GPR34 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8SAI

RESOLUTION

3.3 Å

REFERENCE

10.1073/PNAS.2308435120

PUBLICATION DATE

Oct. 4, 2023

3D VIEW

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LIGAND INTERACTIONS

51 interactions (Click to see)

LIGANDS

O-[(S)-Hydroxy{[(2s)-2-Hydroxy-3-(Octadec-9-Enoyloxy)propyl]oxy}phosphoryl]-L-Serine - Agonist pubchem

PHYSIOLOGICAL LIGANDS

lysophosphatidylserine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 R 163 - G.H5 I 343 G.H5.15
Hydrophobic TM6 S 268 6x38 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 156 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL3 F 255 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 F 255 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 K 260 6x30 G.H5 I 344 G.H5.16
Van-der-waals TM6 K 260 6x30 G.H5 I 344 G.H5.16
Hydrophobic TM3 S 159 3x57 G.H5 I 344 G.H5.16
Van-der-waals TM3 S 159 3x57 G.H5 I 344 G.H5.16
Ionic TM6 K 260 6x30 G.H5 D 341 G.H5.13
Polar TM6 K 260 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM6 K 260 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 K 260 6x30 G.H5 D 341 G.H5.13
Polar ICL2 Q 162 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 162 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 162 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 I 241 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 162 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 Q 162 - G.S3 L 194 G.S3.01
Polar TM6 N 267 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 N 267 6x37 G.H5 L 353 G.H5.25
Polar TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 T 263 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 156 3x54 G.H5 L 353 G.H5.25
Polar TM6 T 263 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 T 263 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 L 245 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 245 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 F 255 - G.H5 F 334 G.H5.06
Polar TM6 T 263 6x33 G.H5 L 353 G.H5.25
Polar TM3 S 159 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 159 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 159 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM6 G 259 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 G 259 6x29 G.H5 F 354 G.H5.26
Polar ICL3 N 257 - G.H5 D 341 G.H5.13
Hydrophobic TM3 I 156 3x54 G.H5 C 351 G.H5.23
Ionic ICL3 R 252 - G.H5 D 341 G.H5.13
Hydrophobic TM7 M 330 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 M 330 7x56 G.H5 L 353 G.H5.25