MC3 receptor (mc3r_mouse)
FAMILY
Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC3 receptor
GENE
Mc3r
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Melanocortin receptor 3, MC3-R
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
S
|
S
|
C
|
C
|
L
|
S
|
S
|
V
|
10 |
S
|
P
|
M
|
L
|
P
|
N
|
L
|
S
|
E
|
H
|
20 |
P
|
A
|
A
|
P
|
P
|
A
|
S
|
N
|
R
|
S
|
30 |
G
|
S
|
G
|
F
|
C
|
E
|
Q
|
V
|
F
|
I
|
40 |
TM1 | |||||||||
K
|
P
|
E
|
V
|
F
|
L
|
A
|
L
|
G
|
I
|
50 |
V
|
S
|
L
|
M
|
E
|
N
|
I
|
L
|
V
|
I
|
60 |
ICL1 | |||||||||
L
|
A
|
V
|
V
|
R
|
N
|
G
|
N
|
L
|
H
|
70 |
TM2 | |||||||||
S
|
P
|
M
|
Y
|
F
|
F
|
L
|
C
|
S
|
L
|
80 |
A
|
A
|
A
|
D
|
M
|
L
|
V
|
S
|
L
|
S
|
90 |
N
|
S
|
L
|
E
|
T
|
I
|
M
|
I
|
A
|
V
|
100 |
ECL1 | |||||||||
I
|
N
|
S
|
D
|
S
|
L
|
T
|
L
|
E
|
D
|
110 |
TM3 | |||||||||
Q
|
F
|
I
|
Q
|
H
|
M
|
D
|
N
|
I
|
F
|
120 |
D
|
S
|
M
|
I
|
C
|
I
|
S
|
L
|
V
|
A
|
130 |
S
|
I
|
C
|
N
|
L
|
L
|
A
|
I
|
A
|
I
|
140 |
D
|
R
|
Y
|
V
|
T
|
I
|
F
|
Y
|
A
|
L
|
150 |
ICL2 | TM4 | ||||||||
R
|
Y
|
H
|
S
|
I
|
M
|
T
|
V
|
R
|
K
|
160 |
A
|
L
|
T
|
L
|
I
|
G
|
V
|
I
|
W
|
V
|
170 |
C
|
C
|
G
|
I
|
C
|
G
|
V
|
M
|
F
|
I
|
180 |
ECL2 | TM5 | ||||||||
I
|
Y
|
S
|
E
|
S
|
K
|
M
|
V
|
I
|
V
|
190 |
C
|
L
|
I
|
T
|
M
|
F
|
F
|
A
|
M
|
V
|
200 |
L
|
L
|
M
|
G
|
T
|
L
|
Y
|
I
|
H
|
M
|
210 |
F
|
L
|
F
|
A
|
R
|
L
|
H
|
V
|
Q
|
R
|
220 |
ICL3 | |||||||||
I
|
A
|
V
|
L
|
P
|
P
|
A
|
G
|
V
|
V
|
230 |
TM6 | |||||||||
A
|
P
|
Q
|
Q
|
H
|
S
|
C
|
M
|
K
|
G
|
240 |
A
|
V
|
T
|
I
|
T
|
I
|
L
|
L
|
G
|
V
|
250 |
F
|
I
|
F
|
C
|
W
|
A
|
P
|
F
|
F
|
L
|
260 |
H
|
L
|
V
|
L
|
I
|
I
|
T
|
C
|
P
|
T
|
270 |
ECL3 | |||||||||
N
|
P
|
Y
|
C
|
I
|
C
|
Y
|
T
|
A
|
H
|
280 |
TM7 | |||||||||
F
|
N
|
T
|
Y
|
L
|
V
|
L
|
I
|
M
|
C
|
290 |
N
|
S
|
V
|
I
|
D
|
P
|
L
|
I
|
Y
|
A
|
300 |
H8 | |||||||||
F
|
R
|
S
|
L
|
E
|
L
|
R
|
N
|
T
|
F
|
310 |
K
|
E
|
I
|
L
|
C
|
G
|
C
|
N
|
S
|
M
|
320 |
C-term | |||||
N
|
L
|
G
|
|||
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
agouti
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available