GPCRdb

L-tryptophan

L-tryptophan

SMILES	N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
InChIKey	QIVBCDIJIAJPQS-VIFPVBQESA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	3
Rotatable bonds	3
Molecular weight (Da)	204.1

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7DD6 7M3E 7M3G 7DTU 7DD5 8SZH 8SZI 8SZI 7DTV 7DD7 8SZG 8SZF 7M3F

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

CaS	CASR	Human	Calcium-sensing	C	pKd	2.60	3.50	4.40	Guide to Pharmacology
CaS	CASR	Human	Calcium-sensing	C	pKd	8.36	8.36	8.36	Drug Central
GPR139	GP139	Human	A orphans	A	pKi	3.13	3.13	3.13	Guide to Pharmacology

Showing 1 to 3 of 3 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

GPR139	GP139	Human	A orphans	A	pIC50	4.59	4.59	4.59	Guide to Pharmacology
GPR139	GP139	Human	A orphans	A	pEC50	3.66	3.66	3.66	Guide to Pharmacology
GPR139	GP139	Human	A orphans	A	pIC50	8.34	8.34	8.34	Drug Central
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.40	4.40	4.40	ChEMBL

Showing 1 to 4 of 4 entries

L-tryptophan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Endogenous
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	7DD6 7M3E 7M3G 7DTU 7DD5 8SZH 8SZI 8SZI 7DTV 7DD7 8SZG 8SZF 7M3F

Compound is not listed as a drug.

This ligand is endogenous.