MC2 receptor (acthr_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor
GENE
MC2R (ACTHR)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Adrenocorticotropic hormone receptor, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
K
|
H
|
I
|
I
|
N
|
S
|
Y
|
E
|
N
|
10 |
I
|
N
|
N
|
T
|
A
|
R
|
N
|
N
|
S
|
D
|
20 |
TM1 | |||||||||
C
|
P
|
R
|
V
|
V
|
L
|
P
|
E
|
E
|
I
|
30 |
F
|
F
|
T
|
I
|
S
|
I
|
V
|
G
|
V
|
L
|
40 |
E
|
N
|
L
|
I
|
V
|
L
|
L
|
A
|
V
|
F
|
50 |
ICL1 | TM2 | ||||||||
K
|
N
|
K
|
N
|
L
|
Q
|
A
|
P
|
M
|
Y
|
60 |
F
|
F
|
I
|
C
|
S
|
L
|
A
|
I
|
S
|
D
|
70 |
M
|
L
|
G
|
S
|
L
|
Y
|
K
|
I
|
L
|
E
|
80 |
N
|
I
|
L
|
I
|
I
|
L
|
R
|
N
|
M
|
G
|
90 |
ECL1 | TM3 | ||||||||
Y
|
L
|
K
|
P
|
R
|
G
|
S
|
F
|
E
|
T
|
100 |
T
|
A
|
D
|
D
|
I
|
I
|
D
|
S
|
L
|
F
|
110 |
V
|
L
|
S
|
L
|
L
|
G
|
S
|
I
|
F
|
S
|
120 |
L
|
S
|
V
|
I
|
A
|
A
|
D
|
R
|
Y
|
I
|
130 |
ICL2 | |||||||||
T
|
I
|
F
|
H
|
A
|
L
|
R
|
Y
|
H
|
S
|
140 |
TM4 | |||||||||
I
|
V
|
T
|
M
|
R
|
R
|
T
|
V
|
V
|
V
|
150 |
L
|
T
|
V
|
I
|
W
|
T
|
F
|
C
|
T
|
G
|
160 |
T
|
G
|
I
|
T
|
M
|
V
|
I
|
F
|
S
|
H
|
170 |
TM5 | |||||||||
H
|
V
|
P
|
T
|
V
|
I
|
T
|
F
|
T
|
S
|
180 |
L
|
F
|
P
|
L
|
M
|
L
|
V
|
F
|
I
|
L
|
190 |
C
|
L
|
Y
|
V
|
H
|
M
|
F
|
L
|
L
|
A
|
200 |
R
|
S
|
H
|
T
|
R
|
K
|
I
|
S
|
T
|
L
|
210 |
ICL3 | TM6 | ||||||||
P
|
R
|
A
|
N
|
M
|
K
|
G
|
A
|
I
|
T
|
220 |
L
|
T
|
I
|
L
|
L
|
G
|
V
|
F
|
I
|
F
|
230 |
C
|
W
|
A
|
P
|
F
|
V
|
L
|
H
|
V
|
L
|
240 |
ECL3 | TM7 | ||||||||||
L
|
M
|
T
|
F
|
C
|
P
|
S
|
N
|
P
|
Y
|
||
250 |
C
|
A
|
C
|
Y
|
M
|
S
|
L
|
F
|
Q
|
V
|
260 |
N
|
G
|
M
|
L
|
I
|
M
|
C
|
N
|
A
|
V
|
270 |
I
|
D
|
P
|
F
|
I
|
Y
|
A
|
F
|
R
|
S
|
280 |
H8 | |||||||||
P
|
E
|
L
|
R
|
D
|
A
|
F
|
K
|
K
|
M
|
290 |
C-term | |||||||||
I
|
F
|
C
|
S
|
R
|
Y
|
W
|
|||
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
ENDOGENOUS LIGANDS
ACTH
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 8GY7