CCR5 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7F1Q

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

July 14, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

89 interactions (Click to see)

LIGANDS

CCL3 - Agonist gtoplig

PHYSIOLOGICAL LIGANDS

CCL11, CCL14, CCL2, CCL8, CCL5, CCL16, CCL4, CCL13, CCL7, CCL3



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 313 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 332 6x36 G.H5 G 352 G.H5.24
Polar TM3 R 222 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 222 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 222 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 317 5x65 G.H5 F 354 G.H5.26
Van-der-waals TM5 L 317 5x65 G.H5 F 354 G.H5.26
Polar TM6 R 328 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 328 6x32 G.H5 L 353 G.H5.25
Polar TM6 N 322 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 L 233 34x54 G.S1 V 34 G.S1.02
Hydrophobic ICL2 A 229 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 229 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 233 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 233 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 230 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 R 319 5x67 G.H5 T 340 G.H5.12
Hydrophobic TM6 I 333 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 333 6x37 G.H5 L 353 G.H5.25
Polar TM6 R 328 6x32 G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 233 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 233 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 233 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 233 34x54 G.S3 L 194 G.S3.01
Hydrophobic TM5 L 317 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 225 3x53 G.H5 I 344 G.H5.16
Van-der-waals TM3 A 225 3x53 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 222 3x50 G.H5 L 353 G.H5.25
Ionic TM5 R 319 5x67 G.H5 D 341 G.H5.13
Polar TM5 R 319 5x67 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 319 5x67 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 319 5x67 G.H5 D 341 G.H5.13
Hydrophobic H8 G 397 8x47 G.H5 G 352 G.H5.24
Polar ICL2 R 236 34x57 G.H5 N 347 G.H5.19
Hydrophobic TM6 K 325 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 325 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 C 320 5x68 G.H5 F 354 G.H5.26
Van-der-waals TM5 C 320 5x68 G.H5 F 354 G.H5.26
Hydrophobic TM5 C 320 5x68 G.H5 K 345 G.H5.17
Van-der-waals TM5 C 320 5x68 G.H5 K 345 G.H5.17
Hydrophobic ICL2 K 234 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 234 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 V 226 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 226 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 332 6x36 G.H5 L 353 G.H5.25
Polar TM3 A 225 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 225 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 225 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 230 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 230 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM2 T 161 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 229 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 229 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 226 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 226 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 329 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 329 6x33 G.H5 F 354 G.H5.26