VU0366058
| SMILES | N#Cc1cnc(nc1c1ccc(cc1)F)Nc1nc2c(o1)cccc2 |
| InChIKey | OBFRNKSPNQSVFR-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 6 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 3 |
| Molecular weight (Da) | 331.1 |
Drug properties
| Molecular type | Small molecule |
| Endogenous/Surrogate | Surrogate |
| Approved drug | No |
Database connections
| Ligand site mutations | mGlu5 |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| mGlu5 | GRM5 | Rat | Metabotropic glutamate | C | pKi | 7.08 | 7.08 | 7.08 | Guide to Pharmacology |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| mGlu5 | GRM5 | Rat | Metabotropic glutamate | C | pIC50 | 7.04 | 7.04 | 7.04 | ChEMBL |
| mGlu5 | GRM5 | Rat | Metabotropic glutamate | C | pIC50 | 7.04 | 7.04 | 7.04 | Guide to Pharmacology |