MC2 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8GY7

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41422-022-00751-6

PUBLICATION DATE

Jan. 11, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

80 interactions (Click to see)

LIGANDS

ACTH - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem

PHYSIOLOGICAL LIGANDS

ACTH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic TM3 R 128 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 128 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 128 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 I 132 3x54 G.H5 H 354 G.H5.19
Van-der-waals TM3 I 132 3x54 G.H5 H 354 G.H5.19
Polar TM4 T 143 4x38 G.HN Q 28 G.HN.45
Van-der-waals TM4 T 143 4x38 G.HN Q 28 G.HN.45
Ionic ICL4 R 279 - G.H5 E 359 G.H5.24
Polar ICL4 R 279 - G.H5 E 359 G.H5.24
Hydrophobic ICL4 R 279 - G.H5 E 359 G.H5.24
Van-der-waals ICL4 R 279 - G.H5 E 359 G.H5.24
Hydrophobic TM6 K 216 6x32 G.H5 L 361 G.H5.26
Van-der-waals TM6 K 216 6x32 G.H5 L 361 G.H5.26
Hydrophobic ICL2 A 135 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 A 135 - G.H5 I 350 G.H5.15
Polar ICL2 R 137 - H.hehf K 193 H.hehf.07
Hydrophobic TM5 M 196 5x61 G.H5 L 355 G.H5.20
Polar TM5 H 203 5x68 G.H5 R 352 G.H5.17
Van-der-waals TM5 H 203 5x68 G.H5 R 352 G.H5.17
Polar ICL2 H 139 - G.HN R 31 G.HN.48
Aromatic ICL2 H 139 - G.HN R 31 G.HN.48
Hydrophobic ICL2 H 139 - G.HN R 31 G.HN.48
Polar TM5 H 203 5x68 G.H5 Q 351 G.H5.16
Hydrophobic TM5 H 203 5x68 G.H5 Q 351 G.H5.16
Van-der-waals TM5 H 203 5x68 G.H5 Q 351 G.H5.16
Hydrophobic TM3 T 131 3x53 G.H5 H 354 G.H5.19
Hydrophobic TM5 H 203 5x68 G.H5 L 361 G.H5.26
Van-der-waals TM5 H 203 5x68 G.H5 L 361 G.H5.26
Hydrophobic TM5 L 199 5x64 G.H5 L 355 G.H5.20
Van-der-waals TM5 L 199 5x64 G.H5 L 355 G.H5.20
Polar TM6 G 217 6x33 G.H5 E 359 G.H5.24
Hydrophobic TM6 G 217 6x33 G.H5 E 359 G.H5.24
Van-der-waals TM6 G 217 6x33 G.H5 E 359 G.H5.24
Hydrophobic TM6 T 220 6x36 G.H5 L 360 G.H5.25
Hydrophobic TM5 A 200 5x65 G.H5 L 355 G.H5.20
Polar ICL2 L 136 - G.HN H 34 G.HN.51
Hydrophobic ICL2 L 136 - G.HN H 34 G.HN.51
Van-der-waals ICL2 L 136 - G.HN H 34 G.HN.51
Polar TM2 Y 60 2x40 G.H5 Q 357 G.H5.22
Van-der-waals ICL2 H 139 - G.HN Q 28 G.HN.45
Ionic TM5 H 203 5x68 G.H5 D 348 G.H5.13
Polar TM5 H 203 5x68 G.H5 D 348 G.H5.13
Hydrophobic TM5 H 203 5x68 G.H5 D 348 G.H5.13
Van-der-waals TM5 H 203 5x68 G.H5 D 348 G.H5.13
Polar TM3 I 132 3x54 G.H5 Q 351 G.H5.16
Hydrophobic TM3 I 132 3x54 G.H5 Q 351 G.H5.16
Van-der-waals TM3 I 132 3x54 G.H5 Q 351 G.H5.16
Hydrophobic TM3 I 132 3x54 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 L 136 - G.H5 R 347 G.H5.12
Hydrophobic ICL2 L 136 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 L 136 - G.H5 F 343 G.H5.08
Hydrophobic ICL2 A 135 - G.H5 Q 351 G.H5.16
Hydrophobic ICL2 L 136 - G.S3 F 196 G.S3.03
Hydrophobic TM5 F 197 5x62 G.H5 L 360 G.H5.25
Hydrophobic TM6 G 217 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 G 217 6x33 G.H5 L 360 G.H5.25
Hydrophobic ICL2 L 136 - H.HF V 194 H.HF.01
Polar ICL3 N 214 - G.H5 L 360 G.H5.25
Van-der-waals ICL3 N 214 - G.H5 L 360 G.H5.25
Hydrophobic TM3 I 132 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 I 132 3x54 G.H5 L 355 G.H5.20
Polar TM6 T 220 6x36 G.H5 E 359 G.H5.24
Hydrophobic TM6 T 220 6x36 G.H5 E 359 G.H5.24
Van-der-waals TM6 T 220 6x36 G.H5 E 359 G.H5.24
Hydrophobic ICL2 L 136 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 L 136 - G.H5 I 350 G.H5.15
Hydrophobic TM2 M 59 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 M 59 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM5 A 200 5x65 G.H5 L 360 G.H5.25
Van-der-waals TM5 A 200 5x65 G.H5 L 360 G.H5.25
Hydrophobic TM5 I 207 5x72 G.h4s6 Y 325 G.h4s6.20
Van-der-waals TM5 I 207 5x72 G.h4s6 Y 325 G.h4s6.20
Polar TM3 T 131 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 T 131 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM6 T 220 6x36 G.H5 Y 358 G.H5.23
Hydrophobic TM6 L 221 6x37 G.H5 L 360 G.H5.25
Ionic ICL2 R 137 - H.hehf D 192 H.hehf.06
Polar ICL2 R 137 - H.hehf D 192 H.hehf.06
Van-der-waals ICL2 R 137 - H.hehf D 192 H.hehf.06
Hydrophobic ICL2 L 136 - G.H5 C 346 G.H5.11
Van-der-waals ICL2 L 136 - G.H5 C 346 G.H5.11
Hydrophobic TM5 M 196 5x61 G.H5 Y 358 G.H5.23
Van-der-waals TM5 M 196 5x61 G.H5 Y 358 G.H5.23
Hydrophobic TM5 I 207 5x72 G.H5 L 361 G.H5.26
Hydrophobic TM5 A 200 5x65 G.H5 L 361 G.H5.26
Hydrophobic TM6 K 216 6x32 G.H5 E 359 G.H5.24
Van-der-waals TM6 K 216 6x32 G.H5 E 359 G.H5.24
Hydrophobic TM5 L 199 5x64 G.H5 Q 351 G.H5.16
Van-der-waals TM5 L 199 5x64 G.H5 Q 351 G.H5.16
Hydrophobic TM5 M 196 5x61 G.H5 L 360 G.H5.25
Van-der-waals TM5 M 196 5x61 G.H5 L 360 G.H5.25
Hydrophobic TM5 I 207 5x72 G.H5 R 352 G.H5.17
Van-der-waals TM5 I 207 5x72 G.H5 R 352 G.H5.17