RXFP3 (rl3r1_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Relaxin family peptide receptors RXFP3
GENE
RXFP3 (GPCR135, RLN3R1, SALPR)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Relaxin-3 receptor 1, RLN3 receptor 1, G protein-coupled receptor SALPR, G-protein coupled receptor GPCR135, Relaxin family peptide receptor 3, Somatostatin- and angiotensin-like peptide receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
Q
|
M
|
A
|
D
|
A
|
A
|
T
|
I
|
A
|
10 |
T
|
M
|
N
|
K
|
A
|
A
|
G
|
G
|
D
|
K
|
20 |
L
|
A
|
E
|
L
|
F
|
S
|
L
|
V
|
P
|
D
|
30 |
L
|
L
|
E
|
A
|
A
|
N
|
T
|
S
|
G
|
N
|
40 |
A
|
S
|
L
|
Q
|
L
|
P
|
D
|
L
|
W
|
W
|
50 |
E
|
L
|
G
|
L
|
E
|
L
|
P
|
D
|
G
|
A
|
60 |
P
|
P
|
G
|
H
|
P
|
P
|
G
|
S
|
G
|
G
|
70 |
TM1 | |||||||||
A
|
E
|
S
|
A
|
D
|
T
|
E
|
A
|
R
|
V
|
80 |
R
|
I
|
L
|
I
|
S
|
V
|
V
|
Y
|
W
|
V
|
90 |
V
|
C
|
A
|
L
|
G
|
L
|
A
|
G
|
N
|
L
|
100 |
L
|
V
|
L
|
Y
|
L
|
M
|
K
|
S
|
M
|
Q
|
110 |
ICL1 | TM2 | ||||||||
G
|
W
|
R
|
K
|
S
|
S
|
I
|
N
|
L
|
F
|
120 |
V
|
T
|
N
|
L
|
A
|
L
|
T
|
D
|
F
|
Q
|
130 |
F
|
V
|
L
|
T
|
L
|
P
|
F
|
W
|
A
|
V
|
140 |
ECL1 | |||||||||
E
|
N
|
A
|
L
|
D
|
F
|
K
|
W
|
P
|
F
|
150 |
TM3 | |||||||||
G
|
K
|
A
|
M
|
C
|
K
|
I
|
V
|
S
|
M
|
160 |
V
|
T
|
S
|
M
|
N
|
M
|
Y
|
A
|
S
|
V
|
170 |
F
|
F
|
L
|
T
|
A
|
M
|
S
|
V
|
T
|
R
|
180 |
ICL2 | |||||||||
Y
|
H
|
S
|
V
|
A
|
S
|
A
|
L
|
K
|
S
|
190 |
H
|
R
|
T
|
R
|
G
|
H
|
G
|
R
|
G
|
D
|
200 |
C
|
C
|
G
|
R
|
S
|
L
|
G
|
D
|
S
|
C
|
210 |
TM4 | |||||||||
C
|
F
|
S
|
A
|
K
|
A
|
L
|
C
|
V
|
W
|
220 |
I
|
W
|
A
|
L
|
A
|
A
|
L
|
A
|
S
|
L
|
230 |
ECL2 | |||||||||
P
|
S
|
A
|
I
|
F
|
S
|
T
|
T
|
V
|
K
|
240 |
V
|
M
|
G
|
E
|
E
|
L
|
C
|
L
|
V
|
R
|
250 |
F
|
P
|
D
|
K
|
L
|
L
|
G
|
R
|
D
|
R
|
260 |
TM5 | |||||||||
Q
|
F
|
W
|
L
|
G
|
L
|
Y
|
H
|
S
|
Q
|
270 |
K
|
V
|
L
|
L
|
G
|
F
|
V
|
L
|
P
|
L
|
280 |
G
|
I
|
I
|
I
|
L
|
C
|
Y
|
L
|
L
|
L
|
290 |
V
|
R
|
F
|
I
|
A
|
D
|
R
|
R
|
A
|
A
|
300 |
G
|
T
|
K
|
G
|
G
|
A
|
A
|
V
|
A
|
G
|
310 |
ICL3 | TM6 | ||||||||
G
|
R
|
P
|
T
|
G
|
A
|
S
|
A
|
R
|
R
|
320 |
L
|
S
|
K
|
V
|
T
|
K
|
S
|
V
|
T
|
I
|
330 |
V
|
V
|
L
|
S
|
F
|
F
|
L
|
C
|
W
|
L
|
340 |
P
|
N
|
Q
|
A
|
L
|
T
|
T
|
W
|
S
|
I
|
350 |
ECL3 | |||||||||
L
|
I
|
K
|
F
|
N
|
A
|
V
|
P
|
F
|
S
|
360 |
TM7 | |||||||||
Q
|
E
|
Y
|
F
|
L
|
C
|
Q
|
V
|
Y
|
A
|
370 |
F
|
P
|
V
|
S
|
V
|
C
|
L
|
A
|
H
|
S
|
380 |
N
|
S
|
C
|
L
|
N
|
P
|
V
|
L
|
Y
|
C
|
390 |
H8 | |||||||||
L
|
V
|
R
|
R
|
E
|
F
|
R
|
K
|
A
|
L
|
400 |
K
|
S
|
L
|
L
|
W
|
R
|
I
|
A
|
S
|
P
|
410 |
C-term | |||||||||
S
|
I
|
T
|
S
|
M
|
R
|
P
|
F
|
T
|
A
|
420 |
T
|
T
|
K
|
P
|
E
|
H
|
E
|
D
|
Q
|
G
|
430 |
L
|
Q
|
A
|
P
|
A
|
P
|
P
|
H
|
A
|
A
|
440 |
A
|
E
|
P
|
D
|
L
|
L
|
Y
|
Y
|
P
|
P
|
450 |
G
|
V
|
V
|
V
|
Y
|
S
|
G
|
G
|
R
|
Y
|
460 |
D
|
L
|
L
|
P
|
S
|
S
|
S
|
A
|
Y
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
relaxin-3, relaxin, relaxin-3 (B chain), INSL5
STRUCTURE MODELS
STRUCTURES
No structures available