Structure information

α1A-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8THL

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-40524-2

PUBLICATION DATE

Aug. 16, 2023

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(-)-adrenaline D106 3.32x32 TM3 polar (charge-assisted hydrogen bond)
(-)-adrenaline V107 3.33x33 TM3 hydrophobic
(-)-adrenaline V107 3.33x33 TM3 Van der Waals
(-)-adrenaline C110 3.36x36 TM3 polar (hydrogen bond)
(-)-adrenaline S188 5.42x43 TM5 polar (hydrogen bond)
(-)-adrenaline S188 5.42x43 TM5 Van der Waals
(-)-adrenaline A189 5.43x44 TM5 Van der Waals
(-)-adrenaline W285 6.48x48 TM6 Van der Waals
(-)-adrenaline W285 6.48x48 TM6 hydrophobic
(-)-adrenaline F288 6.51x51 TM6 aromatic (edge-to-face)
(-)-adrenaline F288 6.51x51 TM6 Van der Waals
(-)-adrenaline F289 6.52x52 TM6 Van der Waals
(-)-adrenaline F289 6.52x52 TM6 hydrophobic
(-)-adrenaline M292 6.55x55 TM6 Van der Waals
(-)-adrenaline F312 7.39x38 TM7 hydrophobic
(-)-adrenaline F312 7.39x38 TM7 Van der Waals
(-)-adrenaline Y316 7.43x42 TM7 hydrophobic
(-)-adrenaline Y316 7.43x42 TM7 Van der Waals

Ligands

(-)-adrenaline

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

I N G L V G F L I L G G L I V G L L I A 1 V N L A V A D L L L T T S V L P F S A I F 2 I C L G M I S A T C C L V D V A A W I N 3 G L M A L L C V W A L S L V I S I G P L 4 Y M V L I I A L P L Y F S G L A S F L V Y 5 G I V V G C F V L C W L P F F L V M P I 6 I P N I C S N L Y G L W F V I K F V T 7
Download: PNG | SVG
ICL1 R H L H ICL1ECL1 Y W A F ECL1ICL2 P L R Y P T I V ICL2ECL2 R Q P A P E D E T I C Q I N E ECL2ICL3 K T D K S D S E Q V T L R I H R K N A P A G G S G M A S A K T K T H F S V R ICL3ECL3 P D F K P ECL3N-term M V F L S G N A S D S S N C T Q P P A N-termC-term I Q C L C R K Q S S K H A L G Y T L H P P S Q A V E G Q H K D M V R I P V G S R E T F Y R I S K T D G V C E W K F F S S M P R G S A R I T V S K D Q S S C T T A R V R S K S F L Q V C C C V G P S T P S L D K N H Q V P T I K V H T I S L S E N G E E V C-term P V N I S K A I L L G V I L G G L I L F G V L G N I L V I L S V A C H S V T H Y Y I V N L A V A D L L L T S T V L P F S A I F E V L G G R V F C N I W A A V D V L C C T A S I M G L C I I S I D R Y I G V S Y T Q R R G L M A L L C V W A L S L V I S I G P L F G W E P G Y V L F S A L G S F Y L P L A I I L V M Y C R V Y V V A K R E S R G L K S G L L L K F S R E K K A A K T L G I V V G C F V L C W L P F F L V M P I G S F F S E T V F K I V F W L G Y L N S C I N P I I Y P C S S Q E F Q N F K K A V L R
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(A)
α1A-adrenoceptor
TM3
3x32 3.32x32 D106
3x33 3.33x33 V107
3x36 3.36x36 C110
TM5
5x43 5.42x43 S188
5x44 5.43x44 A189
TM6
6x48 6.48x48 W285
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 M292
TM7
7x38 7.39x38 F312
7x42 7.43x42 Y316