ghrelin receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7F9Y

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41467-021-25364-2

PUBLICATION DATE

Aug. 18, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

65 interactions (Click to see)

LIGANDS

ghrelin - Agonist gtoplig

ENDOGENOUS LIGANDS

[des-Gln14]ghrelin, ghrelin



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 141 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 265 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 149 34x51 G.S1 L 41 G.S1.02
Hydrophobic ICL2 P 148 34x50 G.H5 I 383 G.H5.15
Polar TM3 R 141 3x50 G.H5 N 392 G.H5.24
Hydrophobic ICL2 L 149 34x51 G.H5 C 379 G.H5.11
Ionic H8 K 329 8x49 G.H5 E 390 G.H5.22
Polar H8 K 329 8x49 G.H5 E 390 G.H5.22
Van-der-waals H8 K 329 8x49 G.H5 E 390 G.H5.22
Hydrophobic TM3 I 145 3x54 G.H5 N 387 G.H5.19
Polar TM3 A 144 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 N 387 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 387 G.H5.19
Hydrophobic ICL2 L 149 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 149 34x51 G.H5 F 376 G.H5.08
Polar TM3 R 141 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 149 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM6 T 261 6x33 G.H5 V 394 G.H5.26
Polar TM6 T 261 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 261 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 261 6x33 G.H5 L 393 G.H5.25
Polar TM7 Y 323 7x53 G.H5 N 392 G.H5.24
Van-der-waals TM7 Y 323 7x53 G.H5 N 392 G.H5.24
Hydrophobic ICL2 R 150 34x52 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 R 150 34x52 G.s2s3 K 216 G.s2s3.02
Polar TM3 E 140 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 140 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM2 L 82 2x43 G.H5 N 392 G.H5.24
Van-der-waals TM2 L 82 2x43 G.H5 N 392 G.H5.24
Hydrophobic ICL2 P 148 34x50 G.H5 K 380 G.H5.12
Polar TM6 H 258 6x30 G.H5 Q 385 G.H5.17
Hydrophobic TM5 L 239 5x65 G.H5 L 384 G.H5.16
Hydrophobic TM3 I 145 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 145 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM2 T 78 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 78 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 149 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 149 34x51 G.H5 K 380 G.H5.12
Polar H8 S 327 8x47 G.H5 N 392 G.H5.24
Hydrophobic H8 S 327 8x47 G.H5 N 392 G.H5.24
Van-der-waals H8 S 327 8x47 G.H5 N 392 G.H5.24
Polar TM2 T 78 2x39 G.H5 E 390 G.H5.22
Hydrophobic TM3 I 145 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 145 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 239 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM7 M 326 7x56 G.H5 V 394 G.H5.26
Van-der-waals TM7 M 326 7x56 G.H5 V 394 G.H5.26
Polar TM2 T 77 2x38 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 148 34x50 G.H5 L 384 G.H5.16
Van-der-waals ICL2 P 148 34x50 G.H5 L 384 G.H5.16
Hydrophobic TM3 I 145 3x54 G.H5 L 384 G.H5.16
Van-der-waals TM3 I 145 3x54 G.H5 L 384 G.H5.16
Hydrophobic TM3 A 144 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 144 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM6 H 258 6x30 G.H5 L 388 G.H5.20
Hydrophobic ICL2 V 153 34x55 G.hns1 R 39 G.hns1.03
Van-der-waals ICL2 V 153 34x55 G.hns1 R 39 G.hns1.03