Ro64-5229


SMILES Clc1cccc(c1/C(=C/n1cncn1)/OC1CCCCCC1)Cl
InChIKey STCVFKBRXOEQRF-YBEGLDIGSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 351.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.96 6.96 6.96 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Rat Metabotropic glutamate C pIC50 6.3 6.63 6.96 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 6.27 6.27 6.27 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pIC50 7.0 7.0 7.0 Guide to Pharmacology