GPCRdb

PGI₂

PGI₂

SMILES	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@H]2O/C(=C\CCCC(=O)O)C[C@@H]21
InChIKey	KAQKFAOMNZTLHT-OZUDYXHBSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	3
Rotatable bonds	10
Molecular weight (Da)	352.2

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb

No bioactivity data available.

PGI₂

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Endogenous
Approved drug	Yes

Clinical Trials

Phase I 2

Phase II 6

Phase III 0

Approved Yes

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	COVID-19	RA01		0.365	2	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Intracranial injury, unspecified	NA07.Z		0.004	1	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Pulmonary arterial hypertension	BB01.0		0.075	4	Yes
P2Y12	P2Y₁₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Subarachnoid haemorrhage	8B01		0.005	2	Yes
PI2R	IP receptor	Prostanoid receptors	Lipid receptors	Class A	COVID-19	RA01		0.074	2	Yes
PI2R	IP receptor	Prostanoid receptors	Lipid receptors	Class A	Failure or rejection of transplanted organs or tissues	NE84		0.087	2	Yes
PI2R	IP receptor	Prostanoid receptors	Lipid receptors	Class A	Intracranial injury, unspecified	NA07.Z		0.037	1	Yes
PI2R	IP receptor	Prostanoid receptors	Lipid receptors	Class A	Pulmonary arterial hypertension	BB01.0		0.328	4	Yes
PI2R	IP receptor	Prostanoid receptors	Lipid receptors	Class A	Subarachnoid haemorrhage	8B01		0.074	2	Yes

Showing 1 to 9 of 9 entries

This ligand is endogenous.