MRGPRX2 (mrgx2_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans MRGPRX2
GENE
MRGPRX2 (MRGX2)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Mas-related G-protein coupled receptor member X2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
P
|
T
|
T
|
P
|
A
|
W
|
G
|
T
|
10 |
E
|
S
|
T
|
T
|
V
|
N
|
G
|
N
|
D
|
Q
|
20 |
A
|
L
|
L
|
L
|
L
|
C
|
G
|
K
|
E
|
T
|
30 |
TM1 | |||||||||
L
|
I
|
P
|
V
|
F
|
L
|
I
|
L
|
F
|
I
|
40 |
A
|
L
|
V
|
G
|
L
|
V
|
G
|
N
|
G
|
F
|
50 |
V
|
L
|
W
|
L
|
L
|
G
|
F
|
R
|
M
|
R
|
60 |
ICL1 | TM2 | ||||||||
R
|
N
|
A
|
F
|
S
|
V
|
Y
|
V
|
L
|
S
|
70 |
L
|
A
|
G
|
A
|
D
|
F
|
L
|
F
|
L
|
C
|
80 |
F
|
Q
|
I
|
I
|
N
|
C
|
L
|
V
|
Y
|
L
|
90 |
ECL1 | |||||||||
S
|
N
|
F
|
F
|
C
|
S
|
I
|
S
|
I
|
N
|
100 |
TM3 | |||||||||
F
|
P
|
S
|
F
|
F
|
T
|
T
|
V
|
M
|
T
|
110 |
C
|
A
|
Y
|
L
|
A
|
G
|
L
|
S
|
M
|
L
|
120 |
S
|
T
|
V
|
S
|
T
|
E
|
R
|
C
|
L
|
S
|
130 |
ICL2 | |||||||||
V
|
L
|
W
|
P
|
I
|
W
|
Y
|
R
|
C
|
R
|
140 |
TM4 | |||||||||
R
|
P
|
R
|
H
|
L
|
S
|
A
|
V
|
V
|
C
|
150 |
V
|
L
|
L
|
W
|
A
|
L
|
S
|
L
|
L
|
L
|
160 |
S
|
I
|
L
|
E
|
G
|
K
|
F
|
C
|
G
|
F
|
170 |
ECL2 | TM5 | ||||||||
L
|
F
|
S
|
D
|
G
|
D
|
S
|
G
|
W
|
C
|
180 |
Q
|
T
|
F
|
D
|
F
|
I
|
T
|
A
|
A
|
W
|
190 |
L
|
I
|
F
|
L
|
F
|
M
|
V
|
L
|
C
|
G
|
200 |
S
|
S
|
L
|
A
|
L
|
L
|
V
|
R
|
I
|
L
|
210 |
ICL3 | TM6 | ||||||||
C
|
G
|
S
|
R
|
G
|
L
|
P
|
L
|
T
|
R
|
220 |
L
|
Y
|
L
|
T
|
I
|
L
|
L
|
T
|
V
|
L
|
230 |
V
|
F
|
L
|
L
|
C
|
G
|
L
|
P
|
F
|
G
|
240 |
I
|
Q
|
W
|
F
|
L
|
I
|
L
|
W
|
I
|
W
|
250 |
ECL3 | TM7 | ||||||||
K
|
D
|
S
|
D
|
V
|
L
|
F
|
C
|
H
|
I
|
260 |
H
|
P
|
V
|
S
|
V
|
V
|
L
|
S
|
S
|
L
|
270 |
N
|
S
|
S
|
A
|
N
|
P
|
I
|
I
|
Y
|
F
|
280 |
F
|
V
|
G
|
S
|
F
|
R
|
K
|
Q
|
W
|
R
|
290 |
C-term | |||||||||
L
|
Q
|
Q
|
P
|
I
|
L
|
K
|
L
|
A
|
L
|
300 |
Q
|
R
|
A
|
L
|
Q
|
D
|
I
|
A
|
E
|
V
|
310 |
D
|
H
|
S
|
E
|
G
|
C
|
F
|
R
|
Q
|
G
|
320 |
T
|
P
|
E
|
M
|
S
|
R
|
S
|
S
|
L
|
V
|
330 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PAMP-20