MRGPRX2 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7S8O

RESOLUTION

2.6 Å

REFERENCE

10.1038/S41586-021-04126-6

PUBLICATION DATE

Nov. 17, 2021

3D VIEW

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LIGAND INTERACTIONS

18 interactions (Click to see)

LIGANDS

(R)-ZINC-3573 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

PAMP-20



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 C 139 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 C 139 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 C 139 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM2 F 64 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 64 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL3 G 215 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 R 138 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 216 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 C 139 34x55 G.S3 L 194 G.S3.01
Hydrophobic TM6 L 221 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 221 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 138 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 138 34x54 G.hns1 R 32 G.hns1.03
Polar ICL2 Y 137 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 137 34x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 131 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 131 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 140 34x56 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 140 34x56 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 S 130 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 221 6x33 G.H5 L 348 G.H5.20
Ionic ICL3 R 214 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 214 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 214 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 214 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 134 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 134 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 134 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM3 V 131 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 127 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 127 3x50 G.H5 L 353 G.H5.25
Aromatic ICL3 R 214 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 214 - G.S6 Y 320 G.S6.02
Polar ICL3 R 214 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 214 - G.S6 I 319 G.S6.01
Polar TM2 N 62 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 I 135 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 Y 137 34x53 G.H5 N 347 G.H5.19
Polar TM3 S 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 130 3x53 G.H5 N 347 G.H5.19
Polar ICL2 P 134 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 I 135 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL3 L 216 - G.H5 L 348 G.H5.20
Polar TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 C 351 G.H5.23
Polar ICL2 R 138 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 138 34x54 G.S1 E 33 G.S1.01