GPR34 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

Nov. 8, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

LYSOPHOSPHATIDIC ACID - Agonist chembl_ligand pubchem

ENDOGENOUS LIGANDS

lysophosphatidylserine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL3 P 256 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 P 256 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 F 255 - G.H5 F 334 G.H5.06
Hydrophobic TM6 T 264 6x34 G.H5 F 354 G.H5.26
Van-der-waals TM6 T 264 6x34 G.H5 F 354 G.H5.26
Hydrophobic TM6 Y 261 6x31 G.H5 I 344 G.H5.16
Van-der-waals TM6 Y 261 6x31 G.H5 I 344 G.H5.16
Polar TM2 N 87 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 87 2x37 G.H5 D 350 G.H5.22
Polar ICL3 N 257 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 N 257 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 P 256 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 156 3x54 G.H5 L 353 G.H5.25
Polar TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 K 155 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 155 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 245 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 N 257 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 N 257 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 Y 261 6x31 G.H5 K 345 G.H5.17
Hydrophobic TM6 S 268 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 268 6x38 G.H5 L 353 G.H5.25
Polar H8 S 332 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 S 332 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 260 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 260 6x30 G.H5 F 354 G.H5.26
Polar TM7 M 330 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM7 M 330 7x56 G.H5 F 354 G.H5.26
Van-der-waals TM7 M 330 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM7 M 330 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM2 I 89 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 T 264 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 264 6x34 G.H5 L 353 G.H5.25
Polar TM3 K 155 3x53 G.H5 N 347 G.H5.19
Polar TM6 N 267 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 N 267 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 N 267 6x37 G.H5 L 353 G.H5.25
Hydrophobic H8 S 331 8x47 G.H5 F 354 G.H5.26
Hydrophobic ICL3 F 255 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 F 255 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 F 255 - G.H5 D 341 G.H5.13
Hydrophobic TM5 I 248 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 241 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 156 3x54 G.H5 L 348 G.H5.20
Aromatic ICL3 F 255 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 F 255 - G.S6 Y 320 G.S6.02
Polar TM6 Y 261 6x31 G.H5 D 341 G.H5.13
Hydrophobic TM6 Y 261 6x31 G.H5 D 341 G.H5.13
Van-der-waals TM6 Y 261 6x31 G.H5 D 341 G.H5.13
Hydrophobic TM7 Y 327 7x53 G.H5 G 352 G.H5.24
Hydrophobic TM6 V 271 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM6 Y 261 6x31 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 152 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 152 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 260 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM3 I 156 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 156 3x54 G.H5 C 351 G.H5.23
Polar H8 S 331 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 T 264 6x34 G.H5 L 348 G.H5.20