|
I
|
A
|
T
|
C
|
N
|
H
|
N
|
L
|
L
|
300 |
F
|
L
|
L
|
C
|
H
|
L
|
T
|
A
|
M
|
I
|
310 |
S
|
T
|
C
|
V
|
N
|
P
|
I
|
F
|
Y
|
G
|
320 |
H8 | |||||||||
F
|
L
|
N
|
K
|
N
|
F
|
Q
|
R
|
D
|
L
|
330 |
C-term | |||||||||
Q
|
F
|
F
|
F
|
N
|
F
|
C
|
D
|
F
|
R
|
340 |
S
|
R
|
D
|
D
|
D
|
Y
|
E
|
T
|
I
|
A
|
350 |
M
|
S
|
T
|
M
|
H
|
T
|
D
|
V
|
S
|
K
|
360 |
T
|
S
|
L
|
K
|
Q
|
A
|
S
|
P
|
V
|
A
|
370 |
F
|
K
|
K
|
I
|
S
|
M
|
N
|
D
|
N
|
E
|
380 |
K
|
I
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
peptide YY, pancreatic polypeptide, neuropeptide Y
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available