Structure information

MC2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8GY7

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-022-00751-6

PUBLICATION DATE

Jan. 11, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ACTH R23 N-term Van der Waals
ACTH E28 1.36x36 TM1 polar (charge-assisted hydrogen bond)
ACTH F31 1.39x39 TM1 Van der Waals
ACTH F31 1.39x39 TM1 hydrophobic
ACTH Y76 2.56x56 TM2 polar (hydrogen bond)
ACTH Y76 2.56x56 TM2 Van der Waals
ACTH E80 2.60x60 TM2 polar (charge-assisted hydrogen bond)
ACTH N81 2.61x61 TM2 Van der Waals
ACTH L83 2.63x63 TM2 hydrophobic
ACTH I84 2.64x64 TM2 hydrophobic
ACTH I84 2.64x64 TM2 Van der Waals
ACTH R87 2.67x67 TM2 polar (charge-assisted hydrogen bond)
ACTH R95 ECL1 polar (charge-assisted hydrogen bond)
ACTH E99 3.21x21 TM3 polar (charge-assisted hydrogen bond)
ACTH A102 3.24x24 TM3 Van der Waals
ACTH A102 3.24x24 TM3 hydrophobic
ACTH D103 3.25x25 TM3 polar (charge-assisted hydrogen bond)
ACTH D103 3.25x25 TM3 polar (hydrogen bond with backbone)
ACTH D104 3.26x26 TM3 Van der Waals
ACTH D107 3.29x29 TM3 polar (charge-assisted hydrogen bond)
ACTH F110 3.32x32 TM3 Van der Waals
ACTH F110 3.32x32 TM3 aromatic (face-to-edge)
ACTH V111 3.33x33 TM3 hydrophobic
ACTH V111 3.33x33 TM3 Van der Waals
ACTH V166 4.61x61 TM4 Van der Waals
ACTH S169 ECL2 polar (hydrogen bond)
ACTH H170 ECL2 Van der Waals
ACTH F178 5.43x43 TM5 aromatic (face-to-face)
ACTH F178 5.43x43 TM5 Van der Waals
ACTH F235 6.51x51 TM6 hydrophobic
ACTH F235 6.51x51 TM6 Van der Waals
ACTH H238 6.54x54 TM6 Van der Waals
ACTH H238 6.54x54 TM6 polar (hydrogen bond)
ACTH V239 6.55x55 TM6 hydrophobic
ACTH V239 6.55x55 TM6 Van der Waals
ACTH M242 6.58x58 TM6 polar (hydrogen bond)
ACTH P246 ECL3 hydrophobic
ACTH P246 ECL3 Van der Waals
ACTH F258 7.35x34 TM7 hydrophobic
ACTH F258 7.35x34 TM7 Van der Waals
ACTH Q259 7.36x35 TM7 polar (hydrogen bond)
ACTH Q259 7.36x35 TM7 Van der Waals
ACTH G262 7.39x38 TM7 Van der Waals

Ligands

ACTH

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Residue Diagrams

L N E L V G V I S I T F F I E E P 1 C S L A I S D M L G S L Y K I L E N I L 2 V S L S F I S G L L S L V F L S D I I D 3 T V V V L T V I W T F C T G T G I T M V 4 Y L C L I F V L M L P F L S T F T I V T 5 T I L L G V F I F C W A P F V L H V L L 6 F P D I V A N C M I L M G N V Q F L S 7
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ICL1 K N L Q ICL1ECL1 Y L K P R ECL1ICL2 A L R Y H S I V ICL2ECL2 H ECL2ICL3 T L P R A ICL3ECL3 P S ECL3N-term M K H I I N S Y E N I N N T A R N N S D C P R V V L N-termC-term R Y W C-term P E E I F F T I S I V G V L E N L I V L L A V F K N A P M Y F F I C S L A I S D M L G S L Y K I L E N I L I I L R N M G G S F E T T A D D I I D S L F V L S L L G S I F S L S V I A A D R Y I T I F H T M R R T V V V L T V I W T F C T G T G I T M V I F S H V P T V I T F T S L F P L M L V F I L C L Y V H M F L L A R S H T R K I S N M K G A I T L T I L L G V F I F C W A P F V L H V L L M T F C N P Y C A C Y M S L F Q V N G M L I M C N A V I D P F I Y A F R S P E F K K S L R D A M I F C
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC2 receptor
TM1
1x36 1.36x36 E28
1x39 1.39x39 F31
TM2
2x56 2.56x56 Y76
2x60 2.60x60 E80
2x61 2.61x61 N81
2x63 2.63x63 L83
2x64 2.64x64 I84
2x67 2.67x67 R87
TM3
3x21 3.21x21 E99
3x24 3.24x24 A102
3x25 3.25x25 D103
3x26 3.26x26 D104
3x29 3.29x29 D107
3x32 3.32x32 F110
3x33 3.33x33 V111
TM4
4x61 4.61x61 V166
TM5
5x43 5.43x43 F178
TM6
6x51 6.51x51 F235
6x54 6.54x54 H238
6x55 6.55x55 V239
6x58 6.58x58 M242
TM7
7x34 7.35x34 F258
7x35 7.36x35 Q259
7x38 7.39x38 G262