Structure information

GPR34

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8WRB

SPECIES

Homo sapiens

RESOLUTION

2.910

PREFERRED CHAIN

R

REFERENCE

10.1371/JOURNAL.PBIO.3002387

PUBLICATION DATE

Nov. 8, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
LYSOPHOSPHATIDIC ACID Y135 3.33x33 TM3 hydrophobic
LYSOPHOSPHATIDIC ACID M136 3.34x34 TM3 hydrophobic
LYSOPHOSPHATIDIC ACID A182 4.53x53 TM4 hydrophobic
LYSOPHOSPHATIDIC ACID M189 4.60x60 TM4 hydrophobic
LYSOPHOSPHATIDIC ACID R208 ECL2 polar (charge-assisted hydrogen bond)
LYSOPHOSPHATIDIC ACID F219 5.39x39 TM5 hydrophobic
LYSOPHOSPHATIDIC ACID N220 5.40x40 TM5 polar (hydrogen bond)
LYSOPHOSPHATIDIC ACID N220 5.40x40 TM5 Van der Waals
LYSOPHOSPHATIDIC ACID L223 5.43x43 TM5 hydrophobic
LYSOPHOSPHATIDIC ACID L223 5.43x43 TM5 Van der Waals
LYSOPHOSPHATIDIC ACID M226 5.46x46 TM5 Van der Waals
LYSOPHOSPHATIDIC ACID M226 5.46x46 TM5 hydrophobic

Ligands

LYSOPHOSPHATIDIC ACID

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Residue Diagrams

I N G V L G V I F I V S Y S T T L V T S 1 L N V A I A D L L L I F C L P F R I M Y 2 F G L L I I S I Y M N M Y F L T G V V K 3 S I Y V C C I V W M L A L G G F L T M I 4 Y S L I I L L F I L W F M V V L I F N F 5 S F I V L I I F I T C F V P Y H A F R F I 6 V P D L C S N F S S L V L M I E N T K 7
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ICL1 R K R ICL1ECL1 N K W T L ECL1ICL2 I Q Q R K A I T T ICL2ECL2 G H N S T M C F H Y R D K H N A ECL2ICL3 R R S K F P N ICL3ECL3 Q L N V S ECL3N-term M R S H T I T M T T T S V S S W P Y S S H R M R F I T N H S D Q P P Q N F S A T P N V T T C P M D E K N-termC-term G E P S R S E S T S E F K P G Y S L H D T S V A V K I Q S S S K S T C-term L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N R S K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G K N L L R I S K S G K Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N M C Q R F Q I R K I L L F R
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR34
TM3
3x33 3.33x33 Y135
3x34 3.34x34 M136
TM4
4x53 4.53x53 A182
4x60 4.60x60 M189
TM5
5x39 5.39x39 F219
5x40 5.40x40 N220
5x43 5.43x43 L223
5x46 5.46x46 M226