GPCRdb

(-)-adrenaline

SMILES	CNC[C@H](O)c1ccc(O)c(O)c1
InChIKey	UCTWMZQNUQWSLP-VIFPVBQESA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	4
Rotatable bonds	3
Molecular weight (Da)	183.1

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	4LDO 9CBL 8THL 7BTS 9IJE
Ligand site mutations	α_1A α_1B α_2A α_2B β₁ β₂

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	5.10	5.80	6.50	Guide to Pharmacology
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	5.70	5.70	5.70	ChEMBL
α_1A	Q9TSW7	Pig	Adrenoceptors	A	pKi	5.40	5.40	5.40	PDSP Ki database
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	6.59	6.59	6.59	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	3.90	5.20	6.50	Guide to Pharmacology
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	6.19	6.19	6.19	PDSP Ki database
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	5.33	5.33	5.33	PDSP Ki database
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	6.01	6.01	6.01	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.30	6.25	7.20	Guide to Pharmacology
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	6.30	6.30	6.30	Guide to Pharmacology
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	6.26	6.26	6.26	PDSP Ki database
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.66	6.66	6.66	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	3.70	5.55	7.40	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.56	6.68	6.80	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.83	5.83	5.83	PDSP Ki database

Showing 1 to 20 of 61 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	5.60	7.35	9.10	Guide to Pharmacology
α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	6.40	6.40	6.40	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.21	8.21	8.21	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	6.20	6.20	6.20	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pEC50	5.40	7.40	9.40	Guide to Pharmacology
α_1B	ADA1B	Human	Adrenoceptors	A	pEC50	7.12	7.12	7.12	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	5.75	5.75	5.75	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pEC50	6.70	7.20	7.70	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	6.35	6.35	6.35	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	6.77	6.77	6.77	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.50	6.50	6.50	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	7.52	7.88	8.25	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.13	6.13	6.13	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pEC50	6.90	6.90	6.90	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.60	7.60	7.60	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	6.06	6.06	6.06	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	6.70	6.70	6.70	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	7.60	7.60	7.60	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.61	5.61	5.61	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pEC50	7.60	7.60	7.60	Guide to Pharmacology

Showing 1 to 20 of 31 entries

(-)-adrenaline

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Endogenous
Approved drug	Yes

Clinical Trials

Phase I 9

Phase II 18

Phase III 36

Approved Yes

Database connections

Guide To Pharmacology DrugBank Drug Central ChEMBL_compound_ids PubChem GPCRdb
Structure pdb	4LDO 9CBL 8THL 7BTS 9IJE
Ligand site mutations	α_1A α_1B α_2A α_2B β₁ β₂

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute bronchiolitis, unspecified	CA41.Z		0.547	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of other specified type	4A8Y		0.370	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of unspecified type	4A8Z		0.469	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01		0.606	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic rhinitis, unspecified	CA08.0Z		0.561	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Anomalies of pupillary function	LA11.62		0.542	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Asthma	CA23		0.598	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cardiac arrest, unspecified	MC82.Z		0.531	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Chronic rhinosinusitis, unspecified	CA0A.Z		0.599	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cramp or spasm	MB47.3		0.370	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z		0.596	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Gastrointestinal bleeding, unspecified	ME24.9Z		0.434	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Glaucoma, unspecified	9C61.Z		0.541	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Haemorrhage, not elsewhere classified	MG27		0.557	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Heart failure, unspecified	BD1Z		0.593	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Hypoglycaemia without associated diabetes	5A41		0.079	1	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Hypotension, unspecified	BA2Z		0.603	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Idiopathic angioedema	EB04		0.370	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nasal congestion	MD11.9		0.607	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Other allergic rhinitis	CA08.03		0.259	4	Yes

Showing 1 to 20 of 234 entries

…

This ligand is endogenous.

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(-)-adrenaline

(-)-adrenaline

Chemical Properties

Database connections

Bioactivities

(-)-adrenaline

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information