Data showed in this table is continously collected from the Guide to Pharmacology database. Ref
RECEPTOR | ENDOGENOUS LIGANDS | pEC50 | pKi | REFERENCES | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Class | Receptor family | UniProt | IUPHAR | Species | Ligand | GtP Classification |
Potency Ranking |
Type | Min | Mid | Max | Min | Mid | Max | |
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1F | 5-HT1F | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 7.7 | 7.9 | 8.0 | Refs | |||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT4R | 5-HT4 | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.7 | 7.5 | 8.2 | Refs | |||
A (Rhodopsin) | Thyrotropin-releasing hormone | TRFR | TRH1 | Human | Trh | Principal | 1 | Peptide | 7.4 | 7.4 | Refs | ||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR3 | LPA3 | Human | Farnesyl Monophosphate | None | 2 | Small molecule | Refs | ||||||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl2 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Dopamine | DRD3 | D3 | Human | Dopamine | Principal | 1 | Small molecule | 6.4 | 6.9 | 7.3 | Refs | |||
A (Rhodopsin) | Galanin | GALR2 | GAL2 | Rat | Galanin | 2 | Peptide | 8.3 | 8.3 | 8.3 | 8.4 | 8.4 | Refs | ||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl3 | 5 | Peptide | 8.0 | 8.5 | 8.9 | Refs | ||||
C (Glutamate) | Metabotropic glutamate | GRM8 | mGlu8 | Human | L-Glutamic Acid | None | 1 | Small molecule | 4.9 | 5.3 | 5.6 | Refs | |||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR3 | S1P3 | Human | Sphingosylphosphorylcholine | 2 | Small molecule | ||||||||
A (Rhodopsin) | Leukotriene | OXER1 | OXE | Human | 5-Oxo-20-Hete | None | 6 | Small molecule | 6.5 | 6.5 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl16 | 7 | Peptide | ||||||||
C (Glutamate) | Metabotropic glutamate | GRM4 | mGlu4 | Rat | L-Glutamic Acid | None | 2 | Small molecule | 4.7 | 5.1 | 5.5 | 4.9 | 5.2 | 5.5 | Refs |
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | Human | Prrp-31 | 3 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GPR35 | GPR35 | Human | Kynurenic Acid | None | 2 | Small molecule | 3.9 | 5.0 | 5.0 | Refs | |||
A (Rhodopsin) | Leukotriene | CLTR1 | CysLT1 | Human | Ltc4 | None | 2 | Small molecule | 7.4 | 7.6 | 7.7 | 7.0 | 7.6 | 8.1 | Refs |
A (Rhodopsin) | Melatonin | MTR1B | MT2 | Human | Melatonin | Principal | 1 | Small molecule | 9.4 | 9.6 | 9.8 | Refs | |||
A (Rhodopsin) | P2Y | P2RY4 | P2Y4 | Human | Atp | None | 2 | Small molecule | 5.7 | 5.4 | 5.4 | Refs | |||
A (Rhodopsin) | Prostanoid | PD2R | DP1 | Mouse | Pgd2 | None | 2 | Small molecule | 7.8 | 8.5 | 9.2 | Refs | |||
A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Human | Srif-14 | 1 | Peptide | 8.7 | 9.4 | 10.0 | Refs | ||||
A (Rhodopsin) | Proteinase-activated | PAR4 | PAR4 | Human | Cathepsin G | Peptide | |||||||||
A (Rhodopsin) | Vasopressin and oxytocin | OXYR | OT | Human | Vasopressin | 2 | Peptide | 7.3 | 8.3 | 9.3 | Refs | ||||
A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Rat | Srif-14 | 1 | Peptide | 9.0 | 9.1 | 9.1 | 8.9 | 9.7 | 10.5 | Refs | |
A (Rhodopsin) | Chemokine | CX3C1 | CX3CR1 | Human | Cx3Cl1 | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Class A orphan | LGR5 | LGR5 | Human | R-Spondin-3 | 3 | Peptide | 11.0 | 11.0 | Refs | |||||
A (Rhodopsin) | Proteinase-activated | PAR4 | PAR4 | Human | Cathepsin G | Peptide | |||||||||
A (Rhodopsin) | Prolactin-releasing peptide | PRLHR | PrRP | Human | Prrp-31 | 4 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | LGR5 | LGR5 | Human | R-Spondin-2 | 1 | Peptide | 12.0 | 12.0 | Refs | |||||
A (Rhodopsin) | Proteinase-activated | PAR4 | PAR4 | Human | Thrombin | Peptide | |||||||||
A (Rhodopsin) | Adren | ADRB3 | β3-adren | Rat | (&Plusmn;)-Adrenaline | None | 1 | Small molecule | 3.9 | 5.3 | 5.3 | Refs | |||
A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Rat | Pge1 | None | 2 | Small molecule | 7.0 | 7.0 | Refs | ||||
A (Rhodopsin) | Somatostatin | SSR4 | SST4 | Human | Srif-14 | 2 | Peptide | 8.4 | 8.9 | 9.3 | Refs | ||||
A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Mouse | Ltd4 | None | 3 | Small molecule | 8.1 | 8.3 | 8.4 | Refs | |||
A (Rhodopsin) | Opioid | OPRD | δ | Human | Dynorphin A | 5 | Peptide | 7.4 | 7.4 | Refs | |||||
A (Rhodopsin) | Class A orphan | GPR39 | GPR39 | Human | Zn2+ | None | Small molecule | Refs | |||||||
A (Rhodopsin) | Chemokine | CXCR4 | CXCR4 | Human | Cxcl12Γ | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Orexin | OX2R | OX2 | Human | Orexin-B | 1 | Peptide | 6.5 | 8.3 | 10.0 | Refs | ||||
A (Rhodopsin) | Neuromedin U | NMUR1 | NMU1 | Human | Neuromedin S-36 | 3 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Rat | Pge2 | None | 3 | Small molecule | 6.1 | 6.1 | 8.5 | 8.6 | 8.7 | Refs | |
A (Rhodopsin) | Chemerin | CML1 | hemerin | Human | 18r-Hepe | 2 | Small molecule | ||||||||
A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Mouse | Udp-Glucose | None | 6 | Small molecule | 7.1 | 7.2 | 7.3 | Refs | |||
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Rat | Pgf2Α | None | 2 | Small molecule | 8.4 | 8.4 | 7.4 | 7.4 | Refs | ||
A (Rhodopsin) | Opioid | OPRD | δ | Human | Β-Endorphin | 7 | Peptide | ||||||||
A (Rhodopsin) | Opioid | OPRK | κ | Mouse | Dynorphin B | 5 | Peptide | 8.1 | 9.0 | 9.9 | Refs | ||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1E | 5-HT1E | Human | 5-Hydroxytryptamine | None | 1 | Small molecule | 8.0 | 8.1 | 8.2 | Refs | |||
A (Rhodopsin) | GPR18, GPR55 and GPR119 | GPR55 | GPR55 | Human | Lysophosphatidylinositol | None | 4 | Small molecule | 5.5 | 6.4 | 7.3 | Refs | |||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2B | 5-HT2B | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 7.9 | 8.2 | 8.4 | Refs | |||
A (Rhodopsin) | Galanin | GALR3 | GAL3 | Rat | Galanin-Like Peptide | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR5 | LPA5 | Human | Lpa | None | 3 | Small molecule | 4.3 | 6.1 | 7.9 | Refs | |||
B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Rat | Vip | 3 | Peptide | 6.0 | 7.0 | 8.7 | 6.0 | 6.9 | 8.4 | Refs | |
A (Rhodopsin) | Tachykinin | NK1R | NK1 | Human | Neuropeptide-Γ | None | 4 | Peptide | Refs | ||||||
A (Rhodopsin) | Adren | ADA2B | α2B-adren | Human | (-)-Adrenaline | None | 2 | Small molecule | 5.2 | 5.2 | Refs | ||||
A (Rhodopsin) | Peptide P518 | QRFPR | QRFP | Human | Qrfp26 (26rfa) | 2 | Peptide | 8.1 | 8.1 | Refs | |||||
A (Rhodopsin) | Leukotriene | CLTR1 | CysLT1 | Human | Lte4 | None | 3 | Small molecule | 6.4 | 6.7 | 7.2 | 7.1 | 7.5 | 7.8 | Refs |
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Vip | 1 | Peptide | 7.9 | 9.0 | 10.0 | 8.5 | 9.2 | 9.8 | Refs | |
A (Rhodopsin) | Galanin | GALR1 | GAL1 | Rat | Galanin | 1 | Peptide | 9.8 | 9.8 | 9.3 | 9.8 | 10.3 | Refs | ||
A (Rhodopsin) | Class A orphan | LGR6 | LGR6 | Human | R-Spondin-1 | Peptide | Refs | ||||||||
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Rat | Pacap-27 | 2 | Peptide | 7.6 | 8.6 | 9.9 | 8.9 | 8.9 | Refs | ||
A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Rat | Pge2 | None | 2 | Small molecule | 7.5 | 7.9 | 8.3 | Refs | |||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl7 | 4 | Peptide | Refs | |||||||
A (Rhodopsin) | Free fatty acid | FFAR2 | FFA2 | Human | Butyric Acid | None | 4 | Small molecule | 2.9 | 3.8 | 4.6 | Refs | |||
A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Mouse | Srif-28 | 2 | Peptide | 8.4 | 9.3 | 10.2 | Refs | ||||
A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Human | Vasopressin | 1 | Peptide | 8.5 | 8.9 | 9.3 | Refs | ||||
A (Rhodopsin) | Prolactin-releasing peptide | PRLHR | PrRP | Human | Prrp-20 | 1 | Peptide | 9.0 | 9.3 | 9.6 | Refs | ||||
B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Vip | 3 | Peptide | 6.0 | 7.0 | 8.7 | 6.0 | 6.9 | 8.4 | Refs | |
A (Rhodopsin) | Relaxin family peptide | RL3R1 | RXFP3 | Human | Insl5 | 3 | Peptide | 7.0 | 7.0 | Refs | |||||
B1 (Secretin) | Glucagon receptor family | GIPR | GIP | Human | Gastric Inhibitory Polypeptide | Principal | 1 | Peptide | 9.1 | 9.1 | Refs | ||||
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Rat | Vip | 1 | Peptide | 7.9 | 9.0 | 10.0 | 8.5 | 9.2 | 9.8 | Refs | |
A (Rhodopsin) | Galanin | GALR1 | GAL1 | Human | Galanin | 2 | Peptide | 9.1 | 9.8 | 10.5 | Refs | ||||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR5 | S1P5 | Rat | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.4 | 8.2 | 8.9 | Refs | |||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR4 | S1P4 | Human | Dihydrosphingosine 1-Phosphate | None | 2 | Small molecule | |||||||
A (Rhodopsin) | Vasopressin and oxytocin | V1BR | V1B | Rat | Vasopressin | 1 | Peptide | 9.0 | 9.3 | 9.5 | Refs | ||||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR3 | S1P3 | Mouse | Sphingosine 1-Phosphate | None | 1 | Small molecule | 8.4 | 8.6 | 8.6 | Refs | |||
A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Human | Thromboxane A2 | 6 | Small molecule | ||||||||
C (Glutamate) | Metabotropic glutamate | GRM4 | mGlu4 | Rat | L-Serine-O-Phosphate | None | 1 | Small molecule | 5.9 | 5.9 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR10 | CCR10 | Human | Ccl28 | Peptide | |||||||||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl7 | 8 | Peptide | ||||||||
B1 (Secretin) | Glucagon receptor family | GIPR | GIP | Human | Gastric Inhibitory Polypeptide | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Histamine | HRH3 | H3 | Mouse | Histamine | Principal | 1 | Small molecule | 7.1 | 7.5 | 7.8 | Refs | |||
A (Rhodopsin) | Orexin | OX2R | OX2 | Human | Orexin-A | 1 | Peptide | 6.5 | 8.3 | 10.0 | Refs | ||||
A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Mouse | Pge2 | None | 1 | Small molecule | 7.3 | 7.7 | 7.7 | Refs | |||
A (Rhodopsin) | Chemokine | XCR1 | XCR1 | Human | Xcl1 | 1 | Peptide | 7.3 | 7.3 | Refs | |||||
A (Rhodopsin) | Galanin | GALR1 | GAL1 | Mouse | Galanin | 1 | Peptide | 9.8 | 9.8 | 9.3 | 9.8 | 10.3 | Refs | ||
A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Mouse | Peptide Yy | 5 | Peptide | 6.3 | 7.0 | 8.5 | Refs | ||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1B | 5-HT1B | Human | 5-Hydroxytryptamine | None | 1 | Small molecule | 7.4 | 8.1 | 8.1 | Refs | |||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT7R | 5-HT7 | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 8.1 | 8.9 | 9.6 | Refs | |||
A (Rhodopsin) | P2Y | P2RY2 | P2Y2 | Human | Utp | None | 1 | Small molecule | 8.1 | 8.1 | Refs | ||||
A (Rhodopsin) | Galanin | GALR3 | GAL3 | Human | Galanin | 2 | Peptide | 8.1 | 8.5 | 8.8 | Refs | ||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR2 | LPA2 | Human | Farnesyl Diphosphate | None | 2 | Small molecule | Refs | ||||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR4 | LPA4 | Mouse | Lpa | None | 1 | Small molecule | Refs | ||||||
A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Human | Srif-28 | 2 | Peptide | 8.4 | 9.3 | 10.2 | Refs | ||||
A (Rhodopsin) | Opioid | OPRM | μ | Human | Dynorphin A-(1-8) | 3 | Peptide | 8.4 | 8.4 | Refs | |||||
B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Pacap-27 | 2 | Peptide | 7.6 | 8.5 | 9.4 | Refs | ||||
A (Rhodopsin) | Orexin | OX1R | OX1 | Human | Orexin-A | 1 | Peptide | 6.5 | 8.4 | 10.2 | Refs | ||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT4R | 5-HT4 | Mouse | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.7 | 7.5 | 8.2 | Refs | |||
A (Rhodopsin) | Vasopressin and oxytocin | V2R | V2 | Human | Vasopressin | 1 | Peptide | 7.9 | 8.5 | 9.1 | Refs | ||||
B1 (Secretin) | Corticotropin-releasing factor | CRFR1 | CRF1 | Human | Corticotrophin-Releasing Hormone | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Adren | ADA2C | α2C-adren | Human | (-)-Adrenaline | None | 2 | Small molecule | 5.8 | 5.8 | Refs | ||||
A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Rat | Oxytocin | 2 | Peptide | 6.9 | 6.1 | 6.1 | Refs | ||||
A (Rhodopsin) | Vasopressin and oxytocin | V1BR | V1B | Human | Vasopressin | 1 | Peptide | 9.0 | 9.3 | 9.5 | Refs | ||||
C (Glutamate) | Metabotropic glutamate | GRM3 | mGlu3 | Human | L-Glutamic Acid | None | 1 | Small molecule | 5.3 | 5.4 | 5.4 | 6.4 | 6.4 | Refs | |
A (Rhodopsin) | Adren | ADA1D | α1D-adren | Human | (-)-Adrenaline | None | 1 | Small molecule | 7.2 | 7.2 | Refs | ||||
A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Rat | Pgf2Α | None | 3 | Small molecule | 6.1 | 6.1 | 9.1 | 9.3 | 9.5 | Refs | |
A (Rhodopsin) | Chemokine | CXCR6 | CXCR6 | Human | Cxcl16 | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT5A | 5-HT5A | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.0 | 6.3 | 6.6 | Refs | |||
A (Rhodopsin) | Free fatty acid | FFAR4 | FFA4 | Human | Linoleic Acid | None | 1 | Small molecule | 5.9 | 5.9 | Refs | ||||
A (Rhodopsin) | Tachykinin | NK1R | NK1 | Human | Neurokinin A | 2 | Peptide | 6.2 | 7.8 | 9.3 | Refs | ||||
A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Mouse | Tyramine | None | 2 | Small molecule | 6.9 | 7.1 | 7.2 | 6.4 | 6.4 | Refs | |
A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Rat | Pge2 | None | 1 | Small molecule | 7.3 | 7.7 | 7.7 | Refs | |||
A (Rhodopsin) | Somatostatin | SSR1 | SST1 | Human | Srif-14 | 2 | Peptide | 8.6 | 9.1 | 9.5 | Refs | ||||
A (Rhodopsin) | Free fatty acid | FFAR2 | FFA2 | Human | Acetic Acid | None | 2 | Small molecule | 3.1 | 3.9 | 4.6 | Refs | |||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR4 | S1P4 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.2 | 7.1 | 7.1 | Refs | |||
A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Pge2 | None | 1 | Small molecule | 7.3 | 7.7 | 7.7 | Refs | |||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT4R | 5-HT4 | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.7 | 7.5 | 8.2 | Refs | |||
A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Human | Cst-17 | 2 | Peptide | 8.5 | 9.4 | 10.2 | Refs | ||||
A (Rhodopsin) | Class A orphan | GPR34 | GPR34 | Human | Lysophosphatidylserine | Principal | 1 | Small molecule | 6.6 | 7.3 | 7.3 | Refs | |||
A (Rhodopsin) | Dopamine | DRD1 | D1 | Human | Noradrenaline | None | 3 | Small molecule | 4.3 | 4.3 | Refs | ||||
A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl14 | Peptide | |||||||||
B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Pacap-27 | 1 | Peptide | 10.0 | 10.1 | 10.1 | 8.5 | 8.7 | 8.8 | Refs | |
A (Rhodopsin) | Prostanoid | PD2R | DP1 | Human | Thromboxane A2 | 6 | Small molecule | ||||||||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl8 | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | CXCR1 | CXCR1 | Human | Cxcl8 | 1 | Peptide | 8.8 | 9.2 | 9.5 | Refs | ||||
A (Rhodopsin) | Prostanoid | PF2R | FP | Mouse | Pgf2Α | None | 1 | Small molecule | 7.9 | 8.2 | 8.5 | Refs | |||
A (Rhodopsin) | Galanin | GALR2 | GAL2 | Human | Spexin-1 | 3 | Peptide | 6.8 | 6.8 | Refs | |||||
A (Rhodopsin) | Opioid | OPRK | κ | Human | Dynorphin A-(1-8) | 6 | Peptide | 8.0 | 9.0 | 9.9 | Refs | ||||
A (Rhodopsin) | Histamine | HRH3 | H3 | Rat | Histamine | Principal | 1 | Small molecule | 7.1 | 7.5 | 7.8 | Refs | |||
A (Rhodopsin) | Free fatty acid | FFAR4 | FFA4 | Human | Α-Linolenic Acid | None | 3 | Small molecule | 5.1 | 5.1 | Refs | ||||
A (Rhodopsin) | P2Y | P2RY4 | P2Y4 | Rat | Atp | None | 2 | Small molecule | 5.7 | 5.4 | 5.4 | Refs | |||
A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Mouse | Bradykinin | 5 | Peptide | 5.1 | 5.2 | 5.3 | Refs | ||||
B1 (Secretin) | Calcitonin | CALCR | CT | Human | Calcitonin (Salmon) | None | 2 | Peptide | 7.6 | 9.4 | 11.1 | Refs | |||
B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Mouse | Corticotrophin-Releasing Hormone | 1 | Peptide | 7.8 | 7.8 | Refs | |||||
A (Rhodopsin) | Chemokine | CXCR6 | CXCR6 | Human | Cxcl16 | Principal | 1 | Peptide | Refs | ||||||
B1 (Secretin) | Glucagon receptor family | GLP2R | GLP-2 | Human | Glucagon-Like Peptide 2 | 4 | Peptide | Refs | |||||||
A (Rhodopsin) | P2Y | P2RY4 | P2Y4 | Human | Utp | None | 1 | Small molecule | 5.6 | 5.6 | Refs | ||||
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Human | Udp-Glucose | None | 1 | Small molecule | 7.6 | 7.6 | Refs | ||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | Human | Rfrp-3 | 2 | Peptide | 7.8 | 7.8 | Refs | |||||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl1 | 2 | Peptide | 8.4 | 9.1 | 9.7 | Refs | ||||
A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Rat | Pgd2 | None | 2 | Small molecule | 8.8 | 8.8 | 8.7 | 8.9 | 9.0 | Refs | |
B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Rat | Pacap-27 | 1 | Peptide | 10.0 | 10.1 | 10.1 | 8.5 | 8.7 | 8.8 | Refs | |
A (Rhodopsin) | Relaxin family peptide | RL3R2 | RXFP4 | Human | Insl5 | 3 | Peptide | 7.0 | 7.7 | 8.9 | 7.3 | 8.1 | 8.8 | Refs | |
A (Rhodopsin) | Gonadotrophin-releasing hormone | GNRHR | GnRH1 | Rat | Gnrh I | 1 | Peptide | 7.8 | 10.0 | 10.0 | 7.3 | 8.0 | 8.4 | Refs | |
A (Rhodopsin) | Prostanoid | PF2R | FP | Human | Pgf2Α | None | 1 | Small molecule | 7.9 | 8.2 | 8.5 | Refs | |||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl3 | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Mouse | Udp N-Acetyl-Glucosamine | None | 4 | Small molecule | 6.8 | 6.8 | Refs | ||||
B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Secretin | 4 | Peptide | ||||||||
C (Glutamate) | Calcium-sensing | CASR | CaS | Mouse | Ca2+ | None | 2 | Small molecule | Refs | ||||||
C (Glutamate) | Calcium-sensing | CASR | CaS | Human | L-Tryptophan | None | 1 | Small molecule | Refs | ||||||
A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Rat | Peptide Yy | 5 | Peptide | 6.3 | 7.0 | 8.5 | Refs | ||||
A (Rhodopsin) | Relaxin family peptide | RL3R1 | RXFP3 | Human | Relaxin | 2 | Peptide | 7.1 | 7.8 | 8.4 | Refs | ||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1D | 5-HT1D | Human | 5-Hydroxytryptamine | None | 1 | Small molecule | 8.0 | 8.5 | 9.0 | Refs | |||
A (Rhodopsin) | Galanin | GALR3 | GAL3 | Human | Spexin-1 | 1 | Peptide | 6.2 | 6.2 | Refs | |||||
A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Agouti-Related Protein | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Opioid | OPRK | κ | Human | Β-Endorphin | 9 | Peptide | ||||||||
A (Rhodopsin) | Complement peptide | C5AR1 | C5a1 | Human | C3a | 2 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide W-23 | 5 | Peptide | ||||||||
A (Rhodopsin) | Somatostatin | SSR1 | SST1 | Human | Srif-28 | 3 | Peptide | 8.6 | 9.0 | 9.4 | Refs | ||||
A (Rhodopsin) | Bombesin | NMBR | BB1 | Human | Neuromedin B | 1 | Peptide | 8.1 | 9.2 | 10.3 | Refs | ||||
A (Rhodopsin) | Ghrelin | GHSR | ghrelin | Human | Ghrelin | 1 | Peptide | 7.2 | 8.1 | 9.5 | 7.8 | 8.0 | 8.1 | Refs | |
A (Rhodopsin) | Melanocortin | MC4R | MC4 | Human | Γ-Msh | 3 | Peptide | ||||||||
A (Rhodopsin) | Urotensin | UR2R | UT | Human | Urotensin Ii-Related Peptide | 4 | Peptide | Refs | |||||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Cck-33 | 2 | Peptide | Refs | |||||||
C (Glutamate) | Metabotropic glutamate | GRM6 | mGlu6 | Human | L-Glutamic Acid | None | 2 | Small molecule | 4.8 | 5.0 | 5.2 | Refs | |||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl24 | 5 | Peptide | Refs | |||||||
A (Rhodopsin) | Bombesin | GRPR | BB2 | Human | Grp-(18-27) | 3 | Peptide | ||||||||
B1 (Secretin) | Glucagon receptor family | GLR | glucagon | Human | Glucagon | Principal | 1 | Peptide | 9.0 | 9.0 | Refs | ||||
A (Rhodopsin) | Prostanoid | PD2R | DP1 | Rat | Pgd2 | None | 2 | Small molecule | 7.8 | 8.5 | 9.2 | Refs | |||
A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Cck-33 | 2 | Peptide | ||||||||
A (Rhodopsin) | Relaxin family peptide | RXFP1 | RXFP1 | Human | Relaxin-3 | 3 | Peptide | 7.5 | 7.8 | 8.0 | Refs | ||||
A (Rhodopsin) | Complement peptide | C5AR2 | C5a2 | Human | C5a Des-Arg | 2 | Peptide | 8.6 | 8.6 | Refs | |||||
A (Rhodopsin) | Adren | ADRB1 | β1-adren | Human | (-)-Adrenaline | None | 3 | Small molecule | 5.4 | 5.7 | 6.0 | Refs | |||
A (Rhodopsin) | Formylpeptide | FPR3 | FPR3 | Human | F2l | 4 | Peptide | ||||||||
A (Rhodopsin) | Opioid | OPRK | κ | Mouse | Dynorphin A | 1 | Peptide | 10.0 | 10.2 | 10.3 | Refs | ||||
A (Rhodopsin) | Melanin-concentrating hormon | MCHR1 | MCH1 | Rat | Melanin-Concentrating Hormone | Principal | 1 | Peptide | 9.8 | 9.9 | 10.0 | Refs | |||
B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Rat | Pacap-38 | 2 | Peptide | 7.5 | 8.9 | 10.3 | 6.9 | 8.2 | 9.0 | Refs | |
A (Rhodopsin) | Melatonin | MTR1A | MT1 | Human | Melatonin | Principal | 1 | Small molecule | 9.1 | 9.4 | 9.7 | Refs | |||
A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Rat | Vasopressin | 1 | Peptide | 8.5 | 8.9 | 9.3 | Refs | ||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | Human | Neuropeptide Af | 3 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW2 | NPBW2 | Human | Neuropeptide B-29 | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Rat | Pge2 | None | 1 | Small molecule | 9.4 | 9.4 | 9.1 | 9.1 | Refs | ||
A (Rhodopsin) | Bombesin | GRPR | BB2 | Human | Gastrin-Releasing Peptide | 1 | Peptide | 6.3 | 7.3 | 8.2 | Refs | ||||
B1 (Secretin) | Glucagon receptor family | GIPR | GIP | Rat | Gastric Inhibitory Polypeptide | Principal | 1 | Peptide | Refs | ||||||
A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Human | Pge2 | None | 2 | Small molecule | 7.5 | 7.9 | 8.3 | Refs | |||
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Human | Pgf2Α | None | 2 | Small molecule | 8.4 | 8.4 | 7.4 | 7.4 | Refs | ||
A (Rhodopsin) | Dopamine | DRD1 | D1 | Human | 5-Hydroxytryptamine | None | 1 | Small molecule | 5.0 | 5.0 | Refs | ||||
A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Pgf2Α | None | 3 | Small molecule | 6.2 | 5.9 | 5.9 | Refs | |||
B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Phi | 4 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Cxcl9 | 5 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Mouse | Lte4 | None | 1 | Small molecule | 9.5 | 9.5 | Refs | ||||
A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Human | Β-Phenylethylamine | None | 3 | Small molecule | 6.2 | 6.6 | 7.0 | Refs | |||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR2 | LPA2 | Human | Farnesyl Monophosphate | None | 2 | Small molecule | Refs | ||||||
A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Human | Srif-14 | 3 | Peptide | 8.4 | 9.2 | 9.9 | Refs | ||||
A (Rhodopsin) | Tachykinin | NK2R | NK2 | Human | Substance P | 2 | Peptide | 5.9 | 6.4 | 6.9 | Refs | ||||
A (Rhodopsin) | Histamine | HRH4 | H4 | Human | Histamine | None | 1 | Small molecule | 7.8 | 7.2 | 7.2 | Refs | |||
B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Vip | 3 | Peptide | 7.3 | 8.3 | 9.3 | 7.8 | 8.4 | 8.8 | Refs | |
A (Rhodopsin) | Leukotriene | CLTR2 | CysLT2 | Human | Ltd4 | None | 2 | Small molecule | 6.8 | 7.6 | 8.6 | 7.3 | 7.7 | 8.1 | Refs |
A (Rhodopsin) | Vasopressin and oxytocin | V1AR | V1A | Human | Oxytocin | 2 | Peptide | 6.9 | 6.1 | 6.1 | Refs | ||||
A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Mouse | Srif-14 | 1 | Peptide | 8.7 | 9.4 | 10.0 | Refs | ||||
A (Rhodopsin) | Bile acid | GPBAR | GPBA | Human | Deoxycholic Acid | None | 2 | Small molecule | 6.2 | 6.2 | Refs | ||||
A (Rhodopsin) | Galanin | GALR3 | GAL3 | Human | Galanin-Like Peptide | 2 | Peptide | ||||||||
A (Rhodopsin) | Histamine | HRH3 | H3 | Human | Histamine | Principal | 1 | Small molecule | 7.1 | 7.5 | 7.8 | Refs | |||
A (Rhodopsin) | Adren | ADA1A | α1A-adren | Human | (-)-Adrenaline | None | 1 | Small molecule | 6.3 | 6.4 | 6.5 | Refs | |||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR3 | S1P3 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 8.4 | 8.6 | 8.6 | Refs | |||
A (Rhodopsin) | Chemokine | ACKR1 | ACKR1 | Human | Cxcl6 | Peptide | |||||||||
A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM2 | M2 | Human | Acetylcholine | Principal | 1 | Small molecule | 4.3 | 5.4 | 6.5 | Refs | |||
B1 (Secretin) | Calcitonin | CALCR | CT | Human | Adrenomedullin | 5 | Peptide | 6.7 | 7.2 | 7.7 | Refs | ||||
C (Glutamate) | Metabotropic glutamate | GRM4 | mGlu4 | Human | L-Serine-O-Phosphate | None | 1 | Small molecule | 5.9 | 5.9 | Refs | ||||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl3 | 3 | Peptide | ||||||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR5 | LPA5 | Human | N-Arachidonoylglycine | None | 4 | Small molecule | 4.3 | 4.3 | Refs | ||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT5A | 5-HT5A | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.0 | 6.3 | 6.6 | Refs | |||
A (Rhodopsin) | Motilin | MTLR | motilin | Human | Motilin | Principal | 1 | Peptide | 8.4 | 8.6 | 8.7 | Refs | |||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl2 | 8 | Peptide | ||||||||
A (Rhodopsin) | Opioid | OPRK | κ | Rat | Β-Neoendorphin | 4 | Peptide | 9.1 | 9.1 | Refs | |||||
A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Mouse | Β-Phenylethylamine | None | 3 | Small molecule | 6.2 | 6.6 | 7.0 | Refs | |||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Des-Br-Neuropeptide B-29 | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Gonadotrophin-releasing hormone | GNRHR | GnRH1 | Mouse | Gnrh I | 1 | Peptide | 7.8 | 10.0 | 10.0 | 7.3 | 8.0 | 8.4 | Refs | |
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT7R | 5-HT7 | Mouse | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 8.1 | 8.9 | 9.6 | Refs | |||
A (Rhodopsin) | Tachykinin | NK1R | NK1 | Human | Substance P | 1 | Peptide | 8.5 | 9.4 | 10.3 | Refs | ||||
A (Rhodopsin) | Melanin-concentrating hormon | MCHR1 | MCH1 | Human | Melanin-Concentrating Hormone | Principal | 1 | Peptide | 9.8 | 9.9 | 10.0 | Refs | |||
A (Rhodopsin) | Leukotriene | LT4R1 | BLT1 | Human | 12r-Hete | None | 3 | Small molecule | 7.5 | 7.5 | Refs | ||||
A (Rhodopsin) | Urotensin | UR2R | UT | Rat | Urotensin-Ii | 1 | Peptide | 8.8 | 8.8 | Refs | |||||
A (Rhodopsin) | Chemokine | CCR7 | CCR7 | Human | Ccl21 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Human | Srif-28 | 1 | Peptide | 9.8 | 9.9 | 9.9 | Refs | ||||
A (Rhodopsin) | Prostanoid | PF2R | FP | Human | Pgd2 | None | 2 | Small molecule | 7.7 | 7.7 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl13 | 7 | Peptide | ||||||||
A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Β-Msh | 2 | Peptide | ||||||||
A (Rhodopsin) | Adren | ADA1D | α1D-adren | Rat | (-)-Adrenaline | None | 1 | Small molecule | 7.2 | 7.2 | Refs | ||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Rfrp-3 | 1 | Peptide | 9.2 | 9.3 | 9.3 | Refs | ||||
A (Rhodopsin) | Somatostatin | SSR4 | SST4 | Human | Srif-28 | 3 | Peptide | 8.1 | 8.7 | 9.2 | Refs | ||||
A (Rhodopsin) | Vasopressin and oxytocin | V1BR | V1B | Human | Oxytocin | 2 | Peptide | 5.7 | 6.4 | 7.0 | Refs | ||||
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Pacap-27 | 2 | Peptide | 7.6 | 8.6 | 9.9 | 8.9 | 8.9 | Refs | ||
A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Rat | Srif-14 | 1 | Peptide | 8.7 | 9.4 | 10.0 | Refs | ||||
A (Rhodopsin) | Chemokine | ACKR1 | ACKR1 | Human | Ccl14 | Peptide | |||||||||
A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Mouse | Pge2 | None | 2 | Small molecule | 7.5 | 7.9 | 8.3 | Refs | |||
B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Rat | Corticotrophin-Releasing Hormone | 1 | Peptide | 7.8 | 7.8 | Refs | |||||
A (Rhodopsin) | Opioid | OPRK | κ | Mouse | Dynorphin A-(1-8) | 6 | Peptide | 8.0 | 9.0 | 9.9 | Refs | ||||
A (Rhodopsin) | Bombesin | GRPR | BB2 | Mouse | Neuromedin B | 2 | Peptide | 6.4 | 6.6 | 6.6 | Refs | ||||
B2 (Adhesion) | ADGRL | AGRL1 | ADGRL1 | Human | Lasso D | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Prostanoid | PD2R | DP1 | Human | Pgj2 | None | 1 | Small molecule | 9.0 | 9.0 | Refs | ||||
A (Rhodopsin) | Leukotriene | OXER1 | OXE | Human | 5-Oxo-Ete | None | 1 | Small molecule | 8.3 | 8.4 | 8.5 | Refs | |||
A (Rhodopsin) | Opioid | OPRK | κ | Rat | [Leu]Enkephalin | 8 | Peptide | 6.0 | 6.0 | Refs | |||||
A (Rhodopsin) | Oxoglutarate | OXGR1 | xoglutarate | Human | Α-Ketoglutaric Acid | Principal | 1 | Small molecule | 3.3 | 3.9 | 4.5 | Refs | |||
A (Rhodopsin) | Prostanoid | PD2R | DP1 | Human | Pgf2Α | None | 5 | Small molecule | 6.1 | 6.3 | 6.4 | Refs | |||
A (Rhodopsin) | Histamine | HRH4 | H4 | Rat | Histamine | None | 1 | Small molecule | 7.8 | 7.2 | 7.2 | Refs | |||
A (Rhodopsin) | Tachykinin | NK3R | NK3 | Mouse | Substance P | 3 | Peptide | 5.0 | 5.5 | 6.0 | Refs | ||||
A (Rhodopsin) | Apelin | APJ | apelin | Human | Elabela/Toddler-21 | 2 | Peptide | ||||||||
A (Rhodopsin) | Opioid | OPRM | μ | Human | Endomorphin-1 | 4 | Peptide | 8.3 | 8.3 | Refs | |||||
A (Rhodopsin) | Class A orphan | GPR87 | GPR87 | Human | Lpa | Principal | 1 | Small molecule | 7.4 | 7.4 | Refs | ||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2C | 5-HT2C | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.8 | 7.7 | 8.6 | Refs | |||
A (Rhodopsin) | Galanin | GALR3 | GAL3 | Human | Galanin-Like Peptide | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl6 | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR5 | LPA5 | Human | Farnesyl Diphosphate | None | 2 | Small molecule | 5.8 | 6.2 | 6.5 | Refs | |||
A (Rhodopsin) | Chemokine | CXCR5 | CXCR5 | Human | Cxcl13 | Principal | 1 | Peptide | Refs | ||||||
A (Rhodopsin) | Adenosine | AA2BR | A2B | Rat | Adenosine | Principal | 1 | Small molecule | 5.3 | 5.3 | Refs | ||||
A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Rat | Β-Phenylethylamine | None | 3 | Small molecule | 6.2 | 6.6 | 7.0 | Refs | |||
A (Rhodopsin) | Kisspeptin | KISSR | kisspeptin | Human | Kisspeptin-14 | 3 | Peptide | 8.8 | 8.8 | Refs | |||||
A (Rhodopsin) | Adren | ADA1D | α1D-adren | Human | (-)-Noradrenaline | None | 2 | Small molecule | 6.3 | 6.3 | Refs | ||||
F (Frizzled) | Frizzled | FZD1 | FZD1 | Human | Wnt-2 | Peptide | |||||||||
A (Rhodopsin) | Leukotriene | LT4R2 | BLT2 | Human | 12-Hydroxyheptadecatrienoic Acid | None | 1 | Small molecule | 7.7 | 7.7 | Refs | ||||
A (Rhodopsin) | Prostanoid | TA2R | TP | Human | Pgf2Α | None | 1 | Small molecule | 5.1 | 5.1 | Refs | ||||
B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Rat | Phv | 4 | Peptide | Refs | |||||||
A (Rhodopsin) | P2Y | P2RY6 | P2Y6 | Human | Adp | None | 3 | Small molecule | 4.5 | 4.5 | Refs | ||||
A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Rat | Pge1 | None | 1 | Small molecule | 8.0 | 8.0 | Refs | ||||
A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Mouse | Srif-14 | 3 | Peptide | 8.4 | 9.2 | 9.9 | Refs | ||||
A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Human | Pgf2Α | None | 3 | Small molecule | 5.2 | 5.6 | 6.0 | Refs | |||
A (Rhodopsin) | Vasopressin and oxytocin | OXYR | OT | Rat | Oxytocin | 1 | Peptide | 8.2 | 8.9 | 9.6 | Refs | ||||
A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM4 | M4 | Human | Acetylcholine | Principal | 1 | Small molecule | 4.5 | 5.1 | 5.6 | Refs | |||
B1 (Secretin) | Calcitonin | CALCR | CT | Human | Β-Cgrp | 7 | Peptide | ||||||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT7R | 5-HT7 | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 8.1 | 8.9 | 9.6 | Refs | |||
A (Rhodopsin) | Free fatty acid | FFAR2 | FFA2 | Human | Propanoic Acid | None | 1 | Small molecule | 3.0 | 4.0 | 4.9 | Refs | |||
A (Rhodopsin) | Glycoprotein hormone | LSHR | LH | Human | Hcg | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Neuromedin U | NMUR1 | NMU1 | Human | Neuromedin S-33 | 1 | Peptide | 10.2 | 10.2 | Refs | |||||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl11 | 6 | Peptide | Refs | |||||||
B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Mouse | Urocortin 2 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Annexin I | 9 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Mouse | Pge1 | None | 1 | Small molecule | 8.0 | 8.0 | Refs | ||||
A (Rhodopsin) | Relaxin family peptide | RL3R2 | RXFP4 | Mouse | Insl5 | 2 | Peptide | 7.8 | 8.6 | 9.4 | 8.5 | 8.7 | 8.8 | Refs | |
A (Rhodopsin) | Neuromedin U | NMUR2 | NMU2 | Human | Neuromedin S-36 | 3 | Peptide | ||||||||
A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Human | Neurotensin | 1 | Peptide | 8.8 | 8.8 | Refs | |||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl13 | 5 | Peptide | Refs | |||||||
A (Rhodopsin) | Gonadotrophin-releasing hormone | GNRHR | GnRH1 | Human | Gnrh I | 1 | Peptide | 7.8 | 10.0 | 10.0 | 7.3 | 8.0 | 8.4 | Refs | |
A (Rhodopsin) | Prokineticin | PKR1 | PKR1 | Human | Prokineticin-2 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Cck-58 | 2 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Ccl19 | 8 | Peptide | 5.9 | 5.9 | Refs | |||||
A (Rhodopsin) | Hydroxycarboxylic acid | HCAR1 | HCA1 | Mouse | L-Lactic Acid | Principal | 1 | Small molecule | 1.3 | 2.1 | 2.9 | Refs | |||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR2 | S1P2 | Mouse | Sphingosine 1-Phosphate | None | 1 | Small molecule | 8.1 | 8.7 | 8.7 | Refs | |||
A (Rhodopsin) | Neuropeptide Y | NPY5R | Y5 | Human | Peptide Yy | 2 | Peptide | 9.0 | 9.0 | Refs | |||||
A (Rhodopsin) | Melanocortin | MSHR | MC1 | Human | Β-Msh | 2 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl28 | 5 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PD2R | DP1 | Human | Pge2 | None | 4 | Small molecule | 6.5 | 6.8 | 7.0 | Refs | |||
A (Rhodopsin) | Adren | ADRB1 | β1-adren | Human | (-)-Noradrenaline | None | 2 | Small molecule | 5.5 | 5.8 | 6.0 | Refs | |||
A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Rat | Pgd2 | None | 4 | Small molecule | 5.2 | 5.2 | Refs | ||||
A (Rhodopsin) | Relaxin family peptide | RL3R1 | RXFP3 | Human | Relaxin-3 | 1 | Peptide | 8.3 | 9.1 | 9.9 | 7.8 | 8.4 | 8.9 | Refs | |
A (Rhodopsin) | Free fatty acid | FFAR1 | FFA1 | Human | Α-Linolenic Acid | None | 2 | Small molecule | 4.6 | 5.2 | 5.7 | Refs | |||
A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Pge2 | None | 3 | Small molecule | 6.1 | 6.1 | 8.5 | 8.6 | 8.7 | Refs | |
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR1 | S1P1 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.1 | 8.7 | 9.5 | Refs | |||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1F | 5-HT1F | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 7.7 | 7.9 | 8.0 | Refs | |||
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Mouse | Pgf2Α | None | 2 | Small molecule | 8.4 | 8.4 | 7.4 | 7.4 | Refs | ||
A (Rhodopsin) | Proteinase-activated | PAR1 | PAR1 | Human | Thrombin | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Hydroxycarboxylic acid | HCAR1 | HCA1 | Human | L-Lactic Acid | Principal | 1 | Small molecule | 1.3 | 2.1 | 2.9 | Refs | |||
A (Rhodopsin) | Opioid | OPRD | δ | Human | Endomorphin-1 | 6 | Peptide | 6.1 | 6.1 | Refs | |||||
A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Acth | 2 | Peptide | ||||||||
A (Rhodopsin) | Adren | ADRB3 | β3-adren | Rat | (-)-Noradrenaline | None | 2 | Small molecule | 4.7 | 4.2 | 4.2 | Refs | |||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT5A | 5-HT5A | Mouse | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.0 | 6.3 | 6.6 | Refs | |||
A (Rhodopsin) | Glycoprotein hormone | FSHR | FSH | Human | Fsh | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Gastrin-17 | 2 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl11 | 8 | Peptide | ||||||||
A (Rhodopsin) | Adren | ADRB3 | β3-adren | Human | (&Plusmn;)-Adrenaline | None | 1 | Small molecule | 3.9 | 5.3 | 5.3 | Refs | |||
A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Rat | Srif-28 | 3 | Peptide | 8.1 | 9.0 | 9.9 | Refs | ||||
A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Mouse | Pge1 | None | 2 | Small molecule | 7.0 | 7.0 | Refs | ||||
B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Pacap-38 | 1 | Peptide | 7.7 | 8.5 | 9.3 | Refs | ||||
B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Mouse | Urocortin 1 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Human | Srif-28 | 3 | Peptide | 8.1 | 9.0 | 9.9 | Refs | ||||
A (Rhodopsin) | Kisspeptin | KISSR | kisspeptin | Human | Kisspeptin-10 | 5 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Prrp-31 | 3 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Human | Udp-Glucose | None | 6 | Small molecule | 7.1 | 7.2 | 7.3 | Refs | |||
A (Rhodopsin) | Opioid | OPRD | δ | Human | Dynorphin A-(1-8) | 2 | Peptide | 8.4 | 8.4 | Refs | |||||
A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Mouse | Pge2 | None | 3 | Small molecule | 6.1 | 6.1 | 8.5 | 8.6 | 8.7 | Refs | |
A (Rhodopsin) | Opioid | OPRK | κ | Human | Β-Endorphin | 7 | Peptide | 6.3 | 7.1 | 7.9 | Refs | ||||
A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Human | Cortistatin-14 | 2 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide W-30 | 5 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Human | Pgi2 | 4 | Small molecule | ||||||||
A (Rhodopsin) | Free fatty acid | FFAR1 | FFA1 | Human | Oleic Acid | None | 3 | Small molecule | 3.9 | 4.8 | 5.7 | Refs | |||
A (Rhodopsin) | Hydroxycarboxylic acid | HCAR2 | HCA2 | Human | Β-D-Hydroxybutyric Acid | None | 1 | Small molecule | 3.5 | 3.5 | Refs | ||||
A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Mouse | Srif-28 | 3 | Peptide | 8.1 | 9.0 | 9.9 | Refs | ||||
A (Rhodopsin) | Adren | ADA2B | α2B-adren | Human | (-)-Noradrenaline | None | 1 | Small molecule | 5.4 | 5.7 | 6.0 | Refs | |||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Cxcl10 | 5 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Mouse | Udp-Galactose | None | 5 | Small molecule | 6.0 | 7.2 | 7.2 | Refs | |||
A (Rhodopsin) | Chemerin | CML1 | hemerin | Human | Epa | 2 | Small molecule | ||||||||
A (Rhodopsin) | Glycoprotein hormone | FSHR | FSH | Human | Fsh | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Pge1 | None | 1 | Small molecule | 9.5 | 9.5 | 8.7 | 8.7 | Refs | ||
B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Ghrh | 4 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl5 | 2 | Peptide | 8.5 | 8.9 | 9.3 | Refs | ||||
A (Rhodopsin) | Somatostatin | SSR4 | SST4 | Human | Cst-17 | 1 | Peptide | 8.5 | 9.1 | 9.6 | Refs | ||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT6R | 5-HT6 | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.8 | 7.2 | 7.5 | Refs | |||
A (Rhodopsin) | Opioid | OPRK | κ | Human | Α-Neoendorphin | 3 | Peptide | 8.9 | 9.5 | 10.0 | Refs | ||||
A (Rhodopsin) | Neuropeptide Y | NPY2R | Y2 | Human | Neuropeptide Y-(3-36) | 5 | Peptide | ||||||||
A (Rhodopsin) | Orexin | OX1R | OX1 | Human | Orexin-B | 3 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GPR35 | GPR35 | Mouse | Kynurenic Acid | None | 2 | Small molecule | 3.9 | 5.0 | 5.0 | Refs | |||
A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Human | Tyramine | None | 2 | Small molecule | 6.9 | 7.1 | 7.2 | 6.4 | 6.4 | Refs | |
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Rat | Udp N-Acetyl-Glucosamine | None | 4 | Small molecule | 6.8 | 6.8 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl5 | 2 | Peptide | 9.2 | 9.5 | 9.7 | Refs | ||||
A (Rhodopsin) | Apelin | APJ | apelin | Human | Elabela/Toddler-11 | 2 | Peptide | ||||||||
B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Human | Tip39 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Prolactin-releasing peptide | PRLHR | PrRP | Human | Prrp-31 | 2 | Peptide | 9.0 | 9.1 | 9.2 | Refs | ||||
B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Human | Urocortin 2 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Rat | Srif-28 | 2 | Peptide | 8.4 | 9.3 | 10.2 | Refs | ||||
C (Glutamate) | Metabotropic glutamate | GRM8 | mGlu8 | Human | L-Serine-O-Phosphate | None | 2 | Small molecule | Refs | ||||||
A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Thromboxane A2 | 4 | Small molecule | ||||||||
A (Rhodopsin) | Melanocortin | MC3R | MC3 | Human | Β-Msh | 3 | Peptide | ||||||||
A (Rhodopsin) | Formylpeptide | FPR1 | FPR1 | Human | Spinorphin | None | 2 | Peptide | Refs | ||||||
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Human | Pge2 | None | 1 | Small molecule | 9.4 | 9.4 | 9.1 | 9.1 | Refs | ||
A (Rhodopsin) | Vasopressin and oxytocin | OXYR | OT | Human | Oxytocin | 1 | Peptide | 8.2 | 8.9 | 9.6 | Refs | ||||
C (Glutamate) | Metabotropic glutamate | GRM4 | mGlu4 | Human | L-Glutamic Acid | None | 2 | Small molecule | 4.7 | 5.1 | 5.5 | 4.9 | 5.2 | 5.5 | Refs |
A (Rhodopsin) | Neuromedin U | NMUR1 | NMU1 | Human | Neuromedin U-25 | 2 | Peptide | 8.4 | 8.9 | 9.4 | 9.5 | 9.5 | Refs | ||
A (Rhodopsin) | Adren | ADRB2 | β2-adren | Human | (-)-Noradrenaline | None | 3 | Small molecule | 4.6 | 4.7 | 4.8 | Refs | |||
A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Mouse | Srif-14 | 1 | Peptide | 9.0 | 9.1 | 9.1 | 8.9 | 9.7 | 10.5 | Refs | |
A (Rhodopsin) | P2Y | P2Y12 | P2Y12 | Human | Atp | 2 | Small molecule | ||||||||
B1 (Secretin) | Parathyroid hormone | PTH1R | PTH1 | Human | Pth | 3 | Peptide | ||||||||
B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Rat | Vip | 3 | Peptide | 7.3 | 8.3 | 9.3 | 7.8 | 8.4 | 8.8 | Refs | |
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Ccl7 | 6 | Peptide | 6.6 | 6.6 | Refs | |||||
A (Rhodopsin) | Chemokine | CCR7 | CCR7 | Mouse | Ccl19 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Class A orphan | Q33BM1 | GPR35 | Rat | Kynurenic Acid | None | 2 | Small molecule | 3.9 | 5.0 | 5.0 | Refs | |||
A (Rhodopsin) | Opioid | OPRD | δ | Human | [Met]Enkephalin | 7 | Peptide | Refs | |||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW2 | NPBW2 | Human | Neuropeptide B-29 | 5 | Peptide | ||||||||
A (Rhodopsin) | Angiotensin | AGTR2 | AT2 | Human | Angiotensin-(1-7) | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Neuropeptide Y | NPY1R | Y1 | Rat | Peptide Yy | 2 | Peptide | 10.2 | 10.2 | Refs | |||||
A (Rhodopsin) | Hydroxycarboxylic acid | HCAR2 | HCA2 | Mouse | Β-D-Hydroxybutyric Acid | None | 1 | Small molecule | 3.5 | 3.5 | Refs | ||||
A (Rhodopsin) | Leukotriene | LT4R1 | BLT1 | Human | Ltb4 | None | 1 | Small molecule | 9.4 | 9.4 | |||||
A (Rhodopsin) | Tachykinin | NK3R | NK3 | Human | Neurokinin B | 1 | Peptide | 8.4 | 8.4 | 7.7 | 8.5 | 9.2 | Refs | ||
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Phi | 4 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PD2R | DP1 | Human | Pgd2 | None | 2 | Small molecule | 7.8 | 8.5 | 9.2 | Refs | |||
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Rat | Pge1 | None | 1 | Small molecule | 9.4 | 9.4 | 9.0 | 9.0 | Refs | ||
A (Rhodopsin) | Melanocortin | MSHR | MC1 | Human | Acth | 1 | Peptide | 8.6 | 8.6 | Refs | |||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Cxcl11 | 5 | Peptide | ||||||||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR5 | S1P5 | Mouse | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.4 | 8.2 | 8.9 | Refs | |||
A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl13 | Peptide | |||||||||
A (Rhodopsin) | Bombesin | GRPR | BB2 | Human | Neuromedin B | 2 | Peptide | 6.4 | 6.6 | 6.6 | Refs | ||||
A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM3 | M3 | Rat | Acetylcholine | Principal | 1 | Small molecule | 4.5 | 5.0 | 5.4 | Refs | |||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR3 | LPA3 | Mouse | Lpa | None | 1 | Small molecule | 6.6 | 6.6 | Refs | ||||
A (Rhodopsin) | Adren | ADA2A | α2A-adren | Human | (-)-Adrenaline | None | 1 | Small molecule | 5.8 | 6.6 | 7.4 | Refs | |||
A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Human | Peptide Yy | 5 | Peptide | 6.3 | 7.0 | 8.5 | Refs | ||||
B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Human | Urocortin 1 | 2 | Peptide | Refs | |||||||
B1 (Secretin) | Calcitonin | CALCR | CT | Human | Α-Cgrp | 4 | Peptide | 6.2 | 7.3 | 8.4 | Refs | ||||
A (Rhodopsin) | Chemokine | CCRL2 | CCRL2 | Human | Ccl19 | 2 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Mouse | Pgf2Α | None | 3 | Small molecule | 6.2 | 5.9 | 5.9 | Refs | |||
A (Rhodopsin) | Neuromedin U | NMUR2 | NMU2 | Human | Neuromedin U-25 | 2 | Peptide | 8.4 | 8.9 | 9.4 | 9.6 | 9.6 | Refs | ||
A (Rhodopsin) | Somatostatin | SSR4 | SST4 | Rat | Srif-14 | 2 | Peptide | 8.4 | 8.9 | 9.3 | Refs | ||||
A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Human | Large Neuromedin N | 3 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Mouse | Pge1 | None | 1 | Small molecule | 9.5 | 9.5 | 8.7 | 8.7 | Refs | ||
A (Rhodopsin) | Opioid | OPRK | κ | Rat | Dynorphin B | 5 | Peptide | 8.1 | 9.0 | 9.9 | Refs | ||||
A (Rhodopsin) | Angiotensin | AGTR2 | AT2 | Human | Angiotensin Iii | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Ccl13 | 4 | Peptide | 7.2 | 7.2 | Refs | |||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Neuropeptide Sf | 3 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PF2R | FP | Human | Pge2 | None | 3 | Small molecule | 6.4 | 6.7 | 6.9 | Refs | |||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl11 | 8 | Peptide | ||||||||
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Human | Udp N-Acetyl-Glucosamine | None | 4 | Small molecule | |||||||
A (Rhodopsin) | Melanocortin | ACTHR | MC2 | Human | Acth | Principal | 1 | Peptide | Refs | ||||||
A (Rhodopsin) | Class A orphan | GPR6 | GPR6 | Mouse | Sphingosine 1-Phosphate | Principal | 1 | Small molecule | 7.3 | 7.5 | 7.7 | Refs | |||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Neuropeptide Sf | 3 | Peptide | ||||||||
A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Rat | Neurotensin | 1 | Peptide | 8.2 | 9.1 | 10.0 | Refs | ||||
A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Cck-8 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Complement peptide | C3AR | C3a | Human | C5a | 2 | Peptide | ||||||||
A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Rat | Cck-8 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Prostanoid | PI2R | IP | Human | Pgi2 | None | 1 | Small molecule | 7.8 | 7.8 | Refs | ||||
A (Rhodopsin) | Opioid | OPRK | κ | Human | [Leu]Enkephalin | 8 | Peptide | 6.0 | 6.0 | Refs | |||||
A (Rhodopsin) | GPR18, GPR55 and GPR119 | GP119 | GPR119 | Human | N-Palmitoylethanolamine | None | 2 | Small molecule | |||||||
A (Rhodopsin) | Free fatty acid | FFAR3 | FFA3 | Human | Butyric Acid | None | 2 | Small molecule | 3.8 | 4.4 | 4.9 | Refs | |||
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Rat | Udp-Galactose | None | 1 | Small molecule | 7.6 | 7.6 | Refs | ||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1A | 5-HT1A | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 9.1 | 9.4 | 9.7 | Refs | |||
A (Rhodopsin) | Angiotensin | AGTR1 | AT1 | Human | Angiotensin A | 1 | Peptide | 8.2 | 8.2 | 8.8 | 8.8 | Refs | |||
B1 (Secretin) | Glucagon receptor family | GLP2R | GLP-2 | Human | Glucagon-Like Peptide 2 | 4 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide Y | NPY2R | Y2 | Human | Pancreatic Polypeptide | 5 | Peptide | ||||||||
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Pacap-38 | 3 | Peptide | 7.4 | 8.6 | 9.7 | 8.2 | 8.2 | Refs | ||
A (Rhodopsin) | Adren | ADA1B | α1B-adren | Human | (-)-Adrenaline | None | 1 | Small molecule | 6.5 | 6.5 | Refs | ||||
A (Rhodopsin) | Chemerin | CML1 | hemerin | Human | Resolvin E1 | None | 2 | Small molecule | Refs | ||||||
A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Rat | Pgf2Α | None | 3 | Small molecule | 6.2 | 5.9 | 5.9 | Refs | |||
A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Human | Pgd2 | None | 2 | Small molecule | 7.6 | 8.1 | 8.6 | Refs | |||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl14 | 7 | Peptide | 7.2 | 7.2 | Refs | |||||
A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Mouse | Srif-28 | 1 | Peptide | 9.8 | 9.9 | 9.9 | Refs | ||||
A (Rhodopsin) | Leukotriene | OXER1 | OXE | Human | 5-Oxo-15-Hete | None | 3 | Small molecule | 7.7 | 7.7 | Refs | ||||
A (Rhodopsin) | Dopamine | DRD4 | D4 | Human | Dopamine | Principal | 1 | Small molecule | 7.4 | 7.4 | Refs | ||||
A (Rhodopsin) | Neuropeptide Y | NPY1R | Y1 | Rat | Neuropeptide Y | 1 | Peptide | 10.5 | 10.5 | Refs | |||||
A (Rhodopsin) | Cannabinoid | CNR1 | CB1 | Human | Anandamide | None | 2 | Small molecule | 6.3 | 6.7 | 7.0 | Refs | |||
A (Rhodopsin) | Apelin | APJ | apelin | Human | Apelin-13 | 2 | Peptide | Refs | |||||||
B1 (Secretin) | Glucagon receptor family | GLP1R | GLP-1 | Human | Glucagon-Like Peptide 1-(7-37) | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | CXCR4 | CXCR4 | Human | Cxcl12Α | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Dopamine | DRD2 | D2 | Rat | Dopamine | Principal | 1 | Small molecule | 5.3 | 5.9 | 6.4 | Refs | |||
A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Rat | Srif-28 | 1 | Peptide | 9.8 | 9.9 | 9.9 | Refs | ||||
A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Rat | Tyramine | None | 2 | Small molecule | 6.9 | 7.1 | 7.2 | 6.4 | 6.4 | Refs | |
B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Human | Tip39 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Adren | ADA1A | α1A-adren | Human | (-)-Noradrenaline | None | 2 | Small molecule | 5.8 | 6.1 | 6.4 | Refs | |||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl7 | 3 | Peptide | 8.1 | 8.1 | Refs | |||||
A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Rat | 3-Iodothyronamine | None | 1 | Small molecule | 7.5 | 7.7 | 7.9 | Refs | |||
A (Rhodopsin) | Apelin | APJ | apelin | Human | [Pyr1]Apelin-13 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemerin | CML1 | hemerin | Human | Chemerin | 1 | Peptide | 7.6 | 8.0 | 8.5 | Refs | ||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2B | 5-HT2B | Rat | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 7.9 | 8.2 | 8.4 | Refs | |||
A (Rhodopsin) | GPR18, GPR55 and GPR119 | GPR18 | GPR18 | Human | N-Arachidonoylglycine | Principal | 1 | Small molecule | 7.3 | 7.5 | 7.7 | Refs | |||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl8 | 3 | Peptide | 9.3 | 9.3 | Refs | |||||
A (Rhodopsin) | Free fatty acid | FFAR3 | FFA3 | Human | Propanoic Acid | None | 1 | Small molecule | 3.9 | 4.8 | 5.7 | Refs | |||
C (Glutamate) | Metabotropic glutamate | GRM2 | mGlu2 | Rat | L-Glutamic Acid | Principal | 1 | Small molecule | 4.7 | 5.1 | 5.4 | 5.4 | 4.9 | 4.9 | Refs |
A (Rhodopsin) | Chemokine | CXCR6 | CXCR6 | Human | Cxcl16 | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Neuropeptide Af | 3 | Peptide | ||||||||
B1 (Secretin) | Calcitonin | CALCR | CT | Human | Α-Cgrp | 7 | Peptide | ||||||||
A (Rhodopsin) | Opioid | OPRK | κ | Human | Dynorphin B | 5 | Peptide | 8.1 | 9.0 | 9.9 | Refs | ||||
A (Rhodopsin) | Glycoprotein hormone | TSHR | TSH | Human | Tsh | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Lxa4 | None | 1 | Small molecule | 12.0 | 12.0 | Refs | ||||
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Rat | Udp-Glucuronic Acid | None | 3 | Small molecule | 7.0 | 7.0 | Refs | ||||
A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Human | Neurotensin | 1 | Peptide | 8.2 | 9.1 | 10.0 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR6 | CCR6 | Human | Ccl20 | 1 | Peptide | Refs | |||||||
C (Glutamate) | Calcium-sensing | CASR | CaS | Human | Ca2+ | None | 2 | Small molecule | Refs | ||||||
A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Rat | Neuropeptide Y | 4 | Peptide | 6.4 | 7.2 | 8.8 | Refs | ||||
A (Rhodopsin) | Complement peptide | C5AR1 | C5a1 | Human | C5a | 1 | Peptide | 8.0 | 8.5 | 9.0 | Refs | ||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2A | 5-HT2A | Human | 5-Hydroxytryptamine | None | 2 | Small molecule | 6.0 | 6.3 | 6.5 | Refs | |||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR4 | LPA4 | Human | Farnesyl Diphosphate | None | 2 | Small molecule | Refs | ||||||
A (Rhodopsin) | Opioid | OPRM | μ | Human | Β-Endorphin | 6 | Peptide | ||||||||
A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Human | Cst-17 | 2 | Peptide | 8.8 | 9.1 | 9.3 | Refs | ||||
A (Rhodopsin) | P2Y | P2RY2 | P2Y2 | Human | Atp | None | 2 | Small molecule | 6.6 | 6.9 | 7.1 | Refs | |||
A (Rhodopsin) | Class A orphan | LGR5 | LGR5 | Human | R-Spondin-4 | 4 | Peptide | 9.4 | 9.4 | Refs | |||||
A (Rhodopsin) | Peptide P518 | QRFPR | QRFP | Mouse | Qrfp26 | 1 | Peptide | 8.2 | 8.2 | Refs | |||||
A (Rhodopsin) | Orexin | OX1R | OX1 | Human | Orexin-B | 2 | Peptide | 5.8 | 7.5 | 9.2 | Refs | ||||
A (Rhodopsin) | Bradykinin | BKRB2 | B2 | Human | [Des-Arg9]Bradykinin | 2 | Peptide | Refs | |||||||
B1 (Secretin) | Glucagon receptor family | SCTR | secretin | Human | Vip | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Adren | ADRB2 | β2-adren | Human | (-)-Adrenaline | None | 1 | Small molecule | 6.0 | 6.1 | 6.2 | Refs | |||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl4 | 5 | Peptide | 7.1 | 7.5 | 7.8 | Refs | ||||
B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Rat | Tip39 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | ACKR1 | ACKR1 | Human | Ccl5 | Peptide | |||||||||
A (Rhodopsin) | Histamine | HRH4 | H4 | Mouse | Histamine | None | 1 | Small molecule | 7.8 | 7.2 | 7.2 | Refs | |||
C (Glutamate) | Class C Orphan | GPC6A | GPRC6 | Human | L-Ornithine | None | 2 | Small molecule | 4.0 | 4.0 | Refs | ||||
A (Rhodopsin) | Class A orphan | GP183 | GPR183 | Human | 7Α,25-Dihydroxycholesterol | None | 1 | Small molecule | 8.1 | 9.0 | 9.9 | Refs | |||
A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Human | Pgj2 | None | 1 | Small molecule | 8.2 | 8.2 | Refs | ||||
A (Rhodopsin) | Vasopressin and oxytocin | V2R | V2 | Human | Oxytocin | 2 | Peptide | 5.4 | 6.1 | 6.8 | Refs | ||||
B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Rat | Urocortin 3 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Human | Neuropeptide Y | 4 | Peptide | 6.4 | 7.2 | 8.8 | Refs | ||||
A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Rat | Pgf2Α | None | 3 | Small molecule | 5.2 | 5.6 | 6.0 | Refs | |||
A (Rhodopsin) | Melanin-concentrating hormon | MCHR2 | MCH2 | Human | Melanin-Concentrating Hormone | Principal | 1 | Peptide | Refs | ||||||
A (Rhodopsin) | Bile acid | GPBAR | GPBA | Human | Cholic Acid | None | 4 | Small molecule | 5.0 | 5.0 | Refs | ||||
A (Rhodopsin) | Kisspeptin | KISSR | kisspeptin | Human | Kisspeptin-52 | 5 | Peptide | ||||||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Cck-4 | 4 | Peptide | Refs | |||||||
A (Rhodopsin) | Leukotriene | OXER1 | OXE | Human | 5s-Hpete | None | 4 | Small molecule | 7.0 | 7.0 | Refs | ||||
A (Rhodopsin) | Opioid | OPRK | κ | Rat | Α-Neoendorphin | 3 | Peptide | 8.9 | 9.5 | 10.0 | Refs | ||||
A (Rhodopsin) | P2Y | P2RY4 | P2Y4 | Rat | Utp | None | 1 | Small molecule | 5.6 | 5.6 | Refs | ||||
C (Glutamate) | Metabotropic glutamate | GRM2 | mGlu2 | Human | L-Glutamic Acid | Principal | 1 | Small molecule | 4.7 | 5.1 | 5.4 | 5.4 | 4.9 | 4.9 | Refs |
C (Glutamate) | Calcium-sensing | CASR | CaS | Human | Mg2+ | None | 3 | Small molecule | |||||||
A (Rhodopsin) | Class A orphan | GP183 | GPR183 | Human | 7Β, 25-Dihydroxycholesterol | None | 3 | Small molecule | 8.7 | 8.7 | Refs | ||||
A (Rhodopsin) | Neuropeptide Y | NPY1R | Y1 | Human | Pancreatic Polypeptide | 4 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR7 | CCR7 | Human | Ccl19 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Opioid | OPRD | δ | Human | Dynorphin A-(1-13) | 4 | Peptide | 7.8 | 7.8 | Refs | |||||
B1 (Secretin) | Glucagon receptor family | SCTR | secretin | Rat | Secretin | 2 | Peptide | 8.0 | 8.5 | 9.0 | Refs | ||||
A (Rhodopsin) | Free fatty acid | FFAR1 | FFA1 | Human | Myristic Acid | None | 3 | Small molecule | 4.5 | 4.8 | 5.1 | Refs | |||
A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Rat | Bradykinin | 5 | Peptide | 5.1 | 5.2 | 5.3 | Refs | ||||
A (Rhodopsin) | P2Y | P2Y11 | P2Y11 | Human | Atp | None | 2 | Small molecule | 4.2 | 4.9 | 5.6 | Refs | |||
A (Rhodopsin) | Angiotensin | AGTR1 | AT1 | Human | Angiotensin Iii | 3 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | MRGX1 | MRGPRX1 | Human | Bovine Adrenal Medulla Peptide 8-22 | Principal | 1 | Peptide | 5.3 | 6.6 | 7.8 | 7.7 | 7.7 | Refs | |
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Ltc4 | 9 | Small molecule | ||||||||
A (Rhodopsin) | Histamine | HRH2 | H2 | Human | Histamine | Principal | 1 | Small molecule | |||||||
A (Rhodopsin) | Somatostatin | SSR2 | SST2 | Human | Srif-14 | 1 | Peptide | 9.0 | 9.1 | 9.1 | 8.9 | 9.7 | 10.5 | Refs | |
A (Rhodopsin) | Galanin | GALR1 | GAL1 | Human | Galanin-Like Peptide | 2 | Peptide | Refs | |||||||
B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Secretin | 4 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Mouse | Pgd2 | None | 2 | Small molecule | 7.6 | 8.1 | 8.6 | Refs | |||
F (Frizzled) | Frizzled | FZD6 | FZD6 | Human | Wnt-3a | Peptide | Refs | ||||||||
A (Rhodopsin) | Leukotriene | LT4R2 | BLT2 | Human | 12s-Hpete | 4 | Small molecule | ||||||||
A (Rhodopsin) | Prostanoid | PI2R | IP | Human | Pge1 | None | 2 | Small molecule | 6.5 | 6.7 | 6.8 | Refs | |||
A (Rhodopsin) | Class A orphan | GP139 | GPR139 | Human | L-Phenylalanine | None | 2 | Small molecule | 3.5 | 3.5 | 3.1 | 3.1 | Refs | ||
A (Rhodopsin) | Succinate | SUCR1 | succinate | Human | Succinic Acid | Principal | 1 | Small molecule | 3.1 | 3.9 | 4.7 | Refs | |||
A (Rhodopsin) | Chemokine | CXCR5 | CXCR5 | Human | Cxcl13 | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl5 | 5 | Peptide | ||||||||
A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Mouse | [Des-Arg9]Bradykinin | 2 | Peptide | 5.7 | 9.2 | 9.2 | Refs | ||||
A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Mouse | 3-Iodothyronamine | None | 1 | Small molecule | 7.5 | 7.7 | 7.9 | Refs | |||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl24 | 5 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW2 | NPBW2 | Human | Neuropeptide W-30 | 5 | Peptide | ||||||||
A (Rhodopsin) | Prokineticin | PKR1 | PKR1 | Human | Prokineticin-2 | 4 | Peptide | ||||||||
A (Rhodopsin) | Histamine | HRH1 | H1 | Human | Histamine | Principal | 1 | Small molecule | 4.7 | 5.3 | 5.9 | Refs | |||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl11 | 5 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR6 | CCR6 | Human | Beta-Defensin 4a | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Bradykinin | BKRB2 | B2 | Human | Lys-[Hyp3]-Bradykinin | 3 | Peptide | ||||||||
B1 (Secretin) | Calcitonin | CALCR | CT | Human | Amylin | 7 | Peptide | ||||||||
A (Rhodopsin) | Endothelin | EDNRB | ETB | Human | Endothelin-3 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl14 | 6 | Peptide | 7.4 | 7.4 | Refs | |||||
A (Rhodopsin) | Galanin | GALR2 | GAL2 | Mouse | Galanin | 2 | Peptide | 8.3 | 8.3 | 8.3 | 8.4 | 8.4 | Refs | ||
A (Rhodopsin) | Galanin | GALR2 | GAL2 | Human | Galanin-Like Peptide | 4 | Peptide | Refs | |||||||
A (Rhodopsin) | Melanocortin | MC4R | MC4 | Human | Β-Msh | 3 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GP139 | GPR139 | Human | L-Tryptophan | None | 1 | Small molecule | 3.7 | 3.7 | 3.1 | 3.1 | Refs | ||
A (Rhodopsin) | Neuropeptide Y | Q9ERC0 | Y2 | Rat | Neuropeptide Y | 4 | Peptide | 9.3 | 9.4 | 9.5 | Refs | ||||
A (Rhodopsin) | Adren | ADA1B | α1B-adren | Human | (-)-Noradrenaline | None | 2 | Small molecule | 6.2 | 6.2 | Refs | ||||
C (Glutamate) | Class C Orphan | GPC6A | GPRC6 | Human | L-Glutamine | None | 5 | Small molecule | 3.2 | 3.2 | Refs | ||||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR5 | S1P5 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.4 | 8.2 | 8.9 | Refs | |||
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Cxcl10 | 2 | Peptide | 7.8 | 8.8 | 9.8 | Refs | ||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2A | 5-HT2A | Human | Tryptamine | None | 1 | Small molecule | 5.5 | 6.6 | 7.6 | Refs | |||
A (Rhodopsin) | Adren | ADRB3 | β3-adren | Mouse | (&Plusmn;)-Adrenaline | None | 1 | Small molecule | 3.9 | 5.3 | 5.3 | Refs | |||
A (Rhodopsin) | Adren | ADRB3 | β3-adren | Rat | (+)-Adrenaline | None | 1 | Small molecule | |||||||
A (Rhodopsin) | Bombesin | NMBR | BB1 | Human | Grp-(18-27) | 2 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide S | NPSR1 | NPS | Human | Neuropeptide S | Principal | 1 | Peptide | |||||||
B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Pacap-38 | 2 | Peptide | 7.5 | 8.9 | 10.3 | 6.9 | 8.2 | 9.0 | Refs | |
A (Rhodopsin) | Class A orphan | GPR39 | GPR39 | Human | Obestatin | Peptide | |||||||||
A (Rhodopsin) | Melanocortin | MC3R | MC3 | Human | Agouti-Related Protein | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Formylpeptide | FPR1 | FPR1 | Human | Annexin I | 2 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GPR35 | GPR35 | Human | 2-Oleoyl-Lpa | None | 1 | Small molecule | 7.3 | 7.4 | 7.5 | Refs | |||
A (Rhodopsin) | Relaxin family peptide | RXFP1 | RXFP1 | Human | Relaxin-1 | 2 | Peptide | 8.8 | 8.8 | Refs | |||||
B1 (Secretin) | Corticotropin-releasing factor | CRFR1 | CRF1 | Human | Urocortin 1 | 4 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide W-30 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Hydroxycarboxylic acid | HCAR2 | HCA2 | Human | Butyric Acid | None | 2 | Small molecule | 2.8 | 2.8 | |||||
A (Rhodopsin) | Histamine | HRH4 | H4 | Human | Ccl16 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | GPR18, GPR55 and GPR119 | GP119 | GPR119 | Human | N-Oleoylethanolamide | None | 1 | Small molecule | 5.4 | 5.9 | 6.3 | Refs | |||
A (Rhodopsin) | Class A orphan | LGR4 | LGR4 | Human | R-Spondin-3 | 2 | Peptide | 10.7 | 10.7 | Refs | |||||
A (Rhodopsin) | Chemokine | XCR1 | XCR1 | Human | Xcl1 | 2 | Peptide | ||||||||
A (Rhodopsin) | Opioid | OPRM | μ | Rat | [Met]Enkephalin | 1 | Peptide | 9.2 | 9.2 | Refs | |||||
A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Human | Large Neuromedin N | 3 | Peptide | Refs | |||||||
B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Human | Urocortin 2 | 2 | Peptide | ||||||||
B1 (Secretin) | Calcitonin | CALCR | CT | Human | Calcitonin | 1 | Peptide | 9.0 | 10.1 | 11.2 | Refs | ||||
A (Rhodopsin) | Bradykinin | BKRB2 | B2 | Human | Bradykinin | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Dopamine | DRD1 | D1 | Human | Dopamine | None | 2 | Small molecule | 4.3 | 5.0 | 5.6 | Refs | |||
A (Rhodopsin) | Class A orphan | G37L1 | GPR37L1 | Human | Prosaptide | Principal | 1 | Peptide | 8.3 | 8.3 | Refs | ||||
A (Rhodopsin) | Prokineticin | PKR1 | PKR1 | Human | Prokineticin-2Β | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR2 | LPA2 | Human | Lpa | None | 1 | Small molecule | 6.7 | 7.5 | 8.2 | Refs | |||
A (Rhodopsin) | Chemokine | ACKR1 | ACKR1 | Human | Cxcl11 | Peptide | |||||||||
A (Rhodopsin) | Apelin | APJ | apelin | Human | Apelin Receptor Early Endogenous Ligand | 2 | Peptide | ||||||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Resolvin D1 | None | 2 | Small molecule | 11.9 | 11.9 | Refs | ||||
A (Rhodopsin) | Class A orphan | MRGRD | MRGPRD | Human | Β-Alanine | Principal | 1 | Small molecule | 4.8 | 4.8 | Refs | ||||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl2 | 3 | Peptide | ||||||||
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Ghrh | 4 | Peptide | 6.2 | 6.2 | Refs | |||||
A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Pgf2Α | None | 3 | Small molecule | 6.1 | 6.1 | 9.1 | 9.3 | 9.5 | Refs | |
A (Rhodopsin) | Galanin | GALR2 | GAL2 | Human | Galanin | 1 | Peptide | 7.9 | 8.5 | 9.1 | 8.6 | 8.9 | 9.1 | Refs | |
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl2 | 8 | Peptide | ||||||||
B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Ghrh | 4 | Peptide | ||||||||
A (Rhodopsin) | Adren | ADA1D | α1D-adren | Rat | (-)-Noradrenaline | None | 2 | Small molecule | 6.3 | 6.3 | Refs | ||||
A (Rhodopsin) | Leukotriene | OXER1 | OXE | Human | 5s-Hete | None | 5 | Small molecule | 6.5 | 6.9 | 7.2 | Refs | |||
A (Rhodopsin) | Relaxin family peptide | RL3R1 | RXFP3 | Human | Relaxin-3 (B Chain) | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Formylpeptide | FPR1 | FPR1 | Human | Fmet-Leu-Phe | None | 1 | Peptide | 10.1 | 10.2 | 10.2 | Refs | |||
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Cxcl10 | 9 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Rat | Pgd2 | None | 2 | Small molecule | 7.6 | 8.1 | 8.6 | Refs | |||
A (Rhodopsin) | Chemokine | CCR4 | CCR4 | Human | Ccl22 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Prolactin-releasing peptide | PRLHR | PrRP | Human | Pthrp | 4 | Peptide | ||||||||
B1 (Secretin) | Glucagon receptor family | SCTR | secretin | Human | Secretin | 2 | Peptide | ||||||||
A (Rhodopsin) | Leukotriene | LT4R1 | BLT1 | Human | 20-Hydroxy-Ltb4 | None | 2 | Small molecule | 8.1 | 8.1 | Refs | ||||
A (Rhodopsin) | Prostanoid | PF2R | FP | Mouse | Pge2 | None | 3 | Small molecule | 6.4 | 6.7 | 6.9 | Refs | |||
A (Rhodopsin) | Neuropeptide Y | NPY2R | Y2 | Human | Peptide Yy | 2 | Peptide | 9.5 | 9.7 | 9.8 | Refs | ||||
A (Rhodopsin) | Bombesin | NMBR | BB1 | Human | Gastrin-Releasing Peptide | 2 | Peptide | ||||||||
C (Glutamate) | Calcium-sensing | CASR | CaS | Rat | Ca2+ | None | 2 | Small molecule | Refs | ||||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl3 | 1 | Peptide | 7.8 | 9.0 | 10.2 | Refs | ||||
A (Rhodopsin) | Relaxin family peptide | RXFP2 | RXFP2 | Human | Relaxin | 1 | Peptide | 9.1 | 9.1 | 8.3 | 8.4 | 8.5 | Refs | ||
A (Rhodopsin) | Adren | ADRB2 | β2-adren | Human | Zn2+ | None | 4 | Small molecule | 3.3 | 4.3 | 5.3 | Refs | |||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR4 | S1P4 | Human | Sphingosylphosphorylcholine | 2 | Small molecule | ||||||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT6R | 5-HT6 | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.8 | 7.2 | 7.5 | Refs | |||
A (Rhodopsin) | Dopamine | DRD5 | D5 | Human | Noradrenaline | None | 3 | Small molecule | 4.9 | 4.9 | Refs | ||||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR2 | S1P2 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 8.1 | 8.7 | 8.7 | Refs | |||
A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Mouse | Ltc4 | None | 2 | Small molecule | 7.8 | 9.1 | 9.1 | Refs | |||
A (Rhodopsin) | Bradykinin | BKRB2 | B2 | Human | Kallidin | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | ACKR1 | ACKR1 | Human | Cxcl5 | Peptide | |||||||||
A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Human | Pgf2Α | None | 4 | Small molecule | 6.4 | 6.4 | Refs | ||||
A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Human | Pgd2 | None | 4 | Small molecule | 5.0 | 5.0 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl16 | 8 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GPR63 | GPR63 | Human | Dioleoylphosphatidic Acid | None | 1 | Small molecule | 6.3 | 6.3 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl26 | 5 | Peptide | Refs | |||||||
A (Rhodopsin) | Prokineticin | PKR2 | PKR2 | Human | Prokineticin-1 | 2 | Peptide | Refs | |||||||
C (Glutamate) | Metabotropic glutamate | GRM3 | mGlu3 | Rat | L-Glutamic Acid | None | 1 | Small molecule | 5.3 | 5.4 | 5.4 | 6.4 | 6.4 | Refs | |
A (Rhodopsin) | Opioid | OPRM | μ | Human | [Met]Enkephalin | 1 | Peptide | 9.2 | 9.2 | Refs | |||||
A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Cck-39 | 2 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Neuropeptide Ff | 2 | Peptide | 8.5 | 9.2 | 9.9 | Refs | ||||
A (Rhodopsin) | P2Y | P2RY1 | P2Y1 | Human | Atp | None | 1 | Small molecule | 4.8 | 4.8 | Refs | ||||
B1 (Secretin) | Parathyroid hormone | PTH1R | PTH1 | Human | Pth | 3 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl1 | 3 | Peptide | ||||||||
A (Rhodopsin) | Proteinase-activated | PAR4 | PAR4 | Human | Thrombin | Peptide | |||||||||
A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM2 | M2 | Rat | Acetylcholine | Principal | 1 | Small molecule | 4.3 | 5.4 | 6.5 | Refs | |||
A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Rat | Neuromedin N | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Dopamine | DRD2 | D2 | Human | Dopamine | Principal | 1 | Small molecule | 5.3 | 5.9 | 6.4 | Refs | |||
A (Rhodopsin) | Opioid | OPRK | κ | Human | [Met]Enkephalin | 8 | Peptide | 6.0 | 6.0 | Refs | |||||
A (Rhodopsin) | Chemokine | ACKR1 | ACKR1 | Human | Ccl2 | Peptide | |||||||||
A (Rhodopsin) | P2Y | P2Y13 | P2Y13 | Human | Atp | None | 2 | Small molecule | Refs | ||||||
A (Rhodopsin) | Tachykinin | NK3R | NK3 | Human | Neurokinin A | 2 | Peptide | 7.4 | 7.4 | 5.5 | 5.9 | 6.3 | Refs | ||
A (Rhodopsin) | Free fatty acid | FFAR2 | FFA2 | Human | Trans-2-Methylcrotonic Acid | None | 3 | Small molecule | 3.8 | 3.8 | Refs | ||||
A (Rhodopsin) | Class A orphan | LGR5 | LGR5 | Human | R-Spondin-1 | 2 | Peptide | 11.1 | 11.1 | Refs | |||||
A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Human | Peptide Yy | 3 | Peptide | 8.8 | 8.8 | Refs | |||||
A (Rhodopsin) | P2Y | P2Y11 | P2Y11 | Human | Utp | None | 1 | Small molecule | 5.2 | 5.2 | Refs | ||||
C (Glutamate) | Metabotropic glutamate | GRM1 | mGlu1 | Rat | L-Glutamic Acid | Principal | 1 | Small molecule | 4.8 | 4.9 | 5.0 | 6.4 | 6.5 | 6.5 | Refs |
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Ccl11 | 4 | Peptide | 7.2 | 7.2 | Refs | |||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW2 | NPBW2 | Human | Neuropeptide B-23 | 5 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl2 | 6 | Peptide | 7.5 | 7.5 | Refs | |||||
A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Α-Msh | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Tachykinin | NK3R | NK3 | Mouse | Neurokinin A | 2 | Peptide | 7.4 | 7.4 | 5.5 | 5.9 | 6.3 | Refs | ||
A (Rhodopsin) | Bile acid | GPBAR | GPBA | Human | Lithocholic Acid | None | 1 | Small molecule | 7.5 | 7.5 | Refs | ||||
A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Rat | T-Kinin | 4 | Peptide | 5.0 | 5.2 | 5.2 | Refs | ||||
A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Human | Udp-Galactose | None | 5 | Small molecule | 6.0 | 7.2 | 7.2 | Refs | |||
A (Rhodopsin) | Leukotriene | LT4R2 | BLT2 | Human | Ltb4 | None | 3 | Small molecule | 6.8 | 6.8 | Refs | ||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1B | 5-HT1B | Mouse | 5-Hydroxytryptamine | None | 1 | Small molecule | 7.4 | 8.1 | 8.1 | Refs | |||
A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl4 | Peptide | |||||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide B-29 | 5 | Peptide | ||||||||
A (Rhodopsin) | Dopamine | DRD5 | D5 | Human | Dopamine | None | 1 | Small molecule | 6.6 | 6.6 | Refs | ||||
A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Human | Pgi2 | 5 | Small molecule | ||||||||
A (Rhodopsin) | Dopamine | DRD1 | D1 | Human | (-)-Noradrenaline | None | 3 | Small molecule | |||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl7 | 3 | Peptide | 8.6 | 8.9 | 9.2 | Refs | ||||
A (Rhodopsin) | Leukotriene | CLTR2 | CysLT2 | Human | Ltc4 | None | 1 | Small molecule | 7.0 | 7.6 | 8.6 | Refs | |||
A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Mouse | Pgf2Α | None | 4 | Small molecule | 6.4 | 6.4 | Refs | ||||
A (Rhodopsin) | Opioid | OPRK | κ | Human | Big Dynorphin | 9 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl4 | 7 | Peptide | ||||||||
A (Rhodopsin) | Opioid | OPRD | δ | Mouse | [Leu]Enkephalin | 1 | Peptide | 8.7 | 8.7 | Refs | |||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl8 | 7 | Peptide | ||||||||
A (Rhodopsin) | Neuromedin U | NMUR1 | NMU1 | Human | Neuromedin U-23 | 3 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR10 | CCR10 | Human | Ccl28 | Peptide | |||||||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Cck-33 | 5 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Human | Lte4 | None | 1 | Small molecule | |||||||
A (Rhodopsin) | Class A orphan | TAAR2 | TAAR2 | Human | Β-Phenylethylamine | Small molecule | |||||||||
A (Rhodopsin) | Chemokine | CCR8 | CCR8 | Human | Ccl1 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Rat | Udp | None | 2 | Small molecule | 7.1 | 7.1 | Refs | ||||
A (Rhodopsin) | Neuropeptide S | NPSR1 | NPS | Human | Neuropeptide S | Principal | 1 | Peptide | 7.3 | 7.7 | 8.0 | Refs | |||
A (Rhodopsin) | Prokineticin | PKR2 | PKR2 | Human | Prokineticin-2 | 4 | Peptide | ||||||||
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Mouse | Udp-Glucuronic Acid | None | 3 | Small molecule | 7.0 | 7.0 | Refs | ||||
A (Rhodopsin) | Class A orphan | TAAR3 | TAAR3 | Human | Isoamylamine | Principal | 1 | Small molecule | |||||||
A (Rhodopsin) | Prolactin-releasing peptide | PRLHR | PrRP | Human | Neuropeptide Y | 3 | Peptide | 5.4 | 5.4 | Refs | |||||
B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Ghrh | 4 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl8 | 7 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | LGR4 | LGR4 | Human | R-Spondin-4 | 3 | Peptide | 10.1 | 10.1 | Refs | |||||
A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Rat | Srif-14 | 3 | Peptide | 8.4 | 9.2 | 9.9 | Refs | ||||
A (Rhodopsin) | Thyrotropin-releasing hormone | TRHR | TRH1 | Rat | Trh | Principal | 1 | Peptide | 7.4 | 7.4 | Refs | ||||
A (Rhodopsin) | Bombesin | GRPR | BB2 | Human | Gastrin Releasing Peptide(14-27) (Human) | None | 3 | Peptide | Refs | ||||||
A (Rhodopsin) | Bombesin | GRPR | BB2 | Human | Grp-(18-27) | 3 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide Y | NPY2R | Y2 | Human | Peptide Yy | 1 | Peptide | 10.0 | 10.0 | Refs | |||||
A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Human | Cst-17 | 2 | Peptide | 8.7 | 9.3 | 9.9 | Refs | ||||
A (Rhodopsin) | Angiotensin | AGTR1 | AT1 | Human | Angiotensin Iv | 2 | Peptide | 5.9 | 5.9 | Refs | |||||
A (Rhodopsin) | Class A orphan | LGR4 | LGR4 | Human | R-Spondin-2 | 1 | Peptide | 12.5 | 12.5 | Refs | |||||
A (Rhodopsin) | Tachykinin | NK3R | NK3 | Mouse | Neurokinin B | 1 | Peptide | 8.4 | 8.4 | 7.7 | 8.5 | 9.2 | Refs | ||
A (Rhodopsin) | Apelin | APJ | apelin | Human | Apelin-36 | 2 | Peptide | ||||||||
A (Rhodopsin) | Dopamine | DRD5 | D5 | Human | (-)-Noradrenaline | None | 3 | Small molecule | |||||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR2 | LPA2 | Mouse | Lpa | None | 1 | Small molecule | 6.7 | 7.5 | 8.2 | Refs | |||
A (Rhodopsin) | P2Y | P2Y12 | P2Y12 | Human | Adp | None | 1 | Small molecule | 5.9 | 5.9 | Refs | ||||
A (Rhodopsin) | Chemokine | CXCR1 | CXCR1 | Human | Cxcl6 | 2 | Peptide | 7.0 | 7.0 | Refs | |||||
A (Rhodopsin) | Tachykinin | NK3R | NK3 | Mouse | Hemokinin 1 | 3 | Peptide | 9.2 | 9.3 | 9.3 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl15 | 7 | Peptide | Refs | |||||||
A (Rhodopsin) | Free fatty acid | FFAR4 | FFA4 | Rat | Α-Linolenic Acid | None | 3 | Small molecule | 5.1 | 5.1 | Refs | ||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW2 | NPBW2 | Human | Neuropeptide W-30 | 5 | Peptide | ||||||||
B1 (Secretin) | Glucagon receptor family | GHRHR | GHRH | Human | Ghrh | Principal | 1 | Peptide | |||||||
C (Glutamate) | Class C Orphan | GPC6A | GPRC6 | Human | L-Arginine | None | 1 | Small molecule | 4.4 | 4.4 | Refs | ||||
A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Mouse | Neuromedin N | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | CCR9 | CCR9 | Human | Ccl25 | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Neuropeptide Y | NPY2R | Y2 | Human | Neuropeptide Y | 4 | Peptide | 9.3 | 9.4 | 9.5 | Refs | ||||
A (Rhodopsin) | Peptide P518 | QRFPR | QRFP | Human | Qrfp43 (43rfa) | 3 | Peptide | 6.9 | 7.8 | 8.6 | Refs | ||||
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Human | Udp-Galactose | None | 1 | Small molecule | 7.6 | 7.6 | Refs | ||||
A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Pgd2 | None | 2 | Small molecule | 8.8 | 8.8 | 8.7 | 8.9 | 9.0 | Refs | |
A (Rhodopsin) | Galanin | GALR3 | GAL3 | Rat | Galanin | 2 | Peptide | 8.1 | 8.5 | 8.8 | Refs | ||||
B1 (Secretin) | Calcitonin | CALCR | CT | Human | Amylin | 3 | Peptide | 8.0 | 8.6 | 9.2 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl5 | 8 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Mouse | Pge1 | None | 1 | Small molecule | 9.4 | 9.4 | 9.0 | 9.0 | Refs | ||
A (Rhodopsin) | Tachykinin | NK2R | NK2 | Human | Neurokinin B | 3 | Peptide | 5.0 | 6.4 | 7.7 | Refs | ||||
A (Rhodopsin) | Melanocortin | MC4R | MC4 | Human | Β-Msh | 3 | Peptide | ||||||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Fmet-Leu-Phe | None | 9 | Peptide | |||||||
A (Rhodopsin) | Leukotriene | CLTR2 | CysLT2 | Human | Lte4 | None | 3 | Small molecule | 5.6 | 6.3 | 7.1 | 6.5 | 6.5 | Refs | |
B1 (Secretin) | Calcitonin | CALCR | CT | Human | Β-Cgrp | 7 | Peptide | ||||||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT5B | 5HT5B | Mouse | 5-Hydroxytryptamine | Principal | 1 | Small molecule | |||||||
A (Rhodopsin) | Relaxin family peptide | RL3R2 | RXFP4 | Human | Relaxin-3 | 1 | Peptide | 8.7 | 9.2 | 9.7 | 8.8 | 8.9 | 9.0 | Refs | |
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR3 | LPA3 | Human | Lpa | None | 1 | Small molecule | 6.6 | 6.6 | Refs | ||||
A (Rhodopsin) | Adren | ADRB3 | β3-adren | Mouse | (-)-Noradrenaline | None | 2 | Small molecule | 4.7 | 4.2 | 4.2 | Refs | |||
B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Human | Pth | 5 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | ACKR3 | ACKR3 | Human | Cxcl12Α | 1 | Peptide | 7.5 | 7.7 | 7.9 | Refs | ||||
A (Rhodopsin) | Class A orphan | GP183 | GPR183 | Human | 7Β, 27-Dihydroxycholesterol | None | 4 | Small molecule | 7.3 | 7.3 | Refs | ||||
A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Human | Pancreatic Polypeptide | 7 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Cxcl10 | 5 | Peptide | ||||||||
A (Rhodopsin) | Cannabinoid | CNR2 | CB2 | Human | 2-Arachidonoylglycerol | None | 1 | Small molecule | 5.8 | 6.3 | 6.8 | Refs | |||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Desulfated Gastrin-17 | 5 | Peptide | ||||||||
A (Rhodopsin) | Adren | ADA2A | α2A-adren | Human | (-)-Noradrenaline | None | 2 | Small molecule | 5.6 | 6.5 | 7.4 | Refs | |||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl7 | 7 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Cxcl9 | 3 | Peptide | 7.3 | 7.8 | 8.3 | Refs | ||||
A (Rhodopsin) | Class A orphan | GP183 | GPR183 | Human | 27-Hydroxycholesterol | None | 8 | Small molecule | 5.5 | 5.5 | Refs | ||||
A (Rhodopsin) | Melanocortin | MC4R | MC4 | Human | Α-Msh | 1 | Peptide | 7.4 | 7.7 | 8.0 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl8 | 8 | Peptide | ||||||||
A (Rhodopsin) | Melanocortin | ACTHR | MC2 | Mouse | Acth | Principal | 1 | Peptide | Refs | ||||||
A (Rhodopsin) | Chemokine | CCR7 | CCR7 | Mouse | Ccl21b | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Human | Kallidin | 3 | Peptide | 7.0 | 8.0 | 8.9 | Refs | ||||
A (Rhodopsin) | Class A orphan | LGR6 | LGR6 | Human | R-Spondin-3 | Peptide | Refs | ||||||||
A (Rhodopsin) | Opioid | OPRD | δ | Mouse | [Met]Enkephalin | 7 | Peptide | Refs | |||||||
A (Rhodopsin) | Bradykinin | BKRB2 | B2 | Mouse | Bradykinin | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Bombesin | GRPR | BB2 | Rat | Neuromedin B | 2 | Peptide | 6.4 | 6.6 | 6.6 | Refs | ||||
A (Rhodopsin) | Neuropeptide Y | NPY1R | Y1 | Human | Neuropeptide Y | 1 | Peptide | 10.5 | 10.5 | Refs | |||||
A (Rhodopsin) | Bombesin | GRPR | BB2 | Human | Neuromedin C | None | 3 | Peptide | Refs | ||||||
A (Rhodopsin) | Melanocortin | MSHR | MC1 | Human | Α-Msh | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Rat | Pgd2 | None | 4 | Small molecule | 5.0 | 5.0 | Refs | ||||
A (Rhodopsin) | Cannabinoid | CNR2 | CB2 | Human | Anandamide | None | 2 | Small molecule | 5.7 | 6.1 | 6.4 | Refs | |||
A (Rhodopsin) | Adenosine | AA3R | A3 | Rat | Adenosine | Principal | 1 | Small molecule | 6.5 | 6.5 | Refs | ||||
C (Glutamate) | Calcium-sensing | CASR | CaS | Rat | Mg2+ | None | 3 | Small molecule | Refs | ||||||
A (Rhodopsin) | Tachykinin | NK2R | NK2 | Human | Neurokinin A | 1 | Peptide | 8.0 | 8.6 | 9.1 | Refs | ||||
A (Rhodopsin) | Opioid | OPRD | δ | Human | Β-Endorphin | 3 | Peptide | 8.3 | 8.3 | Refs | |||||
A (Rhodopsin) | Class A orphan | GPR75 | GPR75 | Human | Ccl5 | Principal | 1 | Peptide | 9.6 | 9.6 | Refs | ||||
A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Pgd2 | None | 4 | Small molecule | 5.2 | 5.2 | Refs | ||||
A (Rhodopsin) | Prolactin-releasing peptide | PRLHR | PrRP | Human | Prrp-20 | 4 | Peptide | ||||||||
A (Rhodopsin) | Somatostatin | SSR1 | SST1 | Rat | Srif-14 | 2 | Peptide | 8.6 | 9.1 | 9.5 | Refs | ||||
A (Rhodopsin) | Melanocortin | MSHR | MC1 | Mouse | Agouti | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Adren | ADRB3 | β3-adren | Human | (-)-Noradrenaline | None | 2 | Small molecule | 4.7 | 4.2 | 4.2 | Refs | |||
A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Gastrin-17 | 2 | Peptide | ||||||||
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Secretin | 4 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide B-29 | 5 | Peptide | ||||||||
F (Frizzled) | Frizzled | FZD6 | FZD6 | Human | Wnt-4 | Peptide | Refs | ||||||||
A (Rhodopsin) | Apelin | APJ | apelin | Human | Apelin Receptor Early Endogenous Ligand | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Mouse | Pgj2 | None | 1 | Small molecule | 8.2 | 8.2 | Refs | ||||
A (Rhodopsin) | Prostanoid | PF2R | FP | Mouse | Pgd2 | None | 2 | Small molecule | 7.7 | 7.7 | Refs | ||||
A (Rhodopsin) | Prokineticin | PKR1 | PKR1 | Human | Prokineticin-1 | 4 | Peptide | ||||||||
B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Rat | Pthrp-(1-34) (Human) | None | 3 | Peptide | Refs | ||||||
B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Phv | 4 | Peptide | ||||||||
B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Human | Corticotrophin-Releasing Hormone | 1 | Peptide | 7.8 | 7.8 | Refs | |||||
A (Rhodopsin) | Opioid | OPRX | NOP | Human | Nociceptin/Orphanin Fq | Principal | 1 | Peptide | 8.4 | 9.1 | 9.8 | 9.7 | 10.1 | 10.4 | Refs |
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Rat | Pgd2 | None | 3 | Small molecule | 7.9 | 7.9 | 5.9 | 7.4 | 8.9 | Refs | |
A (Rhodopsin) | Adenosine | AA2BR | A2B | Human | Adenosine | Principal | 1 | Small molecule | 5.3 | 5.3 | Refs | ||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Desulfated Cholecystokinin-8 | None | 3 | Peptide | Refs | ||||||
A (Rhodopsin) | Class A orphan | GP183 | GPR183 | Human | 7Α-Hydroxycholesterol | None | 5 | Small molecule | 7.1 | 7.1 | Refs | ||||
A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Human | [Des-Arg10]Kallidin | 1 | Peptide | 9.6 | 9.8 | 10.0 | Refs | ||||
C (Glutamate) | Metabotropic glutamate | GRM6 | mGlu6 | Rat | L-Glutamic Acid | None | 2 | Small molecule | 4.8 | 5.0 | 5.2 | Refs | |||
A (Rhodopsin) | Class A orphan | GPR39 | GPR39 | Human | Obestatin | Peptide | |||||||||
A (Rhodopsin) | P2Y | P2Y13 | P2Y13 | Human | Adp | None | 1 | Small molecule | Refs | ||||||
A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Human | Lys-[Hyp3]-Bradykinin | 6 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | ACKR4 | ACKR4 | Human | Ccl21 | 2 | Peptide | 7.9 | 8.2 | 8.5 | 6.9 | 6.9 | Refs | ||
A (Rhodopsin) | Proteinase-activated | PAR3 | PAR3 | Human | Thrombin | Principal | 1 | Peptide | |||||||
B1 (Secretin) | Calcitonin | CALCR | CT | Human | Β-Cgrp | 5 | Peptide | 7.2 | 7.2 | Refs | |||||
A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Human | Pgi2 | None | 4 | Small molecule | 5.1 | 5.1 | Refs | ||||
A (Rhodopsin) | Opioid | OPRK | κ | Mouse | Α-Neoendorphin | 3 | Peptide | 8.9 | 9.5 | 10.0 | Refs | ||||
A (Rhodopsin) | Melanocortin | MSHR | MC1 | Human | Β-Msh | 2 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl8 | 1 | Peptide | 8.8 | 9.2 | 9.5 | Refs | ||||
A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Rat | Neuromedin N | 2 | Peptide | 8.7 | 8.7 | Refs | |||||
A (Rhodopsin) | Class A orphan | LGR6 | LGR6 | Human | R-Spondin-2 | Peptide | Refs | ||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl11 | 1 | Peptide | 9.7 | 9.9 | 10.0 | Refs | ||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT2C | 5-HT2C | Human | 5-Hydroxytryptamine | Principal | 1 | Small molecule | 6.8 | 7.7 | 8.6 | Refs | |||
A (Rhodopsin) | Tachykinin | NK1R | NK1 | Human | Hemokinin 1 | 4 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR10 | CCR10 | Human | Ccl27 | Peptide | |||||||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1B | 5-HT1B | Human | Tryptamine | None | 2 | Small molecule | 6.3 | 6.3 | Refs | ||||
A (Rhodopsin) | Bile acid | GPBAR | GPBA | Human | Chenodeoxycholic Acid | None | 3 | Small molecule | 5.4 | 5.4 | Refs | ||||
B1 (Secretin) | Glucagon receptor family | GHRHR | GHRH | Human | Ghrh | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Class A orphan | GP174 | GPR174 | Human | Lysophosphatidylserine | Principal | 1 | Small molecule | 7.1 | 7.1 | Refs | ||||
A (Rhodopsin) | Prostanoid | PI2R | IP | Human | Thromboxane A2 | 3 | Small molecule | ||||||||
A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl2 | Peptide | |||||||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Cck-8 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Prostanoid | PE2R4 | EP4 | Rat | Pge1 | None | 1 | Small molecule | 9.5 | 9.5 | 8.7 | 8.7 | Refs | ||
C (Glutamate) | Metabotropic glutamate | GRM1 | mGlu1 | Human | L-Glutamic Acid | Principal | 1 | Small molecule | 4.8 | 4.9 | 5.0 | 6.4 | 6.5 | 6.5 | Refs |
A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Pge1 | None | 2 | Small molecule | 7.0 | 7.0 | Refs | ||||
A (Rhodopsin) | Bradykinin | BKRB2 | B2 | Human | [Des-Arg10]Kallidin | 3 | Peptide | ||||||||
A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM1 | M1 | Human | Acetylcholine | Principal | 1 | Small molecule | 4.3 | 4.6 | 4.9 | Refs | |||
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Cxcl9 | 9 | Peptide | ||||||||
A (Rhodopsin) | Opioid | OPRK | κ | Rat | [Met]Enkephalin | 8 | Peptide | 6.0 | 6.0 | Refs | |||||
A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Mouse | Neurotensin | 1 | Peptide | 8.8 | 8.8 | Refs | |||||
B1 (Secretin) | Corticotropin-releasing factor | CRFR1 | CRF1 | Human | Urocortin 2 | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Human | [Des-Arg9]Bradykinin | 2 | Peptide | 5.7 | 9.2 | 9.2 | Refs | ||||
A (Rhodopsin) | Class A orphan | GPR12 | GPR12 | Human | Sphingosine 1-Phosphate | Principal | 1 | Small molecule | 5.5 | 6.3 | 7.0 | Refs | |||
A (Rhodopsin) | Opioid | OPRD | δ | Mouse | Α-Neoendorphin | 7 | Peptide | Refs | |||||||
A (Rhodopsin) | Melanocortin | MC5R | MC5 | Mouse | Agouti | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | CCR4 | CCR4 | Human | Ccl17 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Class A orphan | GP132 | GPR132 | Human | 9-Hydroxyoctadecadienoic Acid | Principal | 1 | Small molecule | 5.7 | 5.7 | Refs | ||||
A (Rhodopsin) | Leukotriene | LT4R2 | BLT2 | Human | 12r-Hete | 4 | Small molecule | ||||||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | 15-Deoxy-Lxa4 | 9 | Small molecule | ||||||||
A (Rhodopsin) | Formylpeptide | FPR1 | FPR1 | Human | Annexin I | 2 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PI2R | IP | Mouse | Pge1 | None | 2 | Small molecule | 6.5 | 6.7 | 6.8 | Refs | |||
A (Rhodopsin) | Neuropeptide Y | NPY1R | Y1 | Human | Peptide Yy | 2 | Peptide | 10.2 | 10.2 | Refs | |||||
A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Pgi2 | None | 5 | Small molecule | 4.8 | 4.8 | Refs | ||||
A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Human | Cortistatin-14 | 4 | Peptide | 8.7 | 9.1 | 9.4 | Refs | ||||
A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Human | Dopamine | 4 | Small molecule | ||||||||
A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Cck-33 | 2 | Peptide | ||||||||
B1 (Secretin) | Parathyroid hormone | PTH1R | PTH1 | Human | Pth | 3 | Peptide | ||||||||
A (Rhodopsin) | Urotensin | UR2R | UT | Human | Urotensin-Ii | 2 | Peptide | 8.6 | 8.6 | Refs | |||||
A (Rhodopsin) | Chemokine | ACKR3 | ACKR3 | Human | Cxcl11 | 3 | Peptide | ||||||||
A (Rhodopsin) | Formylpeptide | FPR3 | FPR3 | Human | Annexin I-(2-26) | 3 | Peptide | 5.0 | 6.0 | 7.0 | Refs | ||||
A (Rhodopsin) | Galanin | GALR2 | GAL2 | Human | Galanin-Like Peptide | 4 | Peptide | ||||||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Cck-58 | 5 | Peptide | ||||||||
C (Glutamate) | Calcium-sensing | CASR | CaS | Human | Spermine | None | 1 | Small molecule | Refs | ||||||
A (Rhodopsin) | Opioid | OPRD | δ | Human | [Leu]Enkephalin | 1 | Peptide | 8.7 | 8.7 | Refs | |||||
A (Rhodopsin) | Adenosine | AA1R | A1 | Rat | Adenosine | Principal | 1 | Small molecule | 7.0 | 7.0 | Refs | ||||
A (Rhodopsin) | Formylpeptide | FPR1 | FPR1 | Human | Cathepsin G | 2 | Peptide | ||||||||
B1 (Secretin) | Glucagon receptor family | GHRHR | GHRH | Human | Ghrh | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Human | Udp | None | 4 | Small molecule | 6.0 | 7.4 | 8.8 | Refs | |||
A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Human | [Hyp3]Bradykinin | 6 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | Human | Rfrp-1 | 3 | Peptide | ||||||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1E | 5-HT1E | Human | Tryptamine | None | 2 | Small molecule | 5.6 | 6.1 | 6.5 | Refs | |||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl2 | 3 | Peptide | ||||||||
A (Rhodopsin) | Opioid | OPRX | NOP | Mouse | Nociceptin/Orphanin Fq | Principal | 1 | Peptide | 8.4 | 9.1 | 9.8 | 9.7 | 10.1 | 10.4 | Refs |
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Des-Br-Neuropeptide B-23 | 4 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl24 | 7 | Peptide | Refs | |||||||
C (Glutamate) | Class C Orphan | GPC6A | GPRC6 | Human | Glycine | None | 4 | Small molecule | 3.6 | 3.6 | Refs | ||||
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Cxcl11 | 9 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GPR63 | GPR63 | Human | Sphingosine 1-Phosphate | None | 3 | Small molecule | 6.1 | 6.2 | 6.2 | Refs | |||
B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Mouse | Urocortin 3 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | CXCR4 | CXCR4 | Human | Cxcl12 | 3 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR8 | CCR8 | Mouse | Ccl8 | 2 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Human | Pge1 | None | 1 | Small molecule | 9.4 | 9.4 | 9.0 | 9.0 | Refs | ||
A (Rhodopsin) | Chemokine | CXCR4 | CXCR4 | Human | Cxcl12Ε | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | P2Y | P2Y11 | P2Y11 | Human | Adp | None | 3 | Small molecule | Refs | ||||||
A (Rhodopsin) | Glycoprotein hormone | FSHR | FSH | Human | Fsh | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Human | Xenin | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | ACKR4 | ACKR4 | Human | Ccl19 | 1 | Peptide | 8.5 | 8.8 | 9.1 | 8.4 | 8.4 | Refs | ||
B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Rat | Pacap-27 | 2 | Peptide | 7.6 | 8.5 | 9.4 | Refs | ||||
A (Rhodopsin) | Melanocortin | ACTHR | MC2 | Human | Acth | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Leukotriene | CLTR1 | CysLT1 | Human | Ltd4 | None | 1 | Small molecule | 7.3 | 8.6 | 9.4 | Refs | |||
A (Rhodopsin) | Cannabinoid | CNR1 | CB1 | Rat | 2-Arachidonoylglycerol | None | 1 | Small molecule | 6.3 | 6.8 | 7.2 | Refs | |||
A (Rhodopsin) | Somatostatin | SSR1 | SST1 | Human | Cst-17 | 1 | Peptide | 9.1 | 9.4 | 9.6 | Refs | ||||
A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Human | Pge2 | None | 5 | Small molecule | 5.5 | 5.5 | Refs | ||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | Human | Neuropeptide Sf | 3 | Peptide | ||||||||
B1 (Secretin) | Corticotropin-releasing factor | CRFR1 | CRF1 | Human | Urocortin 1 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Class A orphan | GP183 | GPR183 | Human | 25-Hydroxycholesterol | None | 6 | Small molecule | 6.9 | 6.9 | Refs | ||||
A (Rhodopsin) | Prostanoid | TA2R | TP | Human | Thromboxane A2 | 3 | Small molecule | ||||||||
C (Glutamate) | Metabotropic glutamate | GRM3 | mGlu3 | Human | Naag | None | 2 | Small molecule | 4.7 | 4.7 | Refs | ||||
A (Rhodopsin) | Adenosine | AA3R | A3 | Human | Adenosine | Principal | 1 | Small molecule | 6.5 | 6.5 | Refs | ||||
A (Rhodopsin) | Chemokine | ACKR1 | ACKR1 | Human | Ccl7 | Peptide | |||||||||
A (Rhodopsin) | Tachykinin | NK2R | NK2 | Human | Neuropeptide K | 4 | Peptide | ||||||||
A (Rhodopsin) | Opioid | OPRM | μ | Human | Β-Endorphin | 6 | Peptide | ||||||||
A (Rhodopsin) | Free fatty acid | FFAR1 | FFA1 | Human | Docosahexaenoic Acid | None | 1 | Small molecule | 5.4 | 5.7 | 6.0 | Refs | |||
A (Rhodopsin) | Complement peptide | C5AR1 | C5a1 | Human | C5a Des-Arg | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Complement peptide | C5AR1 | C5a1 | Human | C3a | 2 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW2 | NPBW2 | Human | Neuropeptide W-23 | 5 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW2 | NPBW2 | Human | Neuropeptide W-23 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Prostanoid | TA2R | TP | Human | Pgh2 | 3 | Small molecule | ||||||||
A (Rhodopsin) | Chemokine | ACKR4 | ACKR4 | Human | Ccl25 | 3 | Peptide | 7.9 | 8.1 | 8.3 | 7.6 | 7.6 | Refs | ||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl7 | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Histamine | HRH2 | H2 | Rat | Histamine | Principal | 1 | Small molecule | 3.8 | 3.8 | Refs | ||||
A (Rhodopsin) | Class A orphan | GP183 | GPR183 | Human | 7Α,27-Dihydroxycholesterol | None | 2 | Small molecule | 8.9 | 8.9 | Refs | ||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide B-23 | 5 | Peptide | ||||||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR6 | LPA6 | Human | Lpa | Principal | 1 | Small molecule | 6.0 | 6.0 | Refs | ||||
A (Rhodopsin) | Tachykinin | NK2R | NK2 | Human | Hemokinin 1 | 4 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Mouse | Pge2 | None | 1 | Small molecule | 9.4 | 9.4 | 9.1 | 9.1 | Refs | ||
A (Rhodopsin) | Formylpeptide | FPR3 | FPR3 | Human | Humanin | 1 | Peptide | 8.9 | 8.9 | Refs | |||||
A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Γ-Msh | 2 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Cxcl10 | 5 | Peptide | ||||||||
A (Rhodopsin) | Peptide P518 | QRFPR | QRFP | Human | Qrfp43 | 5 | Peptide | ||||||||
B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Phi | 4 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Human | Pancreatic Polypeptide | 2 | Peptide | 8.7 | 9.8 | 10.9 | Refs | ||||
A (Rhodopsin) | Adenosine | AA2AR | A2A | Human | Adenosine | Principal | 1 | Small molecule | 6.5 | 6.5 | Refs | ||||
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Mouse | Udp-Galactose | None | 1 | Small molecule | 7.6 | 7.6 | Refs | ||||
A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM3 | M3 | Human | Acetylcholine | Principal | 1 | Small molecule | 4.5 | 5.0 | 5.4 | Refs | |||
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Mouse | Udp-Glucose | None | 1 | Small molecule | 7.6 | 7.6 | Refs | ||||
A (Rhodopsin) | Prostanoid | PF2R | FP | Human | Pgi2 | 4 | Small molecule | ||||||||
A (Rhodopsin) | Class A orphan | GPR3 | GPR3 | Human | Sphingosine 1-Phosphate | Principal | 1 | Small molecule | 7.1 | 7.4 | 7.7 | Refs | |||
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Cxcl12Α | 7 | Peptide | 6.4 | 6.4 | Refs | |||||
A (Rhodopsin) | Chemokine | CX3C1 | CX3CR1 | Human | Cx3Cl1 | Principal | 1 | Peptide | Refs | ||||||
A (Rhodopsin) | Complement peptide | C3AR | C3a | Human | C3a | 2 | Peptide | ||||||||
A (Rhodopsin) | Complement peptide | C5AR2 | C5a2 | Human | C5a | 1 | Peptide | 8.9 | 8.9 | Refs | |||||
A (Rhodopsin) | Adren | ADA2C | α2C-adren | Human | (-)-Noradrenaline | None | 1 | Small molecule | 5.7 | 6.3 | 6.8 | Refs | |||
A (Rhodopsin) | Chemokine | ACKR3 | ACKR3 | Rat | Adrenomedullin | 2 | Peptide | 7.0 | 7.0 | Refs | |||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Prp106-126 | None | 8 | Peptide | 4.6 | 4.6 | Refs | ||||
A (Rhodopsin) | Dopamine | DRD5 | D5 | Human | 5-Hydroxytryptamine | None | 2 | Small molecule | 5.5 | 5.5 | Refs | ||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Desulfated Gastrin-34 | 5 | Peptide | ||||||||
A (Rhodopsin) | Endothelin | EDNRA | ETA | Human | Endothelin-2 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | XCR1 | XCR1 | Human | Xcl2 | 1 | Peptide | 7.3 | 7.3 | Refs | |||||
A (Rhodopsin) | Formylpeptide | FPR1 | FPR1 | Human | Cathepsin G | 2 | Peptide | ||||||||
A (Rhodopsin) | Adren | ADRB2 | β2-adren | Human | Noradrenaline | None | 2 | Small molecule | 5.4 | 5.4 | Refs | ||||
A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Human | Pge1 | None | 1 | Small molecule | 8.0 | 8.0 | Refs | ||||
A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Human | Ltc4 | None | 2 | Small molecule | 7.8 | 9.1 | 9.1 | Refs | |||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl3 | 8 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide Y | NPY2R | Y2 | Human | Pancreatic Polypeptide | 5 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | Human | Neuropeptide Ff | 1 | Peptide | 9.7 | 9.7 | Refs | |||||
A (Rhodopsin) | Prostanoid | TA2R | TP | Human | Pgd2 | 3 | Small molecule | ||||||||
A (Rhodopsin) | Adren | ADRB3 | β3-adren | Mouse | (+)-Adrenaline | None | 1 | Small molecule | |||||||
A (Rhodopsin) | Opioid | OPRD | δ | Human | Dynorphin B | 4 | Peptide | 7.8 | 7.8 | Refs | |||||
A (Rhodopsin) | Prokineticin | PKR2 | PKR2 | Human | Prokineticin-2 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemerin | CML2 | hemerin receptor 2 | Human | Chemerin | Principal | 1 | Peptide | 8.8 | 9.2 | 9.6 | Refs | |||
B2 (Adhesion) | ADGRB | AGRB1 | ADGRB1 | Human | Phosphatidylserine | Principal | 1 | Small molecule | Refs | ||||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Neuropeptide Sf | 3 | Peptide | ||||||||
A (Rhodopsin) | Melanocortin | MC3R | MC3 | Human | Β-Msh | 3 | Peptide | ||||||||
A (Rhodopsin) | Melanocortin | MC3R | MC3 | Human | Β-Msh | 3 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl5 | 7 | Peptide | ||||||||
A (Rhodopsin) | Relaxin family peptide | RXFP1 | RXFP1 | Human | Relaxin | 1 | Peptide | 10.4 | 10.4 | 9.2 | 9.7 | 10.2 | Refs | ||
B1 (Secretin) | Glucagon receptor family | GLP1R | GLP-1 | Human | Glucagon | 2 | Peptide | 6.9 | 7.0 | 7.0 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl4 | 1 | Peptide | 9.4 | 9.5 | 9.6 | Refs | ||||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR2 | S1P2 | Human | Dihydrosphingosine 1-Phosphate | 2 | Small molecule | ||||||||
A (Rhodopsin) | Opioid | OPRD | δ | Human | Α-Neoendorphin | 7 | Peptide | Refs | |||||||
A (Rhodopsin) | Somatostatin | SSR4 | SST4 | Human | Cortistatin-14 | 4 | Peptide | ||||||||
A (Rhodopsin) | Formylpeptide | FPR1 | FPR1 | Human | Annexin I | 2 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Neuropeptide Af | 3 | Peptide | ||||||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Serum Amyloid A | 6 | Peptide | 6.6 | 6.6 | Refs | |||||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl2 | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl8 | 8 | Peptide | ||||||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Gastrin-71 | 5 | Peptide | ||||||||
A (Rhodopsin) | Galanin | GALR3 | GAL3 | Human | Galanin | 2 | Peptide | 7.2 | 7.2 | Refs | |||||
B1 (Secretin) | Calcitonin | CALCR | CT | Human | Adrenomedullin 2/Intermedin | 6 | Peptide | 6.5 | 6.5 | Refs | |||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR3 | LPA3 | Human | Farnesyl Diphosphate | None | 2 | Small molecule | Refs | ||||||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl5 | 3 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCRL2 | CCRL2 | Human | Chemerin C-Terminal Peptide | 2 | Peptide | ||||||||
A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Human | Large Neurotensin | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Class A orphan | MRGX2 | MRGPRX2 | Human | Pamp-20 | Principal | 1 | Peptide | Refs | ||||||
A (Rhodopsin) | Formylpeptide | FPR1 | FPR1 | Human | Cathepsin G | 2 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Mouse | Pgd3 | None | 3 | Small molecule | 7.4 | 7.4 | Refs | ||||
A (Rhodopsin) | Adren | ADRB3 | β3-adren | Rat | (-)-Adrenaline | None | 1 | Small molecule | |||||||
A (Rhodopsin) | Leukotriene | OXER1 | OXE | Human | 5-Oxo-12-Hete | None | 7 | Small molecule | Refs | ||||||
A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Human | Bradykinin | 5 | Peptide | 5.1 | 5.2 | 5.3 | Refs | ||||
A (Rhodopsin) | Urotensin | UR2R | UT | Mouse | Urotensin-Ii | 3 | Peptide | 8.4 | 8.5 | 8.6 | Refs | ||||
A (Rhodopsin) | Opioid | OPRK | κ | Rat | Dynorphin A-(1-13) | 2 | Peptide | 9.3 | 9.9 | 9.9 | Refs | ||||
A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Rat | Pancreatic Polypeptide | 1 | Peptide | 10.3 | 10.6 | 10.8 | Refs | ||||
A (Rhodopsin) | Prokineticin | PKR1 | PKR1 | Human | Prokineticin-1 | 4 | Peptide | ||||||||
A (Rhodopsin) | Leukotriene | OXER1 | OXE | Human | 5-Oxo-Ode | None | 2 | Small molecule | 8.0 | 8.0 | Refs | ||||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl5 | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Gonadotrophin-releasing hormone | GNRHR | GnRH1 | Human | Gnrh Ii | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Desulfated Gastrin-14 | 5 | Peptide | ||||||||
F (Frizzled) | Frizzled | FZD1 | FZD1 | Human | Wnt-3a | Peptide | |||||||||
A (Rhodopsin) | Galanin | GALR1 | GAL1 | Rat | Galanin-Like Peptide | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Free fatty acid | FFAR4 | FFA4 | Human | Oleic Acid | None | 4 | Small molecule | 4.7 | 4.7 | Refs | ||||
C (Glutamate) | GABAB | GABR1 | GABAB1 | Human | Gaba | Principal | 1 | Small molecule | |||||||
A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl11 | Peptide | |||||||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Gastrin-17 | 5 | Peptide | ||||||||
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Rat | Udp-Glucose | None | 1 | Small molecule | 7.6 | 7.6 | Refs | ||||
A (Rhodopsin) | Class A orphan | GPR37 | GPR37 | Human | Prosaptide | Principal | 1 | Peptide | 8.1 | 8.1 | Refs | ||||
A (Rhodopsin) | Relaxin family peptide | Q5Y986 | RXFP3 | Rat | Relaxin-3 | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Endothelin | EDNRB | ETB | Human | Endothelin-1 | 2 | Peptide | ||||||||
B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Human | Pthrp-(1-36) | 4 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl8 | 5 | Peptide | ||||||||
A (Rhodopsin) | Complement peptide | C3AR | C3a | Human | C5a | 2 | Peptide | ||||||||
A (Rhodopsin) | Melanocortin | MC4R | MC4 | Human | Acth | 3 | Peptide | ||||||||
A (Rhodopsin) | Neuromedin U | NMUR2 | NMU2 | Human | Neuromedin U-23 | 3 | Peptide | ||||||||
B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Phv | 4 | Peptide | ||||||||
B1 (Secretin) | Parathyroid hormone | PTH1R | PTH1 | Human | Pthrp-(1-36) | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Somatostatin | SSR3 | SST3 | Human | Cortistatin-14 | 4 | Peptide | ||||||||
Other GPCRs | Other GPCR orphan | GP107 | GPR107 | Human | Neuronostatin | Principal | 1 | Peptide | |||||||
B1 (Secretin) | Parathyroid hormone | PTH1R | PTH1 | Human | Pthrp | 3 | Peptide | ||||||||
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Phm | 4 | Peptide | 5.7 | 5.7 | Refs | |||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl23 | 2 | Peptide | 8.9 | 8.9 | Refs | |||||
A (Rhodopsin) | Melanocortin | MC4R | MC4 | Human | Agouti-Related Protein | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Endothelin | EDNRA | ETA | Human | Endothelin-3 | 3 | Peptide | ||||||||
A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Rat | Neurotensin | 1 | Peptide | 8.8 | 8.8 | Refs | |||||
A (Rhodopsin) | Neuropeptide S | NPSR1 | NPS | Human | Neuropeptide S | Principal | 1 | Peptide | |||||||
C (Glutamate) | Metabotropic glutamate | GRM7 | mGlu7 | Human | L-Serine-O-Phosphate | None | 1 | Small molecule | 4.5 | 4.5 | 4.4 | 4.4 | Refs | ||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl1 | 3 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GPR32 | GPR32 | Human | Lxa4 | None | 2 | Small molecule | 9.7 | 9.7 | Refs | ||||
A (Rhodopsin) | Neuropeptide Y | NPY5R | Y5 | Human | Pyy-(3-36) | 3 | Peptide | 8.4 | 8.4 | Refs | |||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | Human | Neuropeptide Af | 3 | Peptide | ||||||||
A (Rhodopsin) | Prokineticin | PKR1 | PKR1 | Human | Prokineticin-1 | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Prokineticin | PKR2 | PKR2 | Human | Prokineticin-1 | 4 | Peptide | ||||||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Annexin I | 9 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Mouse | Pge2 | None | 5 | Small molecule | 5.5 | 5.5 | Refs | ||||
A (Rhodopsin) | Proteinase-activated | PAR1 | PAR1 | Human | Thrombin | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide B-23 | 5 | Peptide | ||||||||
A (Rhodopsin) | Endothelin | EDNRA | ETA | Human | Endothelin-2 | 3 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | ACKR1 | ACKR1 | Human | Ccl17 | Peptide | |||||||||
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Mouse | Pgd2 | None | 3 | Small molecule | 7.9 | 7.9 | 5.9 | 7.4 | 8.9 | Refs | |
A (Rhodopsin) | Complement peptide | C5AR1 | C5a1 | Human | Ribosomal Protein S19 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemerin | CML1 | hemerin | Human | Chemerin C-Terminal Peptide | None | 2 | Peptide | |||||||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR5 | S1P5 | Human | Dihydrosphingosine 1-Phosphate | 2 | Small molecule | ||||||||
A (Rhodopsin) | Complement peptide | C3AR | C3a | Human | C5a | 2 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | TAAR2 | TAAR2 | Human | Tryptamine | Small molecule | |||||||||
A (Rhodopsin) | Kisspeptin | KISSR | kisspeptin | Human | Kisspeptin-13 | 4 | Peptide | 8.4 | 8.4 | Refs | |||||
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Human | Udp | None | 2 | Small molecule | 7.1 | 7.1 | Refs | ||||
A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl7 | Peptide | |||||||||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl11 | 8 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GPR63 | GPR63 | Human | Dihydrosphingosine 1-Phosphate | None | 2 | Small molecule | 6.2 | 6.2 | Refs | ||||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR1 | S1P1 | Human | Dihydrosphingosine 1-Phosphate | 2 | Small molecule | ||||||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl3 | 7 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Human | Ltd4 | None | 3 | Small molecule | 8.1 | 8.3 | 8.4 | Refs | |||
A (Rhodopsin) | Endothelin | EDNRB | ETB | Human | Endothelin-2 | 2 | Peptide | ||||||||
C (Glutamate) | Metabotropic glutamate | GRM5 | mGlu5 | Rat | L-Glutamic Acid | Principal | 1 | Small molecule | 5.0 | 5.3 | 5.5 | Refs | |||
A (Rhodopsin) | Opioid | OPRM | μ | Human | Β-Endorphin | 6 | Peptide | ||||||||
C (Glutamate) | GABAB | GABR1 | GABAB1 | Rat | Gaba | Principal | 1 | Small molecule | Refs | ||||||
A (Rhodopsin) | Adren | ADRB3 | β3-adren | Mouse | (-)-Adrenaline | None | 1 | Small molecule | |||||||
C (Glutamate) | Class C Orphan | GPC6A | GPRC6 | Human | L-Serine | None | 5 | Small molecule | 3.2 | 3.2 | Refs | ||||
A (Rhodopsin) | Hydroxycarboxylic acid | HCAR3 | HCA3 | Human | 3-Hydroxyoctanoic Acid | Principal | 1 | Small molecule | 5.1 | 5.1 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl26 | 5 | Peptide | Refs | |||||||
A (Rhodopsin) | Galanin | GALR2 | GAL2 | Human | Galanin-Like Peptide | 4 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | Human | Qrfp43 (43rfa) | 3 | Peptide | ||||||||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR1 | S1P1 | Human | Sphingosylphosphorylcholine | 2 | Small molecule | ||||||||
A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Human | Pyy-(3-36) | 6 | Peptide | 6.2 | 6.2 | Refs | |||||
A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Human | Large Neuromedin N | 3 | Peptide | ||||||||
A (Rhodopsin) | GPR18, GPR55 and GPR119 | GPR55 | GPR55 | Human | 2-Arachidonoylglycerolphosphoinositol | None | 5 | Small molecule | Refs | ||||||
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Secretin | 4 | Peptide | ||||||||
A (Rhodopsin) | Leukotriene | LT4R2 | BLT2 | Human | 20-Hydroxy-Ltb4 | 4 | Small molecule | ||||||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR6 | LPA6 | Mouse | Lpa | Principal | 1 | Small molecule | 6.0 | 6.0 | Refs | ||||
A (Rhodopsin) | Complement peptide | C3AR | C3a | Human | C3a | 1 | Peptide | 7.3 | 8.5 | 9.6 | Refs | ||||
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Cxcl10 | 9 | Peptide | ||||||||
A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Human | Neuromedin N | 2 | Peptide | 8.7 | 8.7 | Refs | |||||
A (Rhodopsin) | Chemokine | CCRL2 | CCRL2 | Human | Ccl19 | 1 | Peptide | Refs | |||||||
B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Human | Pthrp-(1-34) (Human) | None | 3 | Peptide | Refs | ||||||
B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Human | Urocortin 3 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | CCR8 | CCR8 | Human | Ccl1 | 2 | Peptide | ||||||||
A (Rhodopsin) | GPR18, GPR55 and GPR119 | GP119 | GPR119 | Human | Sea | None | 2 | Small molecule | |||||||
A (Rhodopsin) | Prostanoid | TA2R | TP | Human | Pgi2 | 3 | Small molecule | ||||||||
A (Rhodopsin) | Relaxin family peptide | RXFP2 | RXFP2 | Human | Relaxin-3 | 2 | Peptide | 7.0 | 7.0 | Refs | |||||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl13 | 2 | Peptide | Refs | |||||||
B1 (Secretin) | Calcitonin | CALCR | CT | Human | Calcitonin | 7 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | P2Y10 | P2RY10 | Human | Sphingosine 1-Phosphate | None | 1 | Small molecule | 7.3 | 7.3 | Refs | ||||
A (Rhodopsin) | Tachykinin | NK1R | NK1 | Human | Neurokinin B | 3 | Peptide | 6.1 | 6.3 | 6.4 | Refs | ||||
A (Rhodopsin) | Class A orphan | GPR31 | GPR31 | Mouse | 12s-Hete | Principal | 1 | Small molecule | 9.6 | 9.6 | Refs | ||||
A (Rhodopsin) | Neuropeptide Y | NPY4R | Y4 | Rat | Pyy-(3-36) | 6 | Peptide | 6.2 | 6.2 | Refs | |||||
A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Human | Pgi2 | 6 | Small molecule | ||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl7 | 5 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl15 | 5 | Peptide | Refs | |||||||
A (Rhodopsin) | Class A orphan | GP183 | GPR183 | Human | 7Β-Hydroxycholesterol | None | 7 | Small molecule | 5.8 | 5.8 | Refs | ||||
A (Rhodopsin) | Leukotriene | OXER1 | OXE | Human | 5-Oxo-C20:3 | None | 2 | Small molecule | 8.0 | 8.0 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR4 | CCR4 | Human | Ccl22 | 3 | Peptide | ||||||||
C (Glutamate) | Metabotropic glutamate | GRM5 | mGlu5 | Human | L-Glutamic Acid | Principal | 1 | Small molecule | 5.0 | 5.3 | 5.5 | Refs | |||
A (Rhodopsin) | Melanocortin | MSHR | MC1 | Human | Γ-Msh | 2 | Peptide | ||||||||
A (Rhodopsin) | GPR18, GPR55 and GPR119 | GP119 | GPR119 | Human | Anandamide | 2 | Small molecule | ||||||||
A (Rhodopsin) | Melanocortin | MC4R | MC4 | Human | Β-Msh | 3 | Peptide | ||||||||
A (Rhodopsin) | Melanocortin | MSHR | MC1 | Human | Acth | 2 | Peptide | ||||||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1B | 5-HT1B | Human | 5-Ht-Moduline | None | 3 | Peptide | Refs | ||||||
F (Frizzled) | Frizzled | FZD4 | FZD4 | Mouse | Norrin | Principal | 1 | Peptide | Refs | ||||||
A (Rhodopsin) | Ghrelin | GHSR | ghrelin | Human | Ghrelin | 2 | Peptide | ||||||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR1 | LPA1 | Mouse | Lpa | Principal | 1 | Small molecule | 7.9 | 8.1 | 8.3 | Refs | |||
C (Glutamate) | Metabotropic glutamate | GRM7 | mGlu7 | Human | L-Glutamic Acid | None | 2 | Small molecule | 3.0 | 3.0 | 3.1 | 3.1 | Refs | ||
A (Rhodopsin) | Opioid | OPRM | μ | Human | Dynorphin A-(1-13) | 4 | Peptide | 8.3 | 8.3 | Refs | |||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide W-30 | 5 | Peptide | ||||||||
A (Rhodopsin) | Leukotriene | LT4R2 | BLT2 | Human | 12-Epi Ltb4 | None | 2 | Small molecule | 7.5 | 7.5 | Refs | ||||
C (Glutamate) | Metabotropic glutamate | GRM6 | mGlu6 | Human | L-Serine-O-Phosphate | None | 1 | Small molecule | 6.4 | 6.4 | Refs | ||||
A (Rhodopsin) | Neuropeptide Y | NPY5R | Y5 | Human | Neuropeptide Y | 1 | Peptide | 9.1 | 9.1 | Refs | |||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl8 | 5 | Peptide | ||||||||
A (Rhodopsin) | Neuromedin U | NMUR2 | NMU2 | Human | Neuromedin S-33 | 1 | Peptide | 10.0 | 10.0 | Refs | |||||
A (Rhodopsin) | Galanin | GALR1 | GAL1 | Human | Galanin-Like Peptide | 2 | Peptide | ||||||||
A (Rhodopsin) | GPR18, GPR55 and GPR119 | GPR55 | GPR55 | Human | 2-Arachidonoylglycerol | None | 1 | Small molecule | 8.5 | 8.5 | Refs | ||||
A (Rhodopsin) | Relaxin family peptide | RL3R2 | RXFP4 | Human | Relaxin-3 (B Chain) | 4 | Peptide | 7.0 | 7.0 | Refs | |||||
F (Frizzled) | Frizzled | FZD1 | FZD1 | Human | Wnt-7b | Peptide | |||||||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl5 | 4 | Peptide | 6.8 | 7.5 | 8.2 | Refs | ||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Gastrin-34 | 5 | Peptide | ||||||||
A (Rhodopsin) | Bradykinin | BKRB2 | B2 | Human | T-Kinin | 3 | Peptide | ||||||||
A (Rhodopsin) | Melanocortin | MC3R | MC3 | Human | Acth | 2 | Peptide | 7.1 | 7.1 | Refs | |||||
A (Rhodopsin) | Formylpeptide | FPR3 | FPR3 | Human | F2l | 2 | Peptide | 8.0 | 8.1 | 8.2 | Refs | ||||
A (Rhodopsin) | Ghrelin | GHSR | ghrelin | Human | [Des-Gln14]Ghrelin | 2 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl5 | Peptide | |||||||||
B1 (Secretin) | Glucagon receptor family | GLP1R | GLP-1 | Human | Glucagon-Like Peptide 1-(7-36) Amide | 1 | Peptide | 9.2 | 9.2 | Refs | |||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Ll-37 | 7 | Peptide | 6.0 | 6.0 | Refs | |||||
A (Rhodopsin) | Proteinase-activated | PAR4 | PAR4 | Human | Cathepsin G | Peptide | |||||||||
A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl3 | Peptide | |||||||||
B1 (Secretin) | Glucagon receptor family | GLP2R | GLP-2 | Human | Glucagon-Like Peptide 2-(3-33) | 4 | Peptide | Refs | |||||||
A (Rhodopsin) | Class A orphan | LGR4 | LGR4 | Human | R-Spondin-1 | 2 | Peptide | 10.7 | 10.7 | Refs | |||||
A (Rhodopsin) | Bombesin | NMBR | BB1 | Human | Gastrin Releasing Peptide(14-27) (Human) | None | 2 | Peptide | Refs | ||||||
A (Rhodopsin) | Class A orphan | GPR31 | GPR31 | Human | 12s-Hete | Principal | 1 | Small molecule | |||||||
F (Frizzled) | Frizzled | FZD6 | FZD6 | Human | Wnt-5a | Peptide | Refs | ||||||||
B1 (Secretin) | VIP and PACAP | VIPR2 | VPAC2 | Human | Secretin | 4 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl11 | 5 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | XCR1 | XCR1 | Human | Xcl1 | 2 | Peptide | ||||||||
A (Rhodopsin) | Adren | ADRB1 | β1-adren | Human | Noradrenaline | None | 1 | Small molecule | 6.0 | 6.0 | Refs | ||||
A (Rhodopsin) | Complement peptide | C5AR1 | C5a1 | Human | C5a | 2 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW2 | NPBW2 | Human | Neuropeptide W-30 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Prostanoid | PI2R | IP | Human | Pge2 | 3 | Small molecule | ||||||||
A (Rhodopsin) | Melanocortin | MC3R | MC3 | Human | Γ-Msh | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Prostanoid | PD2R | DP1 | Human | Pgi2 | 6 | Small molecule | ||||||||
A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM1 | M1 | Rat | Acetylcholine | Principal | 1 | Small molecule | 4.3 | 4.6 | 4.9 | Refs | |||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl16 | 8 | Peptide | ||||||||
B2 (Adhesion) | ADGRL | AGRL3 | ADGRL3 | Rat | Flrt3 | Principal | 1 | Peptide | Refs | ||||||
A (Rhodopsin) | Chemokine | CXCR4 | CXCR4 | Human | Cxcl12Δ | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Opioid | OPRM | μ | Human | Endomorphin-2 | 6 | Peptide | ||||||||
A (Rhodopsin) | Platelet-activating factor | PTAFR | PAF | Human | Paf | Principal | 1 | Small molecule | 7.5 | 7.7 | 7.9 | Refs | |||
A (Rhodopsin) | Neuromedin U | NMUR1 | NMU1 | Human | Neuromedin U-23 | 3 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | TAAR3 | TAAR3 | Mouse | Isoamylamine | Principal | 1 | Small molecule | 5.0 | 5.0 | Refs | ||||
A (Rhodopsin) | Proteinase-activated | PAR3 | PAR3 | Human | Thrombin | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW2 | NPBW2 | Human | Neuropeptide B-23 | 5 | Peptide | ||||||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Humanin | 4 | Peptide | 8.5 | 8.5 | Refs | |||||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR2 | S1P2 | Human | Sphingosylphosphorylcholine | 2 | Small molecule | ||||||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR4 | LPA4 | Human | Lpa | None | 1 | Small molecule | Refs | ||||||
A (Rhodopsin) | Prostanoid | PD2R | DP1 | Human | Pge1 | None | 3 | Small molecule | 7.3 | 7.3 | Refs | ||||
A (Rhodopsin) | Opioid | OPRK | κ | Human | Β-Neoendorphin | 4 | Peptide | 9.1 | 9.1 | Refs | |||||
A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Desulfated Cholecystokinin-8 | 2 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PI2R | IP | Human | Pgf2Α | 3 | Small molecule | ||||||||
A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Human | Neuromedin N | 2 | Peptide | ||||||||
A (Rhodopsin) | Apelin | APJ | apelin | Human | Apelin-17 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Bombesin | NMBR | BB1 | Human | Gastrin-Releasing Peptide | 2 | Peptide | ||||||||
A (Rhodopsin) | Apelin | APJ | apelin | Human | Apelin-36 | 2 | Peptide | Refs | |||||||
C (Glutamate) | Class C Orphan | GPC6A | GPRC6 | Human | L-Citrulline | None | 4 | Small molecule | 3.6 | 3.6 | Refs | ||||
A (Rhodopsin) | Bombesin | NMBR | BB1 | Human | Grp-(18-27) | 2 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl13 | 4 | Peptide | 9.1 | 9.1 | Refs | |||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl2 | 8 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | GPR34 | GPR34 | Mouse | Lysophosphatidylserine | Principal | 1 | Small molecule | 6.6 | 7.3 | 7.3 | Refs | |||
A (Rhodopsin) | Melanocortin | MC3R | MC3 | Human | Α-Msh | 1 | Peptide | 8.0 | 8.2 | 8.4 | Refs | ||||
A (Rhodopsin) | Angiotensin | AGTR2 | AT2 | Human | Angiotensin Ii | 2 | Peptide | ||||||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Cck-39 | 5 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide Y | Q9ERC0 | Y2 | Rat | Peptide Yy | 1 | Peptide | 10.0 | 10.0 | Refs | |||||
A (Rhodopsin) | Prostanoid | TA2R | TP | Human | Pge2 | None | 2 | Small molecule | 4.5 | 4.5 | Refs | ||||
A (Rhodopsin) | Neurotensin | NTR2 | NTS2 | Mouse | Xenin | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Apelin | APJ | apelin | Human | Elabela/Toddler-32 | 2 | Peptide | ||||||||
A (Rhodopsin) | Neuromedin U | NMUR1 | NMU1 | Human | Neuromedin S-36 | 3 | Peptide | ||||||||
A (Rhodopsin) | Bombesin | NMBR | BB1 | Human | Gastrin-Releasing Peptide | 2 | Peptide | ||||||||
B1 (Secretin) | Glucagon receptor family | SCTR | secretin | Rat | Vip | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide B-23 | 5 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl2 | 5 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl2 | 8 | Peptide | ||||||||
A (Rhodopsin) | P2Y | P2RY6 | P2Y6 | Human | Udp | None | 1 | Small molecule | 6.5 | 6.5 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Cxcl9 | 5 | Peptide | ||||||||
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Ghrh | 4 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PE2R2 | EP2 | Human | Thromboxane A2 | 5 | Small molecule | ||||||||
A (Rhodopsin) | Adren | ADRB3 | β3-adren | Human | (-)-Adrenaline | None | 3 | Small molecule | 3.9 | 3.9 | Refs | ||||
A (Rhodopsin) | Complement peptide | C5AR1 | C5a1 | Human | C5a | 2 | Peptide | ||||||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Aspirin Triggered Lipoxin A4 | None | 9 | Small molecule | |||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl28 | 5 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl2 | 5 | Peptide | ||||||||
A (Rhodopsin) | Glycoprotein hormone | LSHR | LH | Human | Lh | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Acth | 1 | Peptide | 5.0 | 5.0 | Refs | |||||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR5 | S1P5 | Human | Sphingosylphosphorylcholine | 2 | Small molecule | ||||||||
A (Rhodopsin) | Endothelin | EDNRB | ETB | Rat | Endothelin-3 | 1 | Peptide | Refs | |||||||
A (Rhodopsin) | P2Y | P2RY1 | P2Y1 | Human | Adp | None | 2 | Small molecule | Refs | ||||||
A (Rhodopsin) | Chemokine | CCR6 | CCR6 | Human | Ccl20 | 2 | Peptide | ||||||||
B1 (Secretin) | Glucagon receptor family | GLP2R | GLP-2 | Rat | Glucagon-Like Peptide 2-(3-33) | 2 | Peptide | 6.6 | 6.6 | Refs | |||||
Other GPCRs | Other GPCR orphan | GP143 | GPR143 | Human | Levodopa | Principal | 1 | Small molecule | Refs | ||||||
A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Human | Octopamine | None | 4 | Small molecule | |||||||
A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl8 | Peptide | |||||||||
A (Rhodopsin) | Trace amine | TAAR1 | TA1 | Human | 3-Iodothyronamine | None | 1 | Small molecule | |||||||
A (Rhodopsin) | Endothelin | EDNRB | ETB | Human | Endothelin-2 | 2 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | P2Y10 | P2RY10 | Human | Lpa | None | 2 | Small molecule | 6.9 | 6.9 | Refs | ||||
A (Rhodopsin) | Prokineticin | PKR2 | PKR2 | Human | Prokineticin-1 | 4 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | ACKR1 | ACKR1 | Human | Cxcl8 | Peptide | |||||||||
F (Frizzled) | Frizzled | FZD1 | FZD1 | Human | Wnt-1 | Peptide | |||||||||
A (Rhodopsin) | Angiotensin | AGTR1 | AT1 | Human | Angiotensin Ii | 3 | Peptide | ||||||||
A (Rhodopsin) | Tachykinin | NK2R | NK2 | Human | Neuropeptide Γ | 4 | Peptide | ||||||||
A (Rhodopsin) | Opioid | OPRD | δ | Human | Β-Endorphin | 7 | Peptide | ||||||||
A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Cck-33 | 2 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR6 | CCR6 | Human | Ccl20 | 2 | Peptide | ||||||||
A (Rhodopsin) | Endothelin | EDNRA | ETA | Human | Endothelin-1 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Kisspeptin | KISSR | kisspeptin | Human | Kisspeptin-52 | 5 | Peptide | ||||||||
A (Rhodopsin) | Relaxin family peptide | RXFP2 | RXFP2 | Human | Relaxin-1 | 2 | Peptide | 8.8 | 8.8 | Refs | |||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Gastrin-14 | 5 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Human | Pgd2 | None | 3 | Small molecule | 7.9 | 7.9 | 5.9 | 7.4 | 8.9 | Refs | |
A (Rhodopsin) | Class A orphan | GPR32 | GPR32 | Human | Resolvin D1 | None | 1 | Small molecule | 11.1 | 11.1 | Refs | ||||
A (Rhodopsin) | Neuropeptide Y | NPY5R | Y5 | Rat | Peptide Yy | 2 | Peptide | 9.0 | 9.0 | Refs | |||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl7 | 8 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Rfrp-1 | 3 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl17 | Peptide | |||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl7 | 5 | Peptide | ||||||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Mouse | Cramp | 5 | Peptide | 6.7 | 6.9 | 7.0 | Refs | ||||
A (Rhodopsin) | Relaxin family peptide | RXFP2 | RXFP2 | Human | Insl3 | 2 | Peptide | 9.3 | 9.5 | 9.7 | Refs | ||||
A (Rhodopsin) | Orexin | OX2R | OX2 | Human | Orexin-B | 2 | Peptide | ||||||||
A (Rhodopsin) | Proteinase-activated | PAR4 | PAR4 | Human | Thrombin | Peptide | |||||||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl7 | 6 | Peptide | 7.5 | 7.5 | Refs | |||||
B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Human | Pth | 5 | Peptide | ||||||||
A (Rhodopsin) | P2Y | P2RY6 | P2Y6 | Human | Utp | None | 2 | Small molecule | 5.2 | 5.2 | Refs | ||||
A (Rhodopsin) | Chemokine | CXCR4 | CXCR4 | Human | Cxcl12Φ | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Desulfated Gastrin-71 | 5 | Peptide | ||||||||
B2 (Adhesion) | ADGRL | AGRL1 | ADGRL1 | Rat | Lasso D | Principal | 1 | Peptide | Refs | ||||||
A (Rhodopsin) | Adren | ADRB3 | β3-adren | Human | (+)-Adrenaline | None | 1 | Small molecule | |||||||
A (Rhodopsin) | Neuropeptide Y | NPY5R | Y5 | Rat | Neuropeptide Y | 1 | Peptide | 9.1 | 9.1 | Refs | |||||
A (Rhodopsin) | Proteinase-activated | PAR3 | PAR3 | Human | Thrombin | Principal | 1 | Peptide | |||||||
B1 (Secretin) | Glucagon receptor family | GLP2R | GLP-2 | Rat | Glucagon-Like Peptide 2-(2-33) | 3 | Peptide | 6.1 | 6.1 | Refs | |||||
A (Rhodopsin) | Prostanoid | PE2R1 | EP1 | Human | Thromboxane A2 | 6 | Small molecule | ||||||||
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Secretin | 4 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR7 | CCR7 | Mouse | Ccl21a | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Class A orphan | GPR6 | GPR6 | Human | Sphingosine 1-Phosphate | Principal | 1 | Small molecule | |||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide B-29 | 3 | Peptide | Refs | |||||||
B1 (Secretin) | Parathyroid hormone | PTH1R | PTH1 | Human | Tip39 | 1 | Peptide | Refs | |||||||
C (Glutamate) | Class C Orphan | GPC6A | GPRC6 | Human | L-Alanine | None | 3 | Small molecule | 3.8 | 3.8 | Refs | ||||
A (Rhodopsin) | Estrogen (G protein-coupled) | GPER1 | GPER | Human | 17Β-Estradiol | Principal | 1 | Small molecule | 8.2 | 8.4 | 8.5 | Refs | |||
A (Rhodopsin) | Chemokine | CCR9 | CCR9 | Human | Ccl25 | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Tachykinin | NK1R | NK1 | Human | Neuropeptide K | 4 | Peptide | Refs | |||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW2 | NPBW2 | Human | Neuropeptide B-23 | 4 | Peptide | Refs | |||||||
A (Rhodopsin) | Class A orphan | GPR17 | GPR17 | Human | Atp | None | 4 | Small molecule | 7.4 | 7.4 | Refs | ||||
A (Rhodopsin) | Neuropeptide Y | NPY1R | Y1 | Human | Peptide Yy | 4 | Peptide | ||||||||
A (Rhodopsin) | Kisspeptin | KISSR | kisspeptin | Human | Kisspeptin-54 | 2 | Peptide | 8.8 | 9.2 | 9.5 | Refs | ||||
A (Rhodopsin) | Opioid | OPRM | μ | Human | [Leu]Enkephalin | 5 | Peptide | 8.1 | 8.1 | Refs | |||||
A (Rhodopsin) | Neuropeptide Y | NPY5R | Y5 | Rat | Pyy-(3-36) | 3 | Peptide | 8.4 | 8.4 | Refs | |||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Annexin I | 9 | Peptide | Refs | |||||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Gastrin-17 | 5 | Peptide | ||||||||
A (Rhodopsin) | Leukotriene | LT4R2 | BLT2 | Human | 15s-Hete | None | 2 | Small molecule | 7.5 | 7.5 | Refs | ||||
A (Rhodopsin) | Neurotensin | NTR1 | NTS1 | Human | Neuromedin N | 3 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide Y | NPY5R | Y5 | Human | Pancreatic Polypeptide | 4 | Peptide | 8.0 | 8.0 | Refs | |||||
A (Rhodopsin) | Opioid | OPRM | μ | Human | Dynorphin B | 2 | Peptide | 8.5 | 8.5 | Refs | |||||
A (Rhodopsin) | Neuropeptide Y | NPY1R | Y1 | Rat | Pancreatic Polypeptide | 3 | Peptide | 7.0 | 7.0 | Refs | |||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl4 | 8 | Peptide | ||||||||
A (Rhodopsin) | Dopamine | DRD4 | D4 | Rat | Dopamine | Principal | 1 | Small molecule | 7.4 | 7.4 | Refs | ||||
A (Rhodopsin) | Neuromedin U | NMUR2 | NMU2 | Human | Neuromedin S-36 | 3 | Peptide | ||||||||
A (Rhodopsin) | Peptide P518 | QRFPR | QRFP | Rat | Qrfp26 | 5 | Peptide | Refs | |||||||
A (Rhodopsin) | Somatostatin | SSR1 | SST1 | Human | Cortistatin-14 | 4 | Peptide | ||||||||
A (Rhodopsin) | Opioid | OPRK | κ | Rat | Dynorphin A | 1 | Peptide | 10.0 | 10.2 | 10.3 | Refs | ||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Ltd4 | 9 | Small molecule | ||||||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Neuropeptide Af | 3 | Peptide | ||||||||
A (Rhodopsin) | Kisspeptin | KISSR | kisspeptin | Human | Kisspeptin-10 | 1 | Peptide | 8.6 | 9.5 | 10.4 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl4 | 7 | Peptide | ||||||||
A (Rhodopsin) | Melanocortin | MSHR | MC1 | Human | Β-Msh | 2 | Peptide | ||||||||
A (Rhodopsin) | Adenosine | AA1R | A1 | Human | Adenosine | Principal | 1 | Small molecule | 7.0 | 7.0 | Refs | ||||
A (Rhodopsin) | Neuropeptide Y | NPY2R | Y2 | Human | Pancreatic Polypeptide | 5 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Cxcl11 | 5 | Peptide | ||||||||
B1 (Secretin) | Corticotropin-releasing factor | CRFR2 | CRF2 | Human | Urocortin 1 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Formylpeptide | FPR2 | FPR2/ALX | Human | Aspirin-Triggered Resolvin D1 | None | 3 | Small molecule | 11.1 | 11.1 | Refs | ||||
A (Rhodopsin) | Chemokine | CXCR4 | CXCR4 | Human | Cxcl12Β | 2 | Peptide | Refs | |||||||
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Rat | Phv | 4 | Peptide | Refs | |||||||
A (Rhodopsin) | Class A orphan | GP182 | GPR182 | Rat | Adrenomedullin | Principal | 1 | Peptide | 8.1 | 8.1 | Refs | ||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW2 | NPBW2 | Human | Neuropeptide B-29 | 5 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Cxcl11 | 1 | Peptide | 10.4 | 10.5 | 10.5 | Refs | ||||
A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Gastrin-17 | 2 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl11 | 8 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CXCR1 | CXCR1 | Human | Cytokine Domain Of Tyrosyl Trna Synthetase | 3 | Peptide | ||||||||
A (Rhodopsin) | P2Y | P2Y14 | P2Y14 | Human | Udp-Glucuronic Acid | None | 3 | Small molecule | |||||||
A (Rhodopsin) | Chemokine | CX3C1 | CX3CR1 | Human | Cx3Cl1 | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Bradykinin | BKRB1 | B1 | Human | T-Kinin | 4 | Peptide | 5.0 | 5.2 | 5.2 | Refs | ||||
A (Rhodopsin) | Complement peptide | C3AR | C3a | Human | C3a | 2 | Peptide | ||||||||
A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Β-Msh | 2 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide Y | NPY5R | Y5 | Human | Peptide Yy | 6 | Peptide | ||||||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Cck-33 | 5 | Peptide | ||||||||
A (Rhodopsin) | Lysophospholipid (S1P) | S1PR3 | S1P3 | Human | Dihydrosphingosine 1-Phosphate | 2 | Small molecule | ||||||||
A (Rhodopsin) | Neuropeptide Y | NPY2R | Y2 | Human | Pyy-(3-36) | 3 | Peptide | 9.2 | 9.5 | 9.7 | Refs | ||||
A (Rhodopsin) | Cholecystokinin | CCKAR | CCK1 | Human | Cck-4 | 2 | Peptide | ||||||||
A (Rhodopsin) | Neuropeptide Y | NPY5R | Y5 | Human | Pancreatic Polypeptide | 6 | Peptide | ||||||||
A (Rhodopsin) | Class A orphan | LGR6 | LGR6 | Human | R-Spondin-4 | Peptide | Refs | ||||||||
A (Rhodopsin) | Free fatty acid | FFAR4 | FFA4 | Human | Myristic Acid | None | 2 | Small molecule | 5.2 | 5.2 | Refs | ||||
A (Rhodopsin) | Lysophospholipid (LPA) | LPAR5 | LPA5 | Human | Farnesyl Monophosphate | None | 1 | Small molecule | 7.3 | 7.3 | Refs | ||||
B1 (Secretin) | Glucagon receptor family | GLP2R | GLP-2 | Human | Glucagon-Like Peptide 2-(3-33) | 4 | Peptide | ||||||||
F (Frizzled) | Frizzled | FZD1 | FZD1 | Human | Wnt-5a | Peptide | |||||||||
A (Rhodopsin) | Neuropeptide W/neuropeptide B | NPBW1 | NPBW1 | Human | Neuropeptide W-23 | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Proteinase-activated | PAR1 | PAR1 | Human | Thrombin | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Tachykinin | NK3R | NK3 | Human | Substance P | 3 | Peptide | 5.0 | 5.5 | 6.0 | Refs | ||||
A (Rhodopsin) | Opioid | OPRK | κ | Human | Β-Endorphin | 9 | Peptide | ||||||||
A (Rhodopsin) | Prostanoid | PE2R3 | EP3 | Human | Thromboxane A2 | 4 | Small molecule | ||||||||
A (Rhodopsin) | Prostanoid | PD2R2 | DP2 | Human | Pgd3 | None | 3 | Small molecule | |||||||
A (Rhodopsin) | Neuropeptide Y | NPY1R | Y1 | Human | Pancreatic Polypeptide | 4 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR10 | CCR10 | Human | Ccl27 | Peptide | Refs | ||||||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl4 | 8 | Peptide | ||||||||
A (Rhodopsin) | GPR18, GPR55 and GPR119 | GPR55 | GPR55 | Human | Anandamide | None | 3 | Small molecule | 7.7 | 7.7 | Refs | ||||
B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Human | Pthrp | 5 | Peptide | ||||||||
A (Rhodopsin) | Leukotriene | LT4R2 | BLT2 | Human | 12s-Hete | None | 2 | Small molecule | 7.5 | 7.5 | Refs | ||||
A (Rhodopsin) | Melanocortin | MC5R | MC5 | Human | Β-Msh | 2 | Peptide | ||||||||
A (Rhodopsin) | Cholecystokinin | GASR | CCK2 | Human | Gastrin-17 | 5 | Peptide | ||||||||
A (Rhodopsin) | Opioid | OPRM | μ | Human | Dynorphin A | 5 | Peptide | 8.1 | 8.1 | Refs | |||||
A (Rhodopsin) | Chemokine | CCR2 | CCR2 | Human | Ccl7 | 8 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl3 | 8 | Peptide | ||||||||
A (Rhodopsin) | 5-Hydroxytryptamine | 5HT1D | 5-HT1D | Human | 5-Ht-Moduline | None | 2 | Peptide | Refs | ||||||
A (Rhodopsin) | Complement peptide | C5AR1 | C5a1 | Human | C3a | 2 | Peptide | ||||||||
A (Rhodopsin) | Ghrelin | GHSR | ghrelin | Human | [Des-Gln14]Ghrelin | 2 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | ACKR2 | ACKR2 | Human | Ccl22 | Peptide | |||||||||
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Ccl5 | 7 | Peptide | 6.4 | 6.4 | Refs | |||||
A (Rhodopsin) | Chemokine | ACKR1 | ACKR1 | Human | Ccl11 | Peptide | |||||||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl3 | 7 | Peptide | ||||||||
A (Rhodopsin) | Acetylcholine receptors (muscarinic) | ACM5 | M5 | Human | Acetylcholine | Principal | 1 | Small molecule | 6.1 | 6.1 | Refs | ||||
A (Rhodopsin) | Prostanoid | PF2R | FP | Human | Thromboxane A2 | 4 | Small molecule | ||||||||
B1 (Secretin) | VIP and PACAP | VIPR1 | VPAC1 | Human | Ghrh | 4 | Peptide | ||||||||
B1 (Secretin) | Parathyroid hormone | PTH2R | PTH2 | Human | Pth | 5 | Peptide | ||||||||
A (Rhodopsin) | Bradykinin | BKRB2 | B2 | Mouse | [Des-Arg9]Bradykinin | 2 | Peptide | Refs | |||||||
A (Rhodopsin) | Prostanoid | PI2R | IP | Human | Pgd2 | 3 | Small molecule | ||||||||
A (Rhodopsin) | Neuropeptide Y | NPY5R | Y5 | Rat | Pancreatic Polypeptide | 5 | Peptide | 6.5 | 6.5 | Refs | |||||
A (Rhodopsin) | Opioid | OPRK | κ | Human | Dynorphin A | 1 | Peptide | 10.0 | 10.2 | 10.3 | Refs | ||||
A (Rhodopsin) | Melanocortin | MC3R | MC3 | Human | Acth | 3 | Peptide | ||||||||
A (Rhodopsin) | GPR18, GPR55 and GPR119 | GPR55 | GPR55 | Human | N-Palmitoylethanolamine | None | 2 | Small molecule | 8.4 | 8.4 | Refs | ||||
A (Rhodopsin) | Melanocortin | MC4R | MC4 | Mouse | Agouti | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl3 | 3 | Peptide | ||||||||
A (Rhodopsin) | Melanocortin | MC4R | MC4 | Human | Acth | 2 | Peptide | 6.2 | 6.2 | Refs | |||||
B1 (Secretin) | Glucagon receptor family | GLP2R | GLP-2 | Rat | Glucagon-Like Peptide 2 | 1 | Peptide | 10.2 | 10.2 | Refs | |||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | Human | Qrfp43 (43rfa) | 3 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR3 | CCR3 | Human | Ccl2 | 4 | Peptide | 7.2 | 7.5 | 7.8 | Refs | ||||
C (Glutamate) | Class C Orphan | GPC6A | GPRC6 | Human | L-Lysine | None | 3 | Small molecule | 3.8 | 3.8 | Refs | ||||
A (Rhodopsin) | Bradykinin | BKRB2 | B2 | Human | [Hyp3]Bradykinin | 3 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR1 | CCR1 | Human | Ccl7 | 7 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl7 | 8 | Peptide | ||||||||
F (Frizzled) | Frizzled | FZD2 | FZD2 | Human | Wnt-5a | Principal | 1 | Peptide | |||||||
A (Rhodopsin) | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | Human | Neuropeptide Af | 3 | Peptide | ||||||||
A (Rhodopsin) | Chemokine | CXCR3 | CXCR3 | Human | Ccl20 | 5 | Peptide | 6.8 | 6.8 | Refs | |||||
A (Rhodopsin) | Prokineticin | PKR2 | PKR2 | Human | Prokineticin-2Β | 3 | Peptide | Refs | |||||||
B1 (Secretin) | VIP and PACAP | PACR | PAC1 | Human | Phm | 4 | Peptide | ||||||||
B1 (Secretin) | Glucagon receptor family | SCTR | secretin | Human | Secretin | 1 | Peptide | 9.7 | 9.7 | Refs | |||||
A (Rhodopsin) | Somatostatin | SSR5 | SST5 | Mouse | Cortistatin-14 | 4 | Peptide | 8.7 | 9.1 | 9.4 | Refs | ||||
A (Rhodopsin) | Cannabinoid | CNR1 | CB1 | Human | 2-Arachidonoylglycerol | None | 1 | Small molecule | |||||||
A (Rhodopsin) | Chemokine | CXCR2 | CXCR2 | Human | Cxcl5 | 3 | Peptide | ||||||||
A (Rhodopsin) | Melanocortin | MC3R | MC3 | Mouse | Agouti | 3 | Peptide | Refs | |||||||
A (Rhodopsin) | Opioid | OPRK | κ | Human | Dynorphin A-(1-13) | 2 | Peptide | 9.3 | 9.9 | 9.9 | Refs | ||||
A (Rhodopsin) | Chemokine | CCR5 | CCR5 | Human | Ccl11 | 8 | Peptide | Refs | |||||||
A (Rhodopsin) | Peptide P518 | QRFPR | QRFP | Mouse | Qrfp43 | 4 | Peptide | 6.7 | 7.0 | 7.2 | Refs |