NPS 2143 [5862]



NPS 2143


SMILES CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N
InChIKey PZUJQWHTIRWCID-HXUWFJFHSA-N

Chemical Properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 8
Log P 4.715
Molecular weight (Da) 408.2
Stereochemistry info full

Database connections

Structure pdb 7DD5 7SIN 7M3E 7M3J
Ligand site mutations CaS GPRC6
GPCRdb related ligands

Bioactivities

Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database
Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database

NPS 2143


Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Distribution across phases (no. indications)

Phase I 0
Phase II 0
Phase III 0
Phase IV 0

Database connections

Structure pdb 7DD5 7SIN 7M3E 7M3J
Ligand site mutations CaS GPRC6

Compound is not listed as a drug.