PDB
8GY7
Resolution
3.3 Å
Released
Jan. 11, 2023
Receptor
MC2
Class
A
Species
Homo sapiens
Ligands
ACTH (Corticotropin)
Calcium
Function
Agonist
Cofactor
Reference
10.1038/S41422-022-00751-6
ACTH (Corticotropin) Calcium

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Ligand Amino Acid Generic Number Segment Interaction Type
ACTH (Corticotropin) R23 N-term Van der Waals
ACTH (Corticotropin) E28 1.36x36 TM1 polar (charge-assisted hydrogen bond)
ACTH (Corticotropin) F31 1.39x39 TM1 Van der Waals
ACTH (Corticotropin) F31 1.39x39 TM1 hydrophobic
ACTH (Corticotropin) Y76 2.56x56 TM2 Van der Waals
ACTH (Corticotropin) Y76 2.56x56 TM2 polar (hydrogen bond)
ACTH (Corticotropin) E80 2.60x60 TM2 polar (charge-assisted hydrogen bond)
Calcium E80 2.60x60 TM2 Van der Waals
ACTH (Corticotropin) N81 2.61x61 TM2 Van der Waals
ACTH (Corticotropin) L83 2.63x63 TM2 hydrophobic
ACTH (Corticotropin) I84 2.64x64 TM2 Van der Waals
ACTH (Corticotropin) I84 2.64x64 TM2 hydrophobic
ACTH (Corticotropin) R87 2.67x67 TM2 polar (charge-assisted hydrogen bond)
ACTH (Corticotropin) R95 ECL1 polar (charge-assisted hydrogen bond)
ACTH (Corticotropin) E99 3.21x21 TM3 polar (charge-assisted hydrogen bond)
ACTH (Corticotropin) A102 3.24x24 TM3 hydrophobic
ACTH (Corticotropin) A102 3.24x24 TM3 Van der Waals
ACTH (Corticotropin) D103 3.25x25 TM3 polar (hydrogen bond with backbone)
Calcium D103 3.25x25 TM3 polar (charge-charge)
ACTH (Corticotropin) D103 3.25x25 TM3 polar (charge-assisted hydrogen bond)
ACTH (Corticotropin) D104 3.26x26 TM3 Van der Waals
Calcium D107 3.29x29 TM3 polar (charge-charge)
ACTH (Corticotropin) D107 3.29x29 TM3 polar (charge-assisted hydrogen bond)
ACTH (Corticotropin) F110 3.32x32 TM3 Van der Waals
ACTH (Corticotropin) F110 3.32x32 TM3 aromatic (face-to-edge)
ACTH (Corticotropin) V111 3.33x33 TM3 hydrophobic
ACTH (Corticotropin) V111 3.33x33 TM3 Van der Waals
ACTH (Corticotropin) V166 4.61x61 TM4 Van der Waals
ACTH (Corticotropin) S169 ECL2 polar (hydrogen bond)
ACTH (Corticotropin) H170 ECL2 Van der Waals
ACTH (Corticotropin) F178 5.43x43 TM5 Van der Waals
ACTH (Corticotropin) F178 5.43x43 TM5 aromatic (face-to-face)
ACTH (Corticotropin) F235 6.51x51 TM6 Van der Waals
ACTH (Corticotropin) F235 6.51x51 TM6 hydrophobic
ACTH (Corticotropin) H238 6.54x54 TM6 polar (hydrogen bond)
ACTH (Corticotropin) H238 6.54x54 TM6 Van der Waals
ACTH (Corticotropin) V239 6.55x55 TM6 Van der Waals
ACTH (Corticotropin) V239 6.55x55 TM6 hydrophobic
ACTH (Corticotropin) M242 6.58x58 TM6 polar (hydrogen bond)
ACTH (Corticotropin) P246 ECL3 hydrophobic
ACTH (Corticotropin) P246 ECL3 Van der Waals
ACTH (Corticotropin) F258 7.35x34 TM7 Van der Waals
ACTH (Corticotropin) F258 7.35x34 TM7 hydrophobic
ACTH (Corticotropin) Q259 7.36x35 TM7 Van der Waals
ACTH (Corticotropin) Q259 7.36x35 TM7 polar (hydrogen bond)
ACTH (Corticotropin) G262 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K N L Q ICL1ECL1 Y L K P R ECL1ICL2 A L R Y H S I V ICL2ECL2 H ECL2ICL3 T L P R A ICL3ECL3 P S ECL3N-term M K H I I N S Y E N I N N T A R N N S D C P R V V L N-termC-term R Y W C-term P E E I F F T I S I V G V L E N L I V L L A V F K N A P M Y F F I C S L A I S D M L G S L Y K I L E N I L I I L R N M G G S F E T T A D D I I D S L F V L S L L G S I F S L S V I A A D R Y I T I F H T M R R T V V V L T V I W T F C T G T G I T M V I F S H V P T V I T F T S L F P L M L V F I L C L Y V H M F L L A R S H T R K I S N M K G A I T L T I L L G V F I F C W A P F V L H V L L M T F C N P Y C A C Y M S L F Q V N G M L I M C N A V I D P F I Y A F R S P E F K K S L R D A M I F C
Helix box plot — Download: PNG | SVG L N E L V G V I S I T F F I E E P 1 C S L A I S D M L G S L Y K I L E N I L 2 V S L S F I S G L L S L V F L S D I I D 3 T V V V L T V I W T F C T G T G I T M V 4 Y L C L I F V L M L P F L S T F T I V T 5 T I L L G V F I F C W A P F V L H V L L 6 F P D I V A N C M I L M G N V Q F L S 7

GPCRdb(A)
GPCRdb(A)
MC2 receptor
TM1
1x36 1.36x36 E28
1x39 1.39x39 F31
TM2
2x56 2.56x56 Y76
2x60 2.60x60 E80
2x61 2.61x61 N81
2x63 2.63x63 L83
2x64 2.64x64 I84
2x67 2.67x67 R87
TM3
3x21 3.21x21 E99
3x24 3.24x24 A102
3x25 3.25x25 D103
3x26 3.26x26 D104
3x29 3.29x29 D107
3x32 3.32x32 F110
3x33 3.33x33 V111
TM4
4x61 4.61x61 V166
TM5
5x43 5.43x43 F178
TM6
6x51 6.51x51 F235
6x54 6.54x54 H238
6x55 6.55x55 V239
6x58 6.58x58 M242
TM7
7x34 7.35x34 F258
7x35 7.36x35 Q259
7x38 7.39x38 G262