MC2 receptor (acthr_mouse)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

Mc2r (Acthr)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Adrenocorticotropic hormone receptor, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
K
H
I
I
N
S
Y
E
H
10
                   
T
N
D
T
A
R
N
N
S
D
20
            TM1  
C
P
D
V
V
L
P
E
E
I
30
                   
F
F
T
I
S
V
I
G
I
L
40
                   
E
N
L
I
V
L
L
A
V
I
50
    ICL1 TM2  
K
N
K
N
L
Q
S
P
M
Y
60
                   
F
F
I
C
S
L
A
I
S
D
70
                   
M
L
G
S
L
Y
K
I
L
E
80
                   
N
I
L
I
M
F
R
N
M
G
90
ECL1   TM3    
Y
L
K
P
R
G
S
F
E
S
100
                   
T
A
D
D
I
I
D
C
M
F
110
                   
I
L
S
L
L
G
S
I
F
S
120
                   
L
S
V
I
A
A
D
R
Y
I
130
        ICL2    
T
I
F
H
A
L
Q
Y
H
S
140
    TM4          
I
V
T
M
R
R
T
I
I
T
150
                   
L
T
I
I
W
M
F
C
T
G
160
                   
S
G
I
T
M
V
I
F
S
H
170
TM5              
H
I
P
T
V
L
T
F
T
S
180
                   
L
F
P
L
M
L
V
F
I
L
190
                   
C
L
Y
I
H
M
F
L
L
A
200
                   
R
S
H
A
R
K
I
S
T
L
210
ICL3 TM6      
P
R
T
N
M
K
G
A
M
T
220
                   
L
T
I
L
L
G
V
F
I
F
230
                   
C
W
A
P
F
V
L
H
V
L
240
          ECL3 TM7
L
M
T
F
C
P
N
N
P
Y
250
               
C
V
C
Y
M
S
L
F
Q
V
260
                   
N
G
M
L
I
M
C
N
A
V
270
                   
I
D
P
F
I
Y
A
F
R
S
280
H8                
P
E
L
R
D
A
F
K
R
M
290
        C-term
L
F
C
N
R
Y

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 K N L Q ICL1ECL1 Y L K P R ECL1ICL2 A L Q Y H S I V ICL2ECL2 H ECL2ICL3 T L P R T ICL3ECL3 P N ECL3N-term M K H I I N S Y E H T N D T A R N N S D C P D V V L N-termC-term R Y C-term P E E I F F T I S V I G I L E N L I V L L A V I K N S P M Y F F I C S L A I S D M L G S L Y K I L E N I L I M F R N M G G S F E S T A D D I I D C M F I L S L L G S I F S L S V I A A D R Y I T I F H T M R R T I I T L T I I W M F C T G S G I T M V I F S H I P T V L T F T S L F P L M L V F I L C L Y I H M F L L A R S H A R K I S N M K G A M T L T I L L G V F I F C W A P F V L H V L L M T F C N P Y C V C Y M S L F Q V N G M L I M C N A V I D P F I Y A F R S P E F K R N L R D A M L F C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N E L I G I V S I T F F I E E P 1 C S L A I S D M L G S L Y K I L E N I L 2 V S L S F I S G L L S L I F M C D I I D 3 T I I T L T I I W M F C T G S G I T M V 4 Y L C L I F V L M L P F L S T F T L V T 5 T I L L G V F I F C W A P F V L H V L L 6 F P D I V A N C M I L M G N V Q F L S 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

2 mutation data points available.

PHYSIOLOGICAL LIGANDS

ACTH

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available