PDB
7DD7
Resolution
3.2 Å
Released
June 16, 2021
Receptor
CaS
Class
C
Species
Gallus gallus
Ligands
Function
D-tryptophan
Co-agonist
evocalcet
PAM
Calcium
Agonist
Reference
10.1126/SCIADV.ABG1483
D-tryptophan evocalcet Calcium

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Ligand Amino Acid Generic Number Segment Interaction Type
D-tryptophan R66 N-term Van der Waals
D-tryptophan W70 N-term hydrophobic
D-tryptophan W70 N-term aromatic (edge-to-face)
D-tryptophan T145 N-term Van der Waals
D-tryptophan G146 N-term Van der Waals
D-tryptophan S147 N-term polar (hydrogen bond with backbone)
D-tryptophan S147 N-term polar (hydrogen bond)
D-tryptophan A168 N-term polar (hydrogen bond with backbone)
D-tryptophan S170 N-term polar (hydrogen bond with backbone)
D-tryptophan S170 N-term polar (hydrogen bond)
D-tryptophan Y218 N-term aromatic (pi-cation)
Calcium D234 N-term polar (charge-charge)
Calcium D234 N-term metal coordination
D-tryptophan E297 N-term polar (hydrogen bond)
D-tryptophan A298 N-term Van der Waals
D-tryptophan I415 N-term Van der Waals
evocalcet Q680 3.33x33 TM3 Van der Waals
evocalcet F683 3.36x36 TM3 hydrophobic
evocalcet F683 3.36x36 TM3 aromatic (edge-to-face)
evocalcet G684 3.37x37 TM3 Van der Waals
evocalcet F687 3.40x40 TM3 Van der Waals
evocalcet I776 5.44x44 TM5 hydrophobic
evocalcet I821 6.54x54 TM6 Van der Waals
evocalcet Y824 6.57x57 TM6 hydrophobic
evocalcet E836 7.32x33 TM7 hydrophobic
evocalcet E836 7.32x33 TM7 polar (charge-charge)
evocalcet I840 7.36x37 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

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ICL1 T R N P I V K A T ICL1ECL1 G E P ECL1ICL2 E A K I P T S L H R K W W ICL2ECL2 P P S S Y R N H E L E D E I I F I T C H E G S ECL2ICL3 P E N F ICL3ECL3 Y ECL3N-term M T L Y S C C L I L L L F T W N T A A Y G P N Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N N S P N L L P N M T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K I D S L N L D E F C N C S E H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q Q V V E V I Q N S T A R V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P E F F R V I G S T I G F A L K A G Q I P G F R E F L Q K V H P K K S A N N G F A K E F W E E T F N C Y L P S E S K N S P A S A S F H K A H E E G L G A G N G T A A F R P P C T G D E N I T S V E T P Y M D F T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C T P G K G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T S N M G E Q V D F D E F G D L V G N Y S I I N W H L S P E D G S V V F E E V G H Y N V Y A K K G E R L F I N E N K I L W S G F S K E V P F S N C S R D C L P G T R K G I I E G E P T C C F E C V D C P D G E Y S D E T D A S A C D K C P E D Y W S N E N H T S C I P K Q I E F L S W T N-termC-term T A A H A F K V A A R A T L R R S N V S R K R S N S L G G S T G S T P S S S I S S K S N H E D P F P L P A S A E R Q R Q Q Q R G C K Q K V S F G S G T V T L S L S F E E P Q K N A M A N R N A K R R N S L E A Q N S D D S L M R H R A L L A L Q N S E S L S A E P G F Q T A S S P E T S S Q E S V V G D N K E E V P N P E A E P S L P S A N S R N F I G T G G S S V T E N T V H S L E S A L E V L F Q C-term E P F G I A L T L F A V L G I F L T S F V L G V F T K F N R E L S Y L L L F S L L C C F S S S L F F I Q N W T C R L R Q P A F G I S F V L C I S C I L V K T N R V L L V F G L N L Q F L L V F L C T F V Q I V I C V I W L Y T A L M A L G F L I G Y T C L L A A I C F F F A F K S R K L N E A K F I T F S M L I F F I V W I S F I P A Y A S T G K F V S A V E V I A I L A A S F G L L A C I F F N K V Y I I L F K P S R E V R N T I E C S
Helix box plot — Download: PNG | SVG S T L F I G L V A F L T L A I G F P E 1 Y L L L F S L L C C F S S S L F F I 2 V L I C S I C L V F S I G F A P Q R L R 3 Q F L L V F L C T F V Q I V I C V I W L 4 A F F F C I A A L L C T Y G I L F G L A 5 T F S M L I F F I V W I S F I P A Y A S 6 A L L G F S A A L I A I V E V A S V F K 7

GPCRdb(A)
GPCRdb(C)
CaS receptor
TM3
3x29 3.33x33 Q680
3x32 3.36x36 F683
3x33 3.37x37 G684
3x36 3.40x40 F687
TM5
5x44 5.44x44 I776
TM6
6x52 6.54x54 I821
6x55 6.57x57 Y824
TM7
7x38 7.32x33 E836
7x42 7.36x37 I840