GPR34 (gpr34_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR34
GENE
GPR34
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Probable G-protein coupled receptor 34
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
R
|
S
|
H
|
T
|
I
|
T
|
M
|
T
|
T
|
10 |
T
|
S
|
V
|
S
|
S
|
W
|
P
|
Y
|
S
|
S
|
20 |
H
|
R
|
M
|
R
|
F
|
I
|
T
|
N
|
H
|
S
|
30 |
D
|
Q
|
P
|
P
|
Q
|
N
|
F
|
S
|
A
|
T
|
40 |
P
|
N
|
V
|
T
|
T
|
C
|
P
|
M
|
D
|
E
|
50 |
TM1 | |||||||||
K
|
L
|
L
|
S
|
T
|
V
|
L
|
T
|
T
|
S
|
60 |
Y
|
S
|
V
|
I
|
F
|
I
|
V
|
G
|
L
|
V
|
70 |
G
|
N
|
I
|
I
|
A
|
L
|
Y
|
V
|
F
|
L
|
80 |
ICL1 | TM2 | ||||||||
G
|
I
|
H
|
R
|
K
|
R
|
N
|
S
|
I
|
Q
|
90 |
I
|
Y
|
L
|
L
|
N
|
V
|
A
|
I
|
A
|
D
|
100 |
L
|
L
|
L
|
I
|
F
|
C
|
L
|
P
|
F
|
R
|
110 |
I
|
M
|
Y
|
H
|
I
|
N
|
Q
|
N
|
K
|
W
|
120 |
ECL1 | TM3 | ||||||||
T
|
L
|
G
|
V
|
I
|
L
|
C
|
K
|
V
|
V
|
130 |
G
|
T
|
L
|
F
|
Y
|
M
|
N
|
M
|
Y
|
I
|
140 |
S
|
I
|
I
|
L
|
L
|
G
|
F
|
I
|
S
|
L
|
150 |
D
|
R
|
Y
|
I
|
K
|
I
|
N
|
R
|
S
|
I
|
160 |
ICL2 | |||||||||
Q
|
Q
|
R
|
K
|
A
|
I
|
T
|
T
|
K
|
Q
|
170 |
TM4 | |||||||||
S
|
I
|
Y
|
V
|
C
|
C
|
I
|
V
|
W
|
M
|
180 |
L
|
A
|
L
|
G
|
G
|
F
|
L
|
T
|
M
|
I
|
190 |
I
|
L
|
T
|
L
|
K
|
K
|
G
|
G
|
H
|
N
|
200 |
ECL2 | |||||||||
S
|
T
|
M
|
C
|
F
|
H
|
Y
|
R
|
D
|
K
|
210 |
TM5 | |||||||||
H
|
N
|
A
|
K
|
G
|
E
|
A
|
I
|
F
|
N
|
220 |
F
|
I
|
L
|
V
|
V
|
M
|
F
|
W
|
L
|
I
|
230 |
F
|
L
|
L
|
I
|
I
|
L
|
S
|
Y
|
I
|
K
|
240 |
I
|
G
|
K
|
N
|
L
|
L
|
R
|
I
|
S
|
K
|
250 |
ICL3 | TM6 | ||||||||
R
|
R
|
S
|
K
|
F
|
P
|
N
|
S
|
G
|
K
|
260 |
Y
|
A
|
T
|
T
|
A
|
R
|
N
|
S
|
F
|
I
|
270 |
V
|
L
|
I
|
I
|
F
|
T
|
I
|
C
|
F
|
V
|
280 |
P
|
Y
|
H
|
A
|
F
|
R
|
F
|
I
|
Y
|
I
|
290 |
ECL3 | TM7 | ||||||||
S
|
S
|
Q
|
L
|
N
|
V
|
S
|
S
|
C
|
Y
|
300 |
W
|
K
|
E
|
I
|
V
|
H
|
K
|
T
|
N
|
E
|
310 |
I
|
M
|
L
|
V
|
L
|
S
|
S
|
F
|
N
|
S
|
320 |
C
|
L
|
D
|
P
|
V
|
M
|
Y
|
F
|
L
|
M
|
330 |
H8 | |||||||||
S
|
S
|
N
|
I
|
R
|
K
|
I
|
M
|
C
|
Q
|
340 |
L
|
L
|
F
|
R
|
R
|
F
|
Q
|
G
|
E
|
P
|
350 |
C-term | |||||||||
S
|
R
|
S
|
E
|
S
|
T
|
S
|
E
|
F
|
K
|
360 |
P
|
G
|
Y
|
S
|
L
|
H
|
D
|
T
|
S
|
V
|
370 |
A
|
V
|
K
|
I
|
Q
|
S
|
S
|
S
|
K
|
S
|
380 |
T
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
lysophosphatidylserine