GPCRdb

histamine

histamine

SMILES	NCCc1cnc[nH]1
InChIKey	NTYJJOPFIAHURM-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	2
Rotatable bonds	2
Molecular weight (Da)	111.1

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	8JXT 8POK 7DFL 7YFC 8HN8 8YUU 8YN2 8YN3 8YN4 8YN5 8YN9
Ligand site mutations	H₁ H₃ H₄

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	F6Q2H9	Bovine	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.22	5.22	5.22	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.67	6.00	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₂	DRD2	Rat	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	4.70	5.30	5.90	Guide to Pharmacology
H₁	HRH1	Rat	Histamine	A	pKd	8.00	8.00	8.00	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pKd	8.00	8.91	9.11	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pKi	4.90	4.90	4.90	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	4.10	4.80	5.62	ChEMBL
H₁	HRH1	Human	Histamine	A	pKd	8.35	8.35	8.35	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	4.20	5.51	7.80	PDSP Ki database
H₁	HRH1	Guinea pig	Histamine	A	pKi	4.57	5.30	7.00	PDSP Ki database
H₁	HRH1	Rat	Histamine	A	pKi	4.40	4.70	5.00	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	8.39	8.39	8.39	Drug Central
H₂	HRH2	Rat	Histamine	A	pKi	3.80	3.80	3.80	Guide to Pharmacology

Showing 1 to 20 of 63 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₁	HRH1	Rat	Histamine	A	pEC50	5.35	5.35	5.35	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pEC50	6.70	6.73	6.79	ChEMBL
H₁	HRH1	Human	Histamine	A	pEC50	6.70	6.92	7.89	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	6.80	6.80	6.80	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pEC50	8.17	8.17	8.17	Drug Central
H₁	HRH1	Rat	Histamine	A	pEC50	8.27	8.27	8.27	Drug Central
H₂	HRH2	Human	Histamine	A	pEC50	5.26	5.94	6.94	ChEMBL
H₂	HRH2	Guinea pig	Histamine	A	pEC50	8.22	8.22	8.22	Drug Central
H₃	HRH3	Rat	Histamine	A	pEC50	7.21	7.21	7.21	ChEMBL
H₃	HRH3	Human	Histamine	A	pEC50	6.19	7.77	8.60	ChEMBL
H₄	HRH4	Mouse	Histamine	A	pEC50	5.17	6.13	7.06	ChEMBL
H₄	HRH4	Rat	Histamine	A	pEC50	4.28	5.76	6.80	ChEMBL
H₄	HRH4	Human	Histamine	A	pEC50	5.75	7.66	8.13	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.50	4.50	4.50	ChEMBL

Showing 1 to 14 of 14 entries

histamine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Endogenous
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 3

Phase III 9

Approved Yes

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	8JXT 8POK 7DFL 7YFC 8HN8 8YUU 8YN2 8YN3 8YN4 8YN5 8YN9
Ligand site mutations	H₁ H₃ H₄

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Leukaemia, unspecified	2B33.4	V04C, L03A	0.259	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Malignant neoplasms of kidney, except renal pelvis, unspecified	2C90.Z	V04C, L03A	0.101	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Melanoma of skin, unspecified	2C30.Z	V04C, L03A	0.158	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Neoplasms of unknown behaviour of unspecified site	2F9Z	V04C, L03A	0.405	4	Yes
HRH2	H₂ receptor	Histamine receptors	Aminergic receptors	Class A	Melanoma of skin, unspecified	2C30.Z	V04C, L03A	0.107	3	Yes
HRH2	H₂ receptor	Histamine receptors	Aminergic receptors	Class A	Neoplasms of unknown behaviour of unspecified site	2F9Z	V04C, L03A	0.045	4	Yes
HRH3	H₃ receptor	Histamine receptors	Aminergic receptors	Class A	Melanoma of skin, unspecified	2C30.Z	V04C, L03A	0.087	3	Yes
HRH3	H₃ receptor	Histamine receptors	Aminergic receptors	Class A	Neoplasms of unknown behaviour of unspecified site	2F9Z	V04C, L03A	0.084	4	Yes

Showing 1 to 8 of 8 entries

This ligand is endogenous.