5-HT2B receptor (5ht2b_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors 5-Hydroxytryptamine receptors 5-HT2B receptor
GENE
HTR2B
ORGANISM
Human (Homo sapiens)
ALT. NAMES
5-hydroxytryptamine receptor 2B, 5-HT-2B, 5-HT2B, Serotonin receptor 2B
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
L
|
S
|
Y
|
R
|
V
|
S
|
E
|
L
|
10 |
Q
|
S
|
T
|
I
|
P
|
E
|
H
|
I
|
L
|
Q
|
20 |
S
|
T
|
F
|
V
|
H
|
V
|
I
|
S
|
S
|
N
|
30 |
W
|
S
|
G
|
L
|
Q
|
T
|
E
|
S
|
I
|
P
|
40 |
E
|
E
|
M
|
K
|
Q
|
I
|
V
|
E
|
E
|
Q
|
50 |
TM1 | |||||||||
G
|
N
|
K
|
L
|
H
|
W
|
A
|
A
|
L
|
L
|
60 |
I
|
L
|
M
|
V
|
I
|
I
|
P
|
T
|
I
|
G
|
70 |
G
|
N
|
T
|
L
|
V
|
I
|
L
|
A
|
V
|
S
|
80 |
ICL1 | TM2 | ||||||||
L
|
E
|
K
|
K
|
L
|
Q
|
Y
|
A
|
T
|
N
|
90 |
Y
|
F
|
L
|
M
|
S
|
L
|
A
|
V
|
A
|
D
|
100 |
L
|
L
|
V
|
G
|
L
|
F
|
V
|
M
|
P
|
I
|
110 |
A
|
L
|
L
|
T
|
I
|
M
|
F
|
E
|
A
|
M
|
120 |
ECL1 | TM3 | ||||||||
W
|
P
|
L
|
P
|
L
|
V
|
L
|
C
|
P
|
A
|
130 |
W
|
L
|
F
|
L
|
D
|
V
|
L
|
F
|
S
|
T
|
140 |
A
|
S
|
I
|
M
|
H
|
L
|
C
|
A
|
I
|
S
|
150 |
V
|
D
|
R
|
Y
|
I
|
A
|
I
|
K
|
K
|
P
|
160 |
ICL2 | TM4 | ||||||||
I
|
Q
|
A
|
N
|
Q
|
Y
|
N
|
S
|
R
|
A
|
170 |
T
|
A
|
F
|
I
|
K
|
I
|
T
|
V
|
V
|
W
|
180 |
L
|
I
|
S
|
I
|
G
|
I
|
A
|
I
|
P
|
V
|
190 |
ECL2 | |||||||||
P
|
I
|
K
|
G
|
I
|
E
|
T
|
D
|
V
|
D
|
200 |
N
|
P
|
N
|
N
|
I
|
T
|
C
|
V
|
L
|
T
|
210 |
TM5 | |||||||||
K
|
E
|
R
|
F
|
G
|
D
|
F
|
M
|
L
|
F
|
220 |
G
|
S
|
L
|
A
|
A
|
F
|
F
|
T
|
P
|
L
|
230 |
A
|
I
|
M
|
I
|
V
|
T
|
Y
|
F
|
L
|
T
|
240 |
I
|
H
|
A
|
L
|
Q
|
K
|
K
|
A
|
Y
|
L
|
250 |
ICL3 | |||||||||
V
|
K
|
N
|
K
|
P
|
P
|
Q
|
R
|
L
|
T
|
260 |
W
|
L
|
T
|
V
|
S
|
T
|
V
|
F
|
Q
|
R
|
270 |
D
|
E
|
T
|
P
|
C
|
S
|
S
|
P
|
E
|
K
|
280 |
V
|
A
|
M
|
L
|
D
|
G
|
S
|
R
|
K
|
D
|
290 |
K
|
A
|
L
|
P
|
N
|
S
|
G
|
D
|
E
|
T
|
300 |
L
|
M
|
R
|
R
|
T
|
S
|
T
|
I
|
G
|
K
|
310 |
TM6 | |||||||||
K
|
S
|
V
|
Q
|
T
|
I
|
S
|
N
|
E
|
Q
|
320 |
R
|
A
|
S
|
K
|
V
|
L
|
G
|
I
|
V
|
F
|
330 |
F
|
L
|
F
|
L
|
L
|
M
|
W
|
C
|
P
|
F
|
340 |
F
|
I
|
T
|
N
|
I
|
T
|
L
|
V
|
L
|
C
|
350 |
ECL3 | TM7 | ||||||||
D
|
S
|
C
|
N
|
Q
|
T
|
T
|
L
|
Q
|
M
|
360 |
L
|
L
|
E
|
I
|
F
|
V
|
W
|
I
|
G
|
Y
|
370 |
V
|
S
|
S
|
G
|
V
|
N
|
P
|
L
|
V
|
Y
|
380 |
H8 | |||||||||
T
|
L
|
F
|
N
|
K
|
T
|
F
|
R
|
D
|
A
|
390 |
F
|
G
|
R
|
Y
|
I
|
T
|
C
|
N
|
Y
|
R
|
400 |
C-term | |||||||||
A
|
T
|
K
|
S
|
V
|
K
|
T
|
L
|
R
|
K
|
410 |
R
|
S
|
S
|
K
|
I
|
Y
|
F
|
R
|
N
|
P
|
420 |
M
|
A
|
E
|
N
|
S
|
K
|
F
|
F
|
K
|
K
|
430 |
H
|
G
|
I
|
R
|
N
|
G
|
I
|
N
|
P
|
A
|
440 |
M
|
Y
|
Q
|
S
|
P
|
M
|
R
|
L
|
R
|
S
|
450 |
S
|
T
|
I
|
Q
|
S
|
S
|
S
|
I
|
I
|
L
|
460 |
L
|
D
|
T
|
L
|
L
|
L
|
T
|
E
|
N
|
E
|
470 |
G
|
D
|
K
|
T
|
E
|
E
|
Q
|
V
|
S
|
Y
|
480 |
V
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
5-hydroxytryptamine