PDB
7DD5
Resolution
3.2 Å
Released
June 16, 2021
Receptor
CaS
Class
C
Species
Gallus gallus
Ligands
Function
NPS 2143
NAM
D-tryptophan
Co-agonist
Calcium
Agonist
Reference
10.1126/SCIADV.ABG1483
NPS 2143 D-tryptophan Calcium

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Ligand Amino Acid Generic Number Segment Interaction Type
D-tryptophan R66 N-term Van der Waals
D-tryptophan W70 N-term aromatic (edge-to-face)
D-tryptophan T145 N-term Van der Waals
D-tryptophan G146 N-term Van der Waals
D-tryptophan S147 N-term polar (hydrogen bond)
D-tryptophan A168 N-term polar (hydrogen bond with backbone)
D-tryptophan A168 N-term hydrophobic
D-tryptophan S170 N-term Van der Waals
D-tryptophan Y218 N-term Van der Waals
Calcium D234 N-term polar (charge-charge)
D-tryptophan E297 N-term Van der Waals
D-tryptophan A298 N-term Van der Waals
D-tryptophan I415 N-term Van der Waals
NPS 2143 Q680 3.33x33 TM3 Van der Waals
NPS 2143 F683 3.36x36 TM3 hydrophobic
NPS 2143 L772 5.40x40 TM5 hydrophobic
NPS 2143 I776 5.44x44 TM5 hydrophobic
NPS 2143 V816 6.49x49 TM6 Van der Waals
NPS 2143 W817 6.50x50 TM6 Van der Waals
NPS 2143 F820 6.53x53 TM6 Van der Waals
NPS 2143 I821 6.54x54 TM6 Van der Waals
NPS 2143 Y824 6.57x57 TM6 aromatic (pi-cation)
NPS 2143 Y824 6.57x57 TM6 hydrophobic
NPS 2143 E836 7.32x33 TM7 polar (hydrogen bond)
NPS 2143 E836 7.32x33 TM7 polar (charge-charge)
NPS 2143 I840 7.36x37 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

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ICL1 T R N P I V K A T ICL1ECL1 G E P ECL1ICL2 E A K I P T S L H R K W W ICL2ECL2 P P S S Y R N H E L E D E I I F I T C H E G S ECL2ICL3 P E N F ICL3ECL3 Y ECL3N-term M T L Y S C C L I L L L F T W N T A A Y G P N Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N N S P N L L P N M T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K I D S L N L D E F C N C S E H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q Q V V E V I Q N S T A R V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P E F F R V I G S T I G F A L K A G Q I P G F R E F L Q K V H P K K S A N N G F A K E F W E E T F N C Y L P S E S K N S P A S A S F H K A H E E G L G A G N G T A A F R P P C T G D E N I T S V E T P Y M D F T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C T P G K G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T S N M G E Q V D F D E F G D L V G N Y S I I N W H L S P E D G S V V F E E V G H Y N V Y A K K G E R L F I N E N K I L W S G F S K E V P F S N C S R D C L P G T R K G I I E G E P T C C F E C V D C P D G E Y S D E T D A S A C D K C P E D Y W S N E N H T S C I P K Q I E F L S W T N-termC-term T A A H A F K V A A R A T L R R S N V S R K R S N S L G G S T G S T P S S S I S S K S N H E D P F P L P A S A E R Q R Q Q Q R G C K Q K V S F G S G T V T L S L S F E E P Q K N A M A N R N A K R R N S L E A Q N S D D S L M R H R A L L A L Q N S E S L S A E P G F Q T A S S P E T S S Q E S V V G D N K E E V P N P E A E P S L P S A N S R N F I G T G G S S V T E N T V H S L E S A L E V L F Q C-term E P F G I A L T L F A V L G I F L T S F V L G V F T K F N R E L S Y L L L F S L L C C F S S S L F F I Q N W T C R L R Q P A F G I S F V L C I S C I L V K T N R V L L V F G L N L Q F L L V F L C T F V Q I V I C V I W L Y T A L M A L G F L I G Y T C L L A A I C F F F A F K S R K L N E A K F I T F S M L I F F I V W I S F I P A Y A S T G K F V S A V E V I A I L A A S F G L L A C I F F N K V Y I I L F K P S R E V R N T I E C S
Helix box plot — Download: PNG | SVG S T L F I G L V A F L T L A I G F P E 1 Y L L L F S L L C C F S S S L F F I 2 V L I C S I C L V F S I G F A P Q R L R 3 Q F L L V F L C T F V Q I V I C V I W L 4 A F F F C I A A L L C T Y G I L F G L A 5 T F S M L I F F I V W I S F I P A Y A S 6 A L L G F S A A L I A I V E V A S V F K 7

GPCRdb(A)
GPCRdb(C)
CaS receptor
TM3
3x29 3.33x33 Q680
3x32 3.36x36 F683
TM5
5x40 5.40x40 L772
5x44 5.44x44 I776
TM6
6x47 6.49x49 V816
6x48 6.50x50 W817
6x51 6.53x53 F820
6x52 6.54x54 I821
6x55 6.57x57 Y824
TM7
7x38 7.32x33 E836
7x42 7.36x37 I840